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Suppressed natural killer cell activity in patients with chronic autoimmune thrombocytopenic purpura

Semple, John W. LU ; Bruce, Suzanne and Freedman, John (1991) In American Journal of Hematology 37(4). p.258-262
Abstract

Natural killer (NK) cell activity was studied in 17 patients with primary chronic idiopathic autoimmune thrombocytopenic purpura (ATP). Fifteen of 17 patients had a significantly reduced NK cytotoxicity against 51chromium labeled K562 target cells (mean LU20% = 18 ± 20 in patients versus 65 = 2 5 in controls, P < 0.001). NK activity was also significantly reduced in all of six patients with secondary ATP as compared with normal controls (LU20%28±15, respectively, P < 0.005). The NK activity in both patient groups correlated with the duration of therapy being received (r = 0.60, P < 0.001). Immunophenotypic analysis of peripheral blood mononuclear cells from patients with ATP revealed that CD8‐... (More)

Natural killer (NK) cell activity was studied in 17 patients with primary chronic idiopathic autoimmune thrombocytopenic purpura (ATP). Fifteen of 17 patients had a significantly reduced NK cytotoxicity against 51chromium labeled K562 target cells (mean LU20% = 18 ± 20 in patients versus 65 = 2 5 in controls, P < 0.001). NK activity was also significantly reduced in all of six patients with secondary ATP as compared with normal controls (LU20%28±15, respectively, P < 0.005). The NK activity in both patient groups correlated with the duration of therapy being received (r = 0.60, P < 0.001). Immunophenotypic analysis of peripheral blood mononuclear cells from patients with ATP revealed that CD8‐ cells bearing CD57 (HNK‐1, Leu 7) and CD3‐ cells bearing CD56 (Leu 19) were quantitatively within the normal range. These findings indicate that patients with ATP have a functional defect in NK cytolytic activity.

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author
; and
publishing date
type
Contribution to journal
publication status
published
subject
keywords
autoimmunity, natural killer cells, thrombocytopenia
in
American Journal of Hematology
volume
37
issue
4
pages
258 - 262
publisher
John Wiley & Sons Inc.
external identifiers
  • pmid:1858783
  • scopus:0025816682
ISSN
0361-8609
DOI
10.1002/ajh.2830370409
language
English
LU publication?
no
id
f950adf4-a52b-4c94-bd94-d7f73dc46bfd
date added to LUP
2019-12-03 10:36:29
date last changed
2025-07-26 09:55:33
@article{f950adf4-a52b-4c94-bd94-d7f73dc46bfd,
  abstract     = {{<p>Natural killer (NK) cell activity was studied in 17 patients with primary chronic idiopathic autoimmune thrombocytopenic purpura (ATP). Fifteen of 17 patients had a significantly reduced NK cytotoxicity against <sup>51</sup>chromium labeled K562 target cells (mean LU<sub>20%</sub> = 18 ± 20 in patients versus 65 = 2 5 in controls, P &lt; 0.001). NK activity was also significantly reduced in all of six patients with secondary ATP as compared with normal controls (LU<sub>20%</sub>28±15, respectively, P &lt; 0.005). The NK activity in both patient groups correlated with the duration of therapy being received (r = 0.60, P &lt; 0.001). Immunophenotypic analysis of peripheral blood mononuclear cells from patients with ATP revealed that CD8‐ cells bearing CD57 (HNK‐1, Leu 7) and CD3‐ cells bearing CD56 (Leu 19) were quantitatively within the normal range. These findings indicate that patients with ATP have a functional defect in NK cytolytic activity.</p>}},
  author       = {{Semple, John W. and Bruce, Suzanne and Freedman, John}},
  issn         = {{0361-8609}},
  keywords     = {{autoimmunity; natural killer cells; thrombocytopenia}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{4}},
  pages        = {{258--262}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{American Journal of Hematology}},
  title        = {{Suppressed natural killer cell activity in patients with chronic autoimmune thrombocytopenic purpura}},
  url          = {{http://dx.doi.org/10.1002/ajh.2830370409}},
  doi          = {{10.1002/ajh.2830370409}},
  volume       = {{37}},
  year         = {{1991}},
}