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Methods and statistics for diffusion MRI tractometry

Chamberland, Maxime ; St-Jean, Samuel LU orcid ; Jones, Derek K. ; Descoteaux, Maxime and Leemans, Alexander (2025) p.439-450
Abstract

Analyzing microstructural properties projected along white matter pathways derived from diffusion magnetic resonance imaging (MRI) has become increasingly popular in recent years. Along-streamline profiling based on diffusion MRI tractometry is a framework that maps summary measures of the diffusion data (e.g., fractional anisotropy) at multiple points along a given pathway, resulting in a so-called bundle-profile. In this chapter, we introduce the various steps involved in along-streamline profiling, covering concepts related to bundle segmentation, core streamline definition, and statistical analysis of bundle-profiles. Our aim is to provide a general overview of the tractometry framework and to encourage its application.

Please use this url to cite or link to this publication:
author
; ; ; and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Along-streamline profiling, Diffusion MRI, Tractography, Tractometry
host publication
Handbook of Diffusion MR Tractography : Imaging Methods, Biophysical Models, Algorithms and Applications - Imaging Methods, Biophysical Models, Algorithms and Applications
pages
12 pages
publisher
Elsevier
external identifiers
  • scopus:85218392552
ISBN
9780128188941
9780128188958
DOI
10.1016/B978-0-12-818894-1.00023-9
language
English
LU publication?
yes
id
f7ddc3e3-beb2-4fc2-ae90-91d35da40f36
date added to LUP
2025-06-05 10:57:05
date last changed
2025-10-23 23:47:38
@inbook{f7ddc3e3-beb2-4fc2-ae90-91d35da40f36,
  abstract     = {{<p>Analyzing microstructural properties projected along white matter pathways derived from diffusion magnetic resonance imaging (MRI) has become increasingly popular in recent years. Along-streamline profiling based on diffusion MRI tractometry is a framework that maps summary measures of the diffusion data (e.g., fractional anisotropy) at multiple points along a given pathway, resulting in a so-called bundle-profile. In this chapter, we introduce the various steps involved in along-streamline profiling, covering concepts related to bundle segmentation, core streamline definition, and statistical analysis of bundle-profiles. Our aim is to provide a general overview of the tractometry framework and to encourage its application.</p>}},
  author       = {{Chamberland, Maxime and St-Jean, Samuel and Jones, Derek K. and Descoteaux, Maxime and Leemans, Alexander}},
  booktitle    = {{Handbook of Diffusion MR Tractography : Imaging Methods, Biophysical Models, Algorithms and Applications}},
  isbn         = {{9780128188941}},
  keywords     = {{Along-streamline profiling; Diffusion MRI; Tractography; Tractometry}},
  language     = {{eng}},
  pages        = {{439--450}},
  publisher    = {{Elsevier}},
  title        = {{Methods and statistics for diffusion MRI tractometry}},
  url          = {{http://dx.doi.org/10.1016/B978-0-12-818894-1.00023-9}},
  doi          = {{10.1016/B978-0-12-818894-1.00023-9}},
  year         = {{2025}},
}