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Effectiveness of the Q fever vaccine : A meta-analysis

Gefenaite, G. LU ; Munster, J. M. ; van Houdt, R. and Hak, E. (2011) In Vaccine 29(3). p.395-398
Abstract

In the Netherlands, the number of notified human Q fever cases showed a steep increase over the last three years and is not expected to disappear in the next few years. Since vaccination might be an option to prevent Q fever cases in the general population, evidence is needed about its effectiveness. We therefore conducted a meta-analysis to determine the evidence base for effectiveness for Q fever vaccination in human populations. We calculated Mantel-Haenszel risk ratios and we used the following formula to calculate the vaccines effectiveness: (1 - mhRR)×100%. Although individual and the pooled estimates showed a high effectiveness of Q fever vaccine, conclusions for the general population cannot be confidently drawn about vaccine... (More)

In the Netherlands, the number of notified human Q fever cases showed a steep increase over the last three years and is not expected to disappear in the next few years. Since vaccination might be an option to prevent Q fever cases in the general population, evidence is needed about its effectiveness. We therefore conducted a meta-analysis to determine the evidence base for effectiveness for Q fever vaccination in human populations. We calculated Mantel-Haenszel risk ratios and we used the following formula to calculate the vaccines effectiveness: (1 - mhRR)×100%. Although individual and the pooled estimates showed a high effectiveness of Q fever vaccine, conclusions for the general population cannot be confidently drawn about vaccine effectiveness due to potential flaws in the design of the studies and the selected group of study participants.

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author
; ; and
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Effectiveness, Q fever, Vaccination
in
Vaccine
volume
29
issue
3
pages
395 - 398
publisher
Elsevier
external identifiers
  • scopus:78650519317
  • pmid:21094268
ISSN
0264-410X
DOI
10.1016/j.vaccine.2010.11.008
language
English
LU publication?
no
id
f910834a-940e-4622-9e3c-25b6f015bf62
date added to LUP
2020-05-14 14:30:13
date last changed
2021-01-12 01:06:04
@article{f910834a-940e-4622-9e3c-25b6f015bf62,
  abstract     = {<p>In the Netherlands, the number of notified human Q fever cases showed a steep increase over the last three years and is not expected to disappear in the next few years. Since vaccination might be an option to prevent Q fever cases in the general population, evidence is needed about its effectiveness. We therefore conducted a meta-analysis to determine the evidence base for effectiveness for Q fever vaccination in human populations. We calculated Mantel-Haenszel risk ratios and we used the following formula to calculate the vaccines effectiveness: (1 - mhRR)×100%. Although individual and the pooled estimates showed a high effectiveness of Q fever vaccine, conclusions for the general population cannot be confidently drawn about vaccine effectiveness due to potential flaws in the design of the studies and the selected group of study participants.</p>},
  author       = {Gefenaite, G. and Munster, J. M. and van Houdt, R. and Hak, E.},
  issn         = {0264-410X},
  language     = {eng},
  month        = {01},
  number       = {3},
  pages        = {395--398},
  publisher    = {Elsevier},
  series       = {Vaccine},
  title        = {Effectiveness of the Q fever vaccine : A meta-analysis},
  url          = {http://dx.doi.org/10.1016/j.vaccine.2010.11.008},
  doi          = {10.1016/j.vaccine.2010.11.008},
  volume       = {29},
  year         = {2011},
}