Advanced

Coeliac disease and invasive pneumococcal disease : a population-based cohort study

Röckert Tjernberg, A; Bonnedahl, J; Inghammar, M LU ; Egesten, A LU ; Kahlmeter, G.; Nauclér, P; Henriques-Normark, B. and Ludvigsson, Jonas F. (2017) In Epidemiology and Infection 145(6). p.1203-1209
Abstract

Severe infections are recognized complications of coeliac disease (CD). In the present study we aimed to examine whether individuals with CD are at increased risk of invasive pneumococcal disease (IPD). To do so, we performed a population-based cohort study including 29 012 individuals with biopsy-proven CD identified through biopsy reports from all pathology departments in Sweden. Each individual with CD was matched with up to five controls (n = 144 257). IPD events were identified through regional and national microbiological databases, including the National Surveillance System for Infectious Diseases. We used Cox regression analyses to estimate hazard ratios (HRs) for diagnosed IPD. A total of 207 individuals had a record of IPD... (More)

Severe infections are recognized complications of coeliac disease (CD). In the present study we aimed to examine whether individuals with CD are at increased risk of invasive pneumococcal disease (IPD). To do so, we performed a population-based cohort study including 29 012 individuals with biopsy-proven CD identified through biopsy reports from all pathology departments in Sweden. Each individual with CD was matched with up to five controls (n = 144 257). IPD events were identified through regional and national microbiological databases, including the National Surveillance System for Infectious Diseases. We used Cox regression analyses to estimate hazard ratios (HRs) for diagnosed IPD. A total of 207 individuals had a record of IPD whereas 45/29 012 had CD (0·15%) and 162/144 257 were controls (0·11%). This corresponded to a 46% increased risk for IPD [HR 1·46, 95% confidence interval (CI) 1·05-2·03]. The risk estimate was similar after adjustment for socioeconomic status, educational level and comorbidities, but then failed to attain statistical significance (adjusted HR 1·40, 95% CI 0·99-1·97). Nonetheless, our study shows a trend towards an increased risk for IPD in CD patients. The findings support results seen in earlier research and taking that into consideration individuals with CD may be considered for pneumococcal vaccination.

(Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Epidemiology and Infection
volume
145
issue
6
pages
7 pages
publisher
Cambridge University Press
external identifiers
  • scopus:85010858898
  • wos:000398972000012
ISSN
0950-2688
DOI
10.1017/S0950268816003204
language
English
LU publication?
yes
id
f89b981c-6dbc-4117-ac73-2476aa5aefbc
date added to LUP
2017-02-03 15:49:49
date last changed
2018-01-07 11:48:11
@article{f89b981c-6dbc-4117-ac73-2476aa5aefbc,
  abstract     = {<p>Severe infections are recognized complications of coeliac disease (CD). In the present study we aimed to examine whether individuals with CD are at increased risk of invasive pneumococcal disease (IPD). To do so, we performed a population-based cohort study including 29 012 individuals with biopsy-proven CD identified through biopsy reports from all pathology departments in Sweden. Each individual with CD was matched with up to five controls (n = 144 257). IPD events were identified through regional and national microbiological databases, including the National Surveillance System for Infectious Diseases. We used Cox regression analyses to estimate hazard ratios (HRs) for diagnosed IPD. A total of 207 individuals had a record of IPD whereas 45/29 012 had CD (0·15%) and 162/144 257 were controls (0·11%). This corresponded to a 46% increased risk for IPD [HR 1·46, 95% confidence interval (CI) 1·05-2·03]. The risk estimate was similar after adjustment for socioeconomic status, educational level and comorbidities, but then failed to attain statistical significance (adjusted HR 1·40, 95% CI 0·99-1·97). Nonetheless, our study shows a trend towards an increased risk for IPD in CD patients. The findings support results seen in earlier research and taking that into consideration individuals with CD may be considered for pneumococcal vaccination.</p>},
  author       = {Röckert Tjernberg, A and Bonnedahl, J and Inghammar, M and Egesten, A and Kahlmeter, G. and Nauclér, P and Henriques-Normark, B. and Ludvigsson, Jonas F.},
  issn         = {0950-2688},
  language     = {eng},
  month        = {01},
  number       = {6},
  pages        = {1203--1209},
  publisher    = {Cambridge University Press},
  series       = {Epidemiology and Infection},
  title        = {Coeliac disease and invasive pneumococcal disease : a population-based cohort study},
  url          = {http://dx.doi.org/10.1017/S0950268816003204},
  volume       = {145},
  year         = {2017},
}