Predictors of telomere content in dragon lizards
(2012) In Naturwissenschaften 99(8). p.661-664- Abstract
- Telomeres shorten as a consequence of DNA
replication, in particular in cells with low production of
telomerase and perhaps in response to physiological stress
from exposure to reactive oxygen species, such as superoxide.
This process of telomere attrition is countered by innate
antioxidation, such as via the production of superoxide
dismutase. We studied the inheritance of telomere length
in the Australian painted dragon lizard (Ctenophorus pictus)
and the extent to which telomere length covaries with masscorrected
maternal reproductive investment, which reflects
the level of circulating yolk precursor and antioxidant,
vitellogenin. Our... (More) - Telomeres shorten as a consequence of DNA
replication, in particular in cells with low production of
telomerase and perhaps in response to physiological stress
from exposure to reactive oxygen species, such as superoxide.
This process of telomere attrition is countered by innate
antioxidation, such as via the production of superoxide
dismutase. We studied the inheritance of telomere length
in the Australian painted dragon lizard (Ctenophorus pictus)
and the extent to which telomere length covaries with masscorrected
maternal reproductive investment, which reflects
the level of circulating yolk precursor and antioxidant,
vitellogenin. Our predictors of offspring telomere length
explained 72 % of telomere variation (including interstitial
telomeres if such are present). Maternal telomere length and
reproductive investment were positively influencing offspring
telomere length in our analyses, whereas flow
cytometry-estimated superoxide level was negatively
impacting offspring telomere length. We suggest that the
effects of superoxide on hatchling telomere shortening may
be partly balanced by transgenerational effects of vitellogenin
antioxidation. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3050486
- author
- Ballen, Cissy ; Healey, Mo ; Wilson, Mark ; Tobler, Michael LU and Olsson, Mats
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Lizard, Reactive oxygen species, Superoxide, Telomere, Vitellogenin
- in
- Naturwissenschaften
- volume
- 99
- issue
- 8
- pages
- 661 - 664
- publisher
- Springer
- external identifiers
-
- wos:000307245100008
- scopus:84866256294
- pmid:22772478
- ISSN
- 1432-1904
- DOI
- 10.1007/s00114-012-0941-1
- language
- English
- LU publication?
- yes
- id
- f86948bd-7656-4c8a-a338-8ffc0b1b931a (old id 3050486)
- date added to LUP
- 2016-04-01 11:07:28
- date last changed
- 2024-01-07 08:56:06
@article{f86948bd-7656-4c8a-a338-8ffc0b1b931a,
abstract = {{Telomeres shorten as a consequence of DNA<br/><br>
replication, in particular in cells with low production of<br/><br>
telomerase and perhaps in response to physiological stress<br/><br>
from exposure to reactive oxygen species, such as superoxide.<br/><br>
This process of telomere attrition is countered by innate<br/><br>
antioxidation, such as via the production of superoxide<br/><br>
dismutase. We studied the inheritance of telomere length<br/><br>
in the Australian painted dragon lizard (Ctenophorus pictus)<br/><br>
and the extent to which telomere length covaries with masscorrected<br/><br>
maternal reproductive investment, which reflects<br/><br>
the level of circulating yolk precursor and antioxidant,<br/><br>
vitellogenin. Our predictors of offspring telomere length<br/><br>
explained 72 % of telomere variation (including interstitial<br/><br>
telomeres if such are present). Maternal telomere length and<br/><br>
reproductive investment were positively influencing offspring<br/><br>
telomere length in our analyses, whereas flow<br/><br>
cytometry-estimated superoxide level was negatively<br/><br>
impacting offspring telomere length. We suggest that the<br/><br>
effects of superoxide on hatchling telomere shortening may<br/><br>
be partly balanced by transgenerational effects of vitellogenin<br/><br>
antioxidation.}},
author = {{Ballen, Cissy and Healey, Mo and Wilson, Mark and Tobler, Michael and Olsson, Mats}},
issn = {{1432-1904}},
keywords = {{Lizard; Reactive oxygen species; Superoxide; Telomere; Vitellogenin}},
language = {{eng}},
number = {{8}},
pages = {{661--664}},
publisher = {{Springer}},
series = {{Naturwissenschaften}},
title = {{Predictors of telomere content in dragon lizards}},
url = {{http://dx.doi.org/10.1007/s00114-012-0941-1}},
doi = {{10.1007/s00114-012-0941-1}},
volume = {{99}},
year = {{2012}},
}