Deranged Wnt signaling is frequent in hereditary nonpolyposis colorectal cancer.
Isinger Ekstrand, Anna LU
; Therkildsen, Christina
LU
; Bernstein, Inge
and Nilbert, Mef
LU
(2011)
In Familial Cancer
10.
p.239-243
- Abstract
- The Wnt signaling pathway is frequently deranged in colorectal cancer and is a key target for future preventive and therapeutic approaches. Colorectal cancers associated with the hereditary nonpolyposis colorectal cancer (HNPCC) syndrome are characterized by wide-spread microsatellite instability, but show few gross genomic alterations. We characterized expression of the Wnt signaling pathway markers β-catenin, E-cadherin, TCF-4, and PTEN using immunohistochemical staining in colorectal cancers from individuals with HNPCC. Reduced membranous staining for β-catenin was found in 64% and for E-cadherin in 80% with strong correlation between these markers (P = 0.001). Nuclear β-catenin staining was detected in 19% of the tumors. Overexpression... (More)
- The Wnt signaling pathway is frequently deranged in colorectal cancer and is a key target for future preventive and therapeutic approaches. Colorectal cancers associated with the hereditary nonpolyposis colorectal cancer (HNPCC) syndrome are characterized by wide-spread microsatellite instability, but show few gross genomic alterations. We characterized expression of the Wnt signaling pathway markers β-catenin, E-cadherin, TCF-4, and PTEN using immunohistochemical staining in colorectal cancers from individuals with HNPCC. Reduced membranous staining for β-catenin was found in 64% and for E-cadherin in 80% with strong correlation between these markers (P = 0.001). Nuclear β-catenin staining was detected in 19% of the tumors. Overexpression of TCF-4, which is activated by β-catenin, was found in 89% and downregulation of PTEN, which suppresses nuclear accumulation of β-catenin, was present in 54% of the tumors. In summary, altered expression of target molecules in the Wnt signaling pathway was demonstrated in the vast majority of the HNPCC-associated tumors, which support deranged Wnt-signaling as a central tumorigenic mechanism also in MMR defective colorectal cancer. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1756721
- author
- Isinger Ekstrand, Anna
LU
; Therkildsen, Christina
LU
; Bernstein, Inge
and Nilbert, Mef
LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Familial Cancer
- volume
- 10
- pages
- 239 - 243
- publisher
- Springer
- external identifiers
-
- wos:000290937500009
- pmid:21132538
- scopus:79958140999
- ISSN
- 1389-9600
- DOI
- 10.1007/s10689-010-9406-x
- language
- English
- LU publication?
- yes
- id
- f7add768-faa0-42a1-8554-94d3c72c4cd7 (old id 1756721)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21132538?dopt=Abstract
- date added to LUP
- 2016-04-04 08:33:53
- date last changed
- 2022-01-29 03:37:35
@article{f7add768-faa0-42a1-8554-94d3c72c4cd7,
abstract = {{The Wnt signaling pathway is frequently deranged in colorectal cancer and is a key target for future preventive and therapeutic approaches. Colorectal cancers associated with the hereditary nonpolyposis colorectal cancer (HNPCC) syndrome are characterized by wide-spread microsatellite instability, but show few gross genomic alterations. We characterized expression of the Wnt signaling pathway markers β-catenin, E-cadherin, TCF-4, and PTEN using immunohistochemical staining in colorectal cancers from individuals with HNPCC. Reduced membranous staining for β-catenin was found in 64% and for E-cadherin in 80% with strong correlation between these markers (P = 0.001). Nuclear β-catenin staining was detected in 19% of the tumors. Overexpression of TCF-4, which is activated by β-catenin, was found in 89% and downregulation of PTEN, which suppresses nuclear accumulation of β-catenin, was present in 54% of the tumors. In summary, altered expression of target molecules in the Wnt signaling pathway was demonstrated in the vast majority of the HNPCC-associated tumors, which support deranged Wnt-signaling as a central tumorigenic mechanism also in MMR defective colorectal cancer.}},
author = {{Isinger Ekstrand, Anna and Therkildsen, Christina and Bernstein, Inge and Nilbert, Mef}},
issn = {{1389-9600}},
language = {{eng}},
pages = {{239--243}},
publisher = {{Springer}},
series = {{Familial Cancer}},
title = {{Deranged Wnt signaling is frequent in hereditary nonpolyposis colorectal cancer.}},
url = {{http://dx.doi.org/10.1007/s10689-010-9406-x}},
doi = {{10.1007/s10689-010-9406-x}},
volume = {{10}},
year = {{2011}},
}