Autoimmunity in insulin-dependent diabetes mellitus
Nerup, Jørn LU and Lernmark, Ake LU
(1981)
In The American journal of medicine
70(1).
p.135-141
- Abstract
Genetic susceptibility, environmental factors and immune mechanisms are implicated in the pathogenesis and etiology of insulindependent diabetes mellitus. The onset of the disease is associated with a major loss of beta cells, and inflammatory cells may be seen in and around the islets of Langerhans. Insulin-dependent diabetes is often associated with autoimmune endocrinopathies. Antipancreatic cell-mediated autoimmunity is found predominantly in young patients with insulin-dependent diabetes of recent onset as are antibodies reactive with cytoplasmic components or cell surface determinants of islet cells. Antibodies reactive with live islet cells may mediate complement-dependent cytotoxicity. The antigen(s) in the islet cells remain(s)... (More)
Genetic susceptibility, environmental factors and immune mechanisms are implicated in the pathogenesis and etiology of insulindependent diabetes mellitus. The onset of the disease is associated with a major loss of beta cells, and inflammatory cells may be seen in and around the islets of Langerhans. Insulin-dependent diabetes is often associated with autoimmune endocrinopathies. Antipancreatic cell-mediated autoimmunity is found predominantly in young patients with insulin-dependent diabetes of recent onset as are antibodies reactive with cytoplasmic components or cell surface determinants of islet cells. Antibodies reactive with live islet cells may mediate complement-dependent cytotoxicity. The antigen(s) in the islet cells remain(s) to be identified and characterized. Further studies will be necessary to determine whether autoimmunity is the cause of beta-cell destruction or whether it is a consequence of damages caused by exogenous agents in susceptible persons.
(Less)
- author
- Nerup, Jørn
LU
and Lernmark, Ake
LU
- publishing date
- 1981-01-01
- type
- Contribution to journal
- publication status
- published
- in
- The American journal of medicine
- volume
- 70
- issue
- 1
- pages
- 135 - 141
- publisher
- Elsevier
- external identifiers
-
- scopus:0019400456
- pmid:7006386
- ISSN
- 0002-9343
- DOI
- 10.1016/0002-9343(81)90420-4
- language
- English
- LU publication?
- no
- id
- f86b9dec-6b26-4c7d-94c8-b567e7d399bd
- date added to LUP
- 2019-09-16 15:36:32
- date last changed
- 2024-03-13 08:12:18
@article{f86b9dec-6b26-4c7d-94c8-b567e7d399bd,
abstract = {{<p>Genetic susceptibility, environmental factors and immune mechanisms are implicated in the pathogenesis and etiology of insulindependent diabetes mellitus. The onset of the disease is associated with a major loss of beta cells, and inflammatory cells may be seen in and around the islets of Langerhans. Insulin-dependent diabetes is often associated with autoimmune endocrinopathies. Antipancreatic cell-mediated autoimmunity is found predominantly in young patients with insulin-dependent diabetes of recent onset as are antibodies reactive with cytoplasmic components or cell surface determinants of islet cells. Antibodies reactive with live islet cells may mediate complement-dependent cytotoxicity. The antigen(s) in the islet cells remain(s) to be identified and characterized. Further studies will be necessary to determine whether autoimmunity is the cause of beta-cell destruction or whether it is a consequence of damages caused by exogenous agents in susceptible persons.</p>}},
author = {{Nerup, Jørn and Lernmark, Ake}},
issn = {{0002-9343}},
language = {{eng}},
month = {{01}},
number = {{1}},
pages = {{135--141}},
publisher = {{Elsevier}},
series = {{The American journal of medicine}},
title = {{Autoimmunity in insulin-dependent diabetes mellitus}},
url = {{http://dx.doi.org/10.1016/0002-9343(81)90420-4}},
doi = {{10.1016/0002-9343(81)90420-4}},
volume = {{70}},
year = {{1981}},
}