S100 protein, an early and prognostic serum marker for brain damage following cardiac surgery
(1996) In Scandinavian Journal of Thoracic and Cardiovascular Surgery 30(Suppl 44). p.72-72- Abstract
S100 protein is a marker for brain damage easily analysed in blood. The serum level immediatly after termination of extracorporeal circulation (ECC) is increased and associated to age and the duration of perfusion. A prolonged residual concentration indicates cellular brain damage. The objective of this study was to ascertain if the prognosis of individual patients, with stroke following ECC, could be predicted by the S100 levels. 224 patients with an uneventful outcome constituted a reference population. Blood samples for the analysis of S100 were collected at termination of ECC (TO) and at 5, 15 and 48 hours thereafter. Eight patients with stroke following ECC were analysed. In 4, S100 levels continued to increase after ECC. The... (More)
S100 protein is a marker for brain damage easily analysed in blood. The serum level immediatly after termination of extracorporeal circulation (ECC) is increased and associated to age and the duration of perfusion. A prolonged residual concentration indicates cellular brain damage. The objective of this study was to ascertain if the prognosis of individual patients, with stroke following ECC, could be predicted by the S100 levels. 224 patients with an uneventful outcome constituted a reference population. Blood samples for the analysis of S100 were collected at termination of ECC (TO) and at 5, 15 and 48 hours thereafter. Eight patients with stroke following ECC were analysed. In 4, S100 levels continued to increase after ECC. The volume of brain infarctions were large and in 3 of the patients outcome was fatal. In 4 other patients with small volume brain injury S100 dropped initially, but after 5 hours the elimination slowed down, indicating a small but persistant release. In 3 of these patients recovery was complete or with minor residuals. The fourth patient never regained consciousness and died. The levels from serial S100 measurements early after cardiac surgery were related to the size of brain injury and a prognostic value is therefore suggested.
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- author
- Blomqvist, S ; Westaby, S ; Alling, Christer LU ; Johnsson, Per and Jönsson, Henrik LU
- publishing date
- 1996
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Scandinavian Journal of Thoracic and Cardiovascular Surgery
- volume
- 30
- issue
- Suppl 44
- pages
- 1 pages
- publisher
- Taylor & Francis
- external identifiers
-
- scopus:33747698437
- ISSN
- 0036-5580
- language
- English
- LU publication?
- no
- id
- f801030f-b1c8-4f04-9f4e-0159e0e77eab
- date added to LUP
- 2017-08-23 14:37:33
- date last changed
- 2022-01-30 22:14:53
@article{f801030f-b1c8-4f04-9f4e-0159e0e77eab,
abstract = {{<p>S100 protein is a marker for brain damage easily analysed in blood. The serum level immediatly after termination of extracorporeal circulation (ECC) is increased and associated to age and the duration of perfusion. A prolonged residual concentration indicates cellular brain damage. The objective of this study was to ascertain if the prognosis of individual patients, with stroke following ECC, could be predicted by the S100 levels. 224 patients with an uneventful outcome constituted a reference population. Blood samples for the analysis of S100 were collected at termination of ECC (TO) and at 5, 15 and 48 hours thereafter. Eight patients with stroke following ECC were analysed. In 4, S100 levels continued to increase after ECC. The volume of brain infarctions were large and in 3 of the patients outcome was fatal. In 4 other patients with small volume brain injury S100 dropped initially, but after 5 hours the elimination slowed down, indicating a small but persistant release. In 3 of these patients recovery was complete or with minor residuals. The fourth patient never regained consciousness and died. The levels from serial S100 measurements early after cardiac surgery were related to the size of brain injury and a prognostic value is therefore suggested.</p>}},
author = {{Blomqvist, S and Westaby, S and Alling, Christer and Johnsson, Per and Jönsson, Henrik}},
issn = {{0036-5580}},
language = {{eng}},
number = {{Suppl 44}},
pages = {{72--72}},
publisher = {{Taylor & Francis}},
series = {{Scandinavian Journal of Thoracic and Cardiovascular Surgery}},
title = {{S100 protein, an early and prognostic serum marker for brain damage following cardiac surgery}},
volume = {{30}},
year = {{1996}},
}