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Progress towards Clinical Use of iPS Cell Derived Therapies

Kele, Malin and Falk, Anna LU (2016) In International Journal of Stem Cell Research & Therapy
Abstract
A decade has passed since Shinya Yamanaka published his
landmarking publication on how to produce pluripotent stem-
cell-like cells and the term induced pluripotent stem cells, iPS
cells, was coined. This past decade has been a decade devoted
to pluripotent cells, scrutinizing molecular mechanisms in cell
identity, and optimizing derivation methods, culture conditions
and characterization methods to xenofree and chemically defined
clinical-grade pluripotent stem cells. The early promises of
autologous cell therapies are now replaced by creation of highly
selected donor cell banks matched to provide cells for the majority
of a target ... (More)
A decade has passed since Shinya Yamanaka published his
landmarking publication on how to produce pluripotent stem-
cell-like cells and the term induced pluripotent stem cells, iPS
cells, was coined. This past decade has been a decade devoted
to pluripotent cells, scrutinizing molecular mechanisms in cell
identity, and optimizing derivation methods, culture conditions
and characterization methods to xenofree and chemically defined
clinical-grade pluripotent stem cells. The early promises of
autologous cell therapies are now replaced by creation of highly
selected donor cell banks matched to provide cells for the majority
of a target population. Several of the initial safety concerns with
iPS cells have been addressed with the use of non-integrating
derivation methods and chemically defined and xenofree culture
conditions, but some remain and will not be fully resolved until
conclusions from in vivo experiments in larger animal models
can be made. Published studies on safety and proof of concept
performed in nonhuman primates are few but show promising
results for spinal cord injury and Parkinson’s disease for example.
But questions remain; on how to provide functional and long-term
integrating grafts and whether these can fulfill the promises of
recovery and potential cure? (Less)
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International Journal of Stem Cell Research & Therapy
publisher
ClinMed International Library
ISSN
2469-570X
language
English
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no
id
f98e781e-fc88-4a02-abd9-0d9d27bac6bd
date added to LUP
2021-08-10 14:11:10
date last changed
2021-08-12 14:31:53
@misc{f98e781e-fc88-4a02-abd9-0d9d27bac6bd,
  abstract     = {{A  decade  has  passed  since  Shinya  Yamanaka  published  his  <br/>landmarking publication on how to produce pluripotent stem-<br/>cell-like  cells  and  the  term  induced  pluripotent  stem  cells,  iPS  <br/>cells,  was  coined.  This  past  decade  has  been  a  decade  devoted  <br/>to  pluripotent  cells,  scrutinizing  molecular  mechanisms  in  cell  <br/>identity,  and  optimizing  derivation  methods,  culture  conditions  <br/>and characterization methods to xenofree and chemically defined <br/>clinical-grade pluripotent stem cells. The early promises of <br/>autologous  cell  therapies  are  now  replaced  by  creation  of  highly  <br/>selected donor cell banks matched to provide cells for the majority <br/>of  a  target  population.  Several  of  the  initial  safety  concerns  with  <br/>iPS  cells  have  been  addressed  with  the  use  of  non-integrating  <br/>derivation methods and chemically defined and xenofree culture <br/>conditions,  but  some  remain  and  will  not  be  fully  resolved  until  <br/>conclusions  from  in  vivo  experiments  in  larger  animal  models  <br/>can  be  made.  Published  studies  on  safety  and  proof  of  concept  <br/>performed  in  nonhuman  primates  are  few  but  show  promising  <br/>results for spinal cord injury and Parkinson’s disease for example. <br/>But questions remain; on how to provide functional and long-term <br/>integrating  grafts  and  whether  these  can  fulfill  the  promises  of <br/>recovery and potential cure?}},
  author       = {{Kele, Malin and Falk, Anna}},
  issn         = {{2469-570X}},
  language     = {{eng}},
  note         = {{Review}},
  publisher    = {{ClinMed International Library}},
  series       = {{International Journal of Stem Cell Research & Therapy}},
  title        = {{Progress towards Clinical Use of iPS Cell Derived Therapies}},
  url          = {{https://lup.lub.lu.se/search/files/101078546/Progress_towards_Clinical_Use_.pdf}},
  year         = {{2016}},
}