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LEVELS OF IL-6 AND OTHER INFLAMMATORY PROTEINS IN EARLY RA PREDICT JOINT DAMAGE PROGRESSION OVER 5 YEARS

Rydell, Emil LU orcid ; Forslind, K. LU ; Jacobsson, Lennart LU and Turesson, Carl LU (2022) EULAR 2022 In Annals of the Rheumatic Diseases 81(Suppl. 1). p.504-505
Abstract
Background Joint damage in rheumatoid arthritis (RA) remains a significant problem. Identification of biomarkers associated with joint destruction can improve our understanding of underlying disease processes and future management.

Objectives To evaluate inflammatory proteins as potential predictors of radiographic progression of joint damage.

Methods Consecutive early RA patients (symptom duration 0.50 were investigated as potential predictors of radiographic progression. Logistic and linear regression models were used to assess associations with rapid radiographic progression (RRP; ≥5 SHS/year) and progression of SHS over 5 years.

Results Data on baseline levels of proteins, and radiographs at baseline and 5... (More)
Background Joint damage in rheumatoid arthritis (RA) remains a significant problem. Identification of biomarkers associated with joint destruction can improve our understanding of underlying disease processes and future management.

Objectives To evaluate inflammatory proteins as potential predictors of radiographic progression of joint damage.

Methods Consecutive early RA patients (symptom duration 0.50 were investigated as potential predictors of radiographic progression. Logistic and linear regression models were used to assess associations with rapid radiographic progression (RRP; ≥5 SHS/year) and progression of SHS over 5 years.

Results Data on baseline levels of proteins, and radiographs at baseline and 5 years were available for 114 patients. The median progression of SHS was 11 (interquartile 2-19). For potential biomarkers with an a priori hypothesis, IL-6 significantly predicted both RRP and progression of SHS over 5 years analyzed as a continuous variable [adjusted ß = 0.09 per SD, p=0.032, adjusted for rheumatoid factor (RF) and baseline SHS]. A significant positive association for matrix metalloproteinase 1 (MMP-1) was observed in the unadjusted analysis for SHS progression, but not for RRP (Table 1). In the exploratory analyses, S100 calcium-binding protein A12 (EN-RAGE) was positively, and TNF-related apoptosis-inducing ligand (TRAIL) negatively associated with both outcomes.

Conclusion Plasma levels of IL-6 at RA diagnosis predict degree of future joint damage. EN-RAGE and TRAIL, both modulators of NF-κB which is known to regulate immune response, are potential biomarkers that need further investigation. (Less)
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Annals of the Rheumatic Diseases
volume
81
issue
Suppl. 1
pages
504 - 505
publisher
BMJ Publishing Group
conference name
EULAR 2022
conference location
Copenhagen, Denmark
conference dates
2022-06-01 - 2022-06-04
ISSN
1468-2060
DOI
10.1136/annrheumdis-2022-eular.191
language
English
LU publication?
yes
id
f8a035ac-77d4-4117-ab2b-f48da25d243f
date added to LUP
2022-11-10 10:10:46
date last changed
2022-11-11 07:23:02
@misc{f8a035ac-77d4-4117-ab2b-f48da25d243f,
  abstract     = {{Background Joint damage in rheumatoid arthritis (RA) remains a significant problem. Identification of biomarkers associated with joint destruction can improve our understanding of underlying disease processes and future management.<br/><br/>Objectives To evaluate inflammatory proteins as potential predictors of radiographic progression of joint damage.<br/><br/>Methods Consecutive early RA patients (symptom duration 0.50 were investigated as potential predictors of radiographic progression. Logistic and linear regression models were used to assess associations with rapid radiographic progression (RRP; ≥5 SHS/year) and progression of SHS over 5 years.<br/><br/>Results Data on baseline levels of proteins, and radiographs at baseline and 5 years were available for 114 patients. The median progression of SHS was 11 (interquartile 2-19). For potential biomarkers with an a priori hypothesis, IL-6 significantly predicted both RRP and progression of SHS over 5 years analyzed as a continuous variable [adjusted ß = 0.09 per SD, p=0.032, adjusted for rheumatoid factor (RF) and baseline SHS]. A significant positive association for matrix metalloproteinase 1 (MMP-1) was observed in the unadjusted analysis for SHS progression, but not for RRP (Table 1). In the exploratory analyses, S100 calcium-binding protein A12 (EN-RAGE) was positively, and TNF-related apoptosis-inducing ligand (TRAIL) negatively associated with both outcomes.<br/><br/>Conclusion Plasma levels of IL-6 at RA diagnosis predict degree of future joint damage. EN-RAGE and TRAIL, both modulators of NF-κB which is known to regulate immune response, are potential biomarkers that need further investigation.}},
  author       = {{Rydell, Emil and Forslind, K. and Jacobsson, Lennart and Turesson, Carl}},
  issn         = {{1468-2060}},
  language     = {{eng}},
  note         = {{Conference Abstract}},
  number       = {{Suppl. 1}},
  pages        = {{504--505}},
  publisher    = {{BMJ Publishing Group}},
  series       = {{Annals of the Rheumatic Diseases}},
  title        = {{LEVELS OF IL-6 AND OTHER INFLAMMATORY PROTEINS IN EARLY RA PREDICT JOINT DAMAGE PROGRESSION OVER 5 YEARS}},
  url          = {{http://dx.doi.org/10.1136/annrheumdis-2022-eular.191}},
  doi          = {{10.1136/annrheumdis-2022-eular.191}},
  volume       = {{81}},
  year         = {{2022}},
}