Bronchodilator response of advanced lung function parameters depending on COPD severity
(2016) In International Journal of COPD 11(1). p.2939-2950- Abstract
Background: COPD is defined as partly irreversible airflow obstruction. The response pattern of bronchodilators has not been followed in advanced lung function parameters. Purpose: The aim of this study was to investigate bronchodilator response pattern in advanced lung function parameters in a continuous fashion along forced expiratory volume in 1 second (FEV1) percent predicted (%p) in COPD patients and controls. Patients and methods: Eighty-one smokers/ex-smokers (41 controls and 40 COPD) performed spirometry, body plethysmography, impulse oscillometry and single-breath helium dilution carbon monoxide diffusion at baseline, after salbutamol inhalation and then after an additional inhalation of ipratropium. Results: Most... (More)
Background: COPD is defined as partly irreversible airflow obstruction. The response pattern of bronchodilators has not been followed in advanced lung function parameters. Purpose: The aim of this study was to investigate bronchodilator response pattern in advanced lung function parameters in a continuous fashion along forced expiratory volume in 1 second (FEV1) percent predicted (%p) in COPD patients and controls. Patients and methods: Eighty-one smokers/ex-smokers (41 controls and 40 COPD) performed spirometry, body plethysmography, impulse oscillometry and single-breath helium dilution carbon monoxide diffusion at baseline, after salbutamol inhalation and then after an additional inhalation of ipratropium. Results: Most pulmonary function parameters showed a linear increase in response to decreased FEV1%p. The subjects were divided into groups of FEV1%p<65 and >65, and the findings from continuous analysis were verified. The exceptions to this linear response were inspiratory capacity (IC), forced vital capacity (FVC), FEV1/FVC and expiratory resistance (Rex), which showed a segmented response relationship to FEV1%p. IC and FVC, with break points (BP) of 57 and 58 FEV1%p respectively, showed no response above, but an incresed slope below the BP. In addition, in patients with FEV1%p<65 and >65, response of FEV1%p did not correlate to response of volume parameters. Conclusion: Response of several advanced lung function parameters differs depending on patients’ baseline FEV1%p, and specifically response of volume parameters is most pronounced in COPD patients with FEV1%p<65. Volume and resistance responses do not follow the flow response measured with FEV1 and may thus be used as a complement to FEV1 reversibility to identify flow, volume and resistance responders.
(Less)
- author
- Jarenbäck, Linnea LU ; Eriksson, Göran LU ; Peterson, Stefan ; Ankerst, Jaro LU ; Bjermer, Leif LU and Tufvesson, Ellen LU
- organization
- publishing date
- 2016-11-25
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Body plethysmography, Bronchodilation, COPD, IOS, Lung function, Reversibility
- in
- International Journal of COPD
- volume
- 11
- issue
- 1
- pages
- 12 pages
- publisher
- Dove Medical Press Ltd.
- external identifiers
-
- scopus:85000366435
- pmid:27932874
- wos:000388480200002
- ISSN
- 1176-9106
- DOI
- 10.2147/COPD.S111573
- language
- English
- LU publication?
- yes
- id
- f833f528-e8ad-431c-a6cd-23fec15bf595
- date added to LUP
- 2016-12-19 09:39:28
- date last changed
- 2024-08-24 03:30:55
@article{f833f528-e8ad-431c-a6cd-23fec15bf595, abstract = {{<p>Background: COPD is defined as partly irreversible airflow obstruction. The response pattern of bronchodilators has not been followed in advanced lung function parameters. Purpose: The aim of this study was to investigate bronchodilator response pattern in advanced lung function parameters in a continuous fashion along forced expiratory volume in 1 second (FEV<sub>1</sub>) percent predicted (%p) in COPD patients and controls. Patients and methods: Eighty-one smokers/ex-smokers (41 controls and 40 COPD) performed spirometry, body plethysmography, impulse oscillometry and single-breath helium dilution carbon monoxide diffusion at baseline, after salbutamol inhalation and then after an additional inhalation of ipratropium. Results: Most pulmonary function parameters showed a linear increase in response to decreased FEV<sub>1</sub>%p. The subjects were divided into groups of FEV<sub>1</sub>%p<65 and >65, and the findings from continuous analysis were verified. The exceptions to this linear response were inspiratory capacity (IC), forced vital capacity (FVC), FEV<sub>1</sub>/FVC and expiratory resistance (R<sub>ex</sub>), which showed a segmented response relationship to FEV<sub>1</sub>%p. IC and FVC, with break points (BP) of 57 and 58 FEV<sub>1</sub>%p respectively, showed no response above, but an incresed slope below the BP. In addition, in patients with FEV<sub>1</sub>%p<65 and >65, response of FEV<sub>1</sub>%p did not correlate to response of volume parameters. Conclusion: Response of several advanced lung function parameters differs depending on patients’ baseline FEV<sub>1</sub>%p, and specifically response of volume parameters is most pronounced in COPD patients with FEV<sub>1</sub>%p<65. Volume and resistance responses do not follow the flow response measured with FEV<sub>1</sub> and may thus be used as a complement to FEV<sub>1</sub> reversibility to identify flow, volume and resistance responders.</p>}}, author = {{Jarenbäck, Linnea and Eriksson, Göran and Peterson, Stefan and Ankerst, Jaro and Bjermer, Leif and Tufvesson, Ellen}}, issn = {{1176-9106}}, keywords = {{Body plethysmography; Bronchodilation; COPD; IOS; Lung function; Reversibility}}, language = {{eng}}, month = {{11}}, number = {{1}}, pages = {{2939--2950}}, publisher = {{Dove Medical Press Ltd.}}, series = {{International Journal of COPD}}, title = {{Bronchodilator response of advanced lung function parameters depending on COPD severity}}, url = {{http://dx.doi.org/10.2147/COPD.S111573}}, doi = {{10.2147/COPD.S111573}}, volume = {{11}}, year = {{2016}}, }