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Declining Antibody Affinity Over Time After Human Vaccination With a Plasmodium falciparum Merozoite Vaccine Candidate

Persson, Kristina E M LU ; Horton, Jessica L ; Kurtovic, Liriye ; McCarthy, James S ; Anders, Robin F and Beeson, James G (2024) In The Journal of infectious diseases 230(3). p.753-757
Abstract

UNLABELLED: Maintaining high-affinity antibodies after vaccination may be important for long-lasting immunity to malaria, but data on induction and kinetics of affinity is lacking. In a phase 1 malaria vaccine trial, antibody affinity increased following a second vaccination but declined substantially over 12 months, suggesting poor maintenance of high-affinity antibodies.

CLINICAL TRIALS REGISTRATION: Australian New Zealand Clinical Trials Registry ACTRN12607000552482.

Please use this url to cite or link to this publication:
author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Humans, Malaria Vaccines/immunology, Plasmodium falciparum/immunology, Malaria, Falciparum/prevention & control, Antibodies, Protozoan/immunology, Antibody Affinity, Merozoites/immunology, Adult, Vaccination, Male, Female, Young Adult, Australia, Adolescent
in
The Journal of infectious diseases
volume
230
issue
3
pages
753 - 757
publisher
Oxford University Press
external identifiers
  • pmid:38723177
  • scopus:85204920702
ISSN
1537-6613
DOI
10.1093/infdis/jiae259
language
English
LU publication?
yes
additional info
© The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America.
id
f78856ee-4325-467b-84f9-052808205726
date added to LUP
2024-10-17 16:36:11
date last changed
2025-07-12 03:31:59
@article{f78856ee-4325-467b-84f9-052808205726,
  abstract     = {{<p>UNLABELLED: Maintaining high-affinity antibodies after vaccination may be important for long-lasting immunity to malaria, but data on induction and kinetics of affinity is lacking. In a phase 1 malaria vaccine trial, antibody affinity increased following a second vaccination but declined substantially over 12 months, suggesting poor maintenance of high-affinity antibodies.</p><p>CLINICAL TRIALS REGISTRATION: Australian New Zealand Clinical Trials Registry ACTRN12607000552482.</p>}},
  author       = {{Persson, Kristina E M and Horton, Jessica L and Kurtovic, Liriye and McCarthy, James S and Anders, Robin F and Beeson, James G}},
  issn         = {{1537-6613}},
  keywords     = {{Humans; Malaria Vaccines/immunology; Plasmodium falciparum/immunology; Malaria, Falciparum/prevention & control; Antibodies, Protozoan/immunology; Antibody Affinity; Merozoites/immunology; Adult; Vaccination; Male; Female; Young Adult; Australia; Adolescent}},
  language     = {{eng}},
  month        = {{09}},
  number       = {{3}},
  pages        = {{753--757}},
  publisher    = {{Oxford University Press}},
  series       = {{The Journal of infectious diseases}},
  title        = {{Declining Antibody Affinity Over Time After Human Vaccination With a Plasmodium falciparum Merozoite Vaccine Candidate}},
  url          = {{http://dx.doi.org/10.1093/infdis/jiae259}},
  doi          = {{10.1093/infdis/jiae259}},
  volume       = {{230}},
  year         = {{2024}},
}