Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Glycodendrimers as Potential Multitalented Therapeutics in Alzheimer’s Disease

Klementieva, Oxana LU orcid (2019) p.1-16
Abstract
Finding successful therapies for the treatment of Alzheimer’s disease (AD) is one of the most challenging tasks existing for human health. Several drugs have been found and validated in preclinical studies with some success, but not with the desired breakthroughs in the following clinical development phases. AD causes multiple brain dysfunctions that can be described as a brain organ failure, resulting in significant cognitive decline. Aggregation of amyloid proteins and neuronal loss are the hallmarks of AD. Thus, one of the strategies to treat AD is to find a multifunctional drug that may combine both anti-aggregation and neuroprotective properties. Such a candidate could be chemically modified dendrimers. Dendrimers are branched,... (More)
Finding successful therapies for the treatment of Alzheimer’s disease (AD) is one of the most challenging tasks existing for human health. Several drugs have been found and validated in preclinical studies with some success, but not with the desired breakthroughs in the following clinical development phases. AD causes multiple brain dysfunctions that can be described as a brain organ failure, resulting in significant cognitive decline. Aggregation of amyloid proteins and neuronal loss are the hallmarks of AD. Thus, one of the strategies to treat AD is to find a multifunctional drug that may combine both anti-aggregation and neuroprotective properties. Such a candidate could be chemically modified dendrimers. Dendrimers are branched, nonlinear molecules with multiple reactive groups located on their surface. Chemical modification of reactive surface groups defines the property of the dendrimers. In this chapter, I will discuss poly(propylene imine) dendrimers with the surface functionalized with histidine and maltose as an example of a multifunctional therapeutic drug candidate able to protect the memory of AD transgenic model mice. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
dendrimer, histidine, aggregation, synapse, memory, Alzheimer’s disease
host publication
Neuroprotection : New Approaches and Prospects - New Approaches and Prospects
editor
Otero-Losada, Matilde ; Capani, Francisco and Perez Lloret, Santiago
pages
16 pages
publisher
IntechOpen
ISBN
978-1-83969-261-1
DOI
10.5772/intechopen.88974
language
English
LU publication?
yes
additional info
Copyright year: 2020
id
f7d5b4b0-7537-44a8-b474-76707655888d
date added to LUP
2019-09-13 15:13:31
date last changed
2023-08-07 14:43:52
@inbook{f7d5b4b0-7537-44a8-b474-76707655888d,
  abstract     = {{Finding successful therapies for the treatment of Alzheimer’s disease (AD) is one of the most challenging tasks existing for human health. Several drugs have been found and validated in preclinical studies with some success, but not with the desired breakthroughs in the following clinical development phases. AD causes multiple brain dysfunctions that can be described as a brain organ failure, resulting in significant cognitive decline. Aggregation of amyloid proteins and neuronal loss are the hallmarks of AD. Thus, one of the strategies to treat AD is to find a multifunctional drug that may combine both anti-aggregation and neuroprotective properties. Such a candidate could be chemically modified dendrimers. Dendrimers are branched, nonlinear molecules with multiple reactive groups located on their surface. Chemical modification of reactive surface groups defines the property of the dendrimers. In this chapter, I will discuss poly(propylene imine) dendrimers with the surface functionalized with histidine and maltose as an example of a multifunctional therapeutic drug candidate able to protect the memory of AD transgenic model mice.}},
  author       = {{Klementieva, Oxana}},
  booktitle    = {{Neuroprotection : New Approaches and Prospects}},
  editor       = {{Otero-Losada, Matilde and Capani, Francisco and Perez Lloret, Santiago}},
  isbn         = {{978-1-83969-261-1}},
  keywords     = {{dendrimer, histidine, aggregation, synapse, memory, Alzheimer’s disease}},
  language     = {{eng}},
  month        = {{09}},
  pages        = {{1--16}},
  publisher    = {{IntechOpen}},
  title        = {{Glycodendrimers as Potential Multitalented Therapeutics in Alzheimer’s Disease}},
  url          = {{http://dx.doi.org/10.5772/intechopen.88974}},
  doi          = {{10.5772/intechopen.88974}},
  year         = {{2019}},
}