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Dietary Polyphenols in the Aetiology of Crohn's Disease and Ulcerative Colitis-A Multicenter European Prospective Cohort Study (EPIC)

Lu, Yunxia; Zamora-Ros, Raul; Chan, Simon; Cross, Amanda J.; Ward, Heather; Jakszyn, Paula; Luben, Robert; Opstelten, Jorrit L.; Oldenburg, Bas and Hallmans, Göran, et al. (2017) In Inflammatory Bowel Diseases 23(12). p.2072-2082
Abstract

BACKGROUND: Oxidative stress may be involved in the aetiology of inflammatory bowel disease and whether dietary polyphenols, which possess antioxidants properties, prevent its development is unknown.

METHODS: A total of 401,326 men and women aged 20 to 80 years from 8 countries were recruited between 1991 and 1998 and at baseline completed validated food frequency questionnaires. Dietary polyphenol intake was measured using Phenol-Explorer, a database with information on the content of 502 polyphenols. Incident cases of Crohn's diseases (CD) and ulcerative colitis (UC) were identified during the follow-up period of up to December 2010. A nested case-control study using conditional logistic regression estimated the odds ratios... (More)

BACKGROUND: Oxidative stress may be involved in the aetiology of inflammatory bowel disease and whether dietary polyphenols, which possess antioxidants properties, prevent its development is unknown.

METHODS: A total of 401,326 men and women aged 20 to 80 years from 8 countries were recruited between 1991 and 1998 and at baseline completed validated food frequency questionnaires. Dietary polyphenol intake was measured using Phenol-Explorer, a database with information on the content of 502 polyphenols. Incident cases of Crohn's diseases (CD) and ulcerative colitis (UC) were identified during the follow-up period of up to December 2010. A nested case-control study using conditional logistic regression estimated the odds ratios (ORs), and 95% confidence intervals, for polyphenol intake (categories based on quartiles) and developing CD or UC.

RESULTS: In total, 110 CD (73% women) and 244 UC (57% women) cases were identified and matched to 440 and 976 controls, respectively. Total polyphenol intake was not associated with CD (P trend = 0.17) or UC (P trend = 0.16). For flavones and CD, there were reduced odds for all quartiles, which were statistically significant for the third (OR3rd versus 1st quartile = 0.33; 95% confidence interval, 0.15-0.69) and there was an inverse trend across quartiles (P = 0.03). Similarly, for resveratrol, there was an inverse association with CD (OR4th versus 1st quartile = 0.40; 95% confidence interval, 0.20-0.82) with an inverse trend across quartiles (P = 0.02). No significant associations between subtypes of polyphenols and UC were found. Effect modification by smoking in CD was documented with borderline statistical significance.

CONCLUSIONS: The data supports a potential role of flavones and resveratrol in the risk of developing CD; future aetiological studies should investigate these dietary components and further examine the potential for residual confounding.

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published
subject
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Inflammatory Bowel Diseases
volume
23
issue
12
pages
11 pages
publisher
John Wiley & Sons
external identifiers
  • scopus:85047559286
ISSN
1536-4844
DOI
10.1097/MIB.0000000000001108
language
English
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yes
id
f8a3dfa5-3ebc-4051-9d40-c69f2324dc9c
date added to LUP
2019-06-27 07:50:42
date last changed
2019-08-14 04:40:43
@article{f8a3dfa5-3ebc-4051-9d40-c69f2324dc9c,
  abstract     = {<p>BACKGROUND: Oxidative stress may be involved in the aetiology of inflammatory bowel disease and whether dietary polyphenols, which possess antioxidants properties, prevent its development is unknown.</p><p>METHODS: A total of 401,326 men and women aged 20 to 80 years from 8 countries were recruited between 1991 and 1998 and at baseline completed validated food frequency questionnaires. Dietary polyphenol intake was measured using Phenol-Explorer, a database with information on the content of 502 polyphenols. Incident cases of Crohn's diseases (CD) and ulcerative colitis (UC) were identified during the follow-up period of up to December 2010. A nested case-control study using conditional logistic regression estimated the odds ratios (ORs), and 95% confidence intervals, for polyphenol intake (categories based on quartiles) and developing CD or UC.</p><p>RESULTS: In total, 110 CD (73% women) and 244 UC (57% women) cases were identified and matched to 440 and 976 controls, respectively. Total polyphenol intake was not associated with CD (P trend = 0.17) or UC (P trend = 0.16). For flavones and CD, there were reduced odds for all quartiles, which were statistically significant for the third (OR3rd versus 1st quartile = 0.33; 95% confidence interval, 0.15-0.69) and there was an inverse trend across quartiles (P = 0.03). Similarly, for resveratrol, there was an inverse association with CD (OR4th versus 1st quartile = 0.40; 95% confidence interval, 0.20-0.82) with an inverse trend across quartiles (P = 0.02). No significant associations between subtypes of polyphenols and UC were found. Effect modification by smoking in CD was documented with borderline statistical significance.</p><p>CONCLUSIONS: The data supports a potential role of flavones and resveratrol in the risk of developing CD; future aetiological studies should investigate these dietary components and further examine the potential for residual confounding.</p>},
  author       = {Lu, Yunxia and Zamora-Ros, Raul and Chan, Simon and Cross, Amanda J. and Ward, Heather and Jakszyn, Paula and Luben, Robert and Opstelten, Jorrit L. and Oldenburg, Bas and Hallmans, Göran and Karling, Pontus and Grip, Olof and Key, Timothy and Bergmann, Manuela M. and Boeing, Heiner and Overvad, Kim and Palli, Domenico and Masala, Giovanna and Khaw, Kay Tee and Racine, Antoine and Carbonnel, Franck and Boutron-Ruault, Marie Christine and Andersen, Vibeke and Olsen, Anja and Tjonneland, Anne and Kaaks, Rudolf and Tumino, Rosario and Trichopoulou, Antonia and Scalbert, Augustin and Riboli, Elio and Hart, Andrew R.},
  issn         = {1536-4844},
  language     = {eng},
  month        = {12},
  number       = {12},
  pages        = {2072--2082},
  publisher    = {John Wiley & Sons},
  series       = {Inflammatory Bowel Diseases},
  title        = {Dietary Polyphenols in the Aetiology of Crohn's Disease and Ulcerative Colitis-A Multicenter European Prospective Cohort Study (EPIC)},
  url          = {http://dx.doi.org/10.1097/MIB.0000000000001108},
  volume       = {23},
  year         = {2017},
}