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Influence of geolocation and ethnicity on the phenotypic expression of primary Sjögren's syndrome at diagnosis in 8310 patients : A cross-sectional study from the Big Data Sjögren Project Consortium

Brito-Zerón, Pilar; Acar-Denizli, Nihan; Zeher, Margit; Rasmussen, Astrid; Seror, Raphaele; Theander, Elke LU ; Li, Xiaomei; Baldini, Chiara; Gottenberg, Jacques Eric and Danda, Debashish, et al. (2017) In Annals of the Rheumatic Diseases 76. p.1042-1050
Abstract

Objectives To analyse the influence of geolocation and ethnicity on the clinical presentation of primary Sjögren's syndrome (SjS) at diagnosis. Methods The Big Data Sjögren Project Consortium is an international, multicentre registry designed in 2014. By January 2016, 20 centres from five continents were participating. Multivariable logistic regression analyses were performed. Results We included 7748 women (93%) and 562 men (7%), with a mean age at diagnosis of primary SjS of 53 years. Ethnicity data were available for 7884 patients (95%): 6174 patients (78%) were white, 1066 patients (14%) were Asian, 393 patients (5%) were Hispanic, 104 patients (1%) were black/African- American and 147 patients (2%) were of other ethnicities. SjS... (More)

Objectives To analyse the influence of geolocation and ethnicity on the clinical presentation of primary Sjögren's syndrome (SjS) at diagnosis. Methods The Big Data Sjögren Project Consortium is an international, multicentre registry designed in 2014. By January 2016, 20 centres from five continents were participating. Multivariable logistic regression analyses were performed. Results We included 7748 women (93%) and 562 men (7%), with a mean age at diagnosis of primary SjS of 53 years. Ethnicity data were available for 7884 patients (95%): 6174 patients (78%) were white, 1066 patients (14%) were Asian, 393 patients (5%) were Hispanic, 104 patients (1%) were black/African- American and 147 patients (2%) were of other ethnicities. SjS was diagnosed a mean of 7 years earlier in black/African-American compared with white patients; the female-to-male ratio was highest in Asian patients (27:1) and lowest in black/African-American patients (7:1); the prevalence of sicca symptoms was lowest in Asian patients; a higher frequency of positive salivary biopsy was found in Hispanic and white patients. A north-south gradient was found with respect to a lower frequency of ocular involvement in northern countries for dry eyes and abnormal ocular tests in Europe (OR 0.46 and 0.44, respectively) and Asia (OR 0.18 and 0.49, respectively) compared with southern countries. Higher frequencies of antinuclear antibodies (ANAs) were reported in northern countries in America (OR=1.48) and Asia (OR=3.80) while, in Europe, northern countries had lowest frequencies of ANAs (OR=0.67) and Ro/La (OR=0.69). Conclusions This study provides the first evidence of a strong influence of geolocation and ethnicity on the phenotype of primary SjS at diagnosis.

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Annals of the Rheumatic Diseases
volume
76
pages
1042 - 1050
publisher
British Medical Association
external identifiers
  • scopus:85006013155
  • wos:000401138800017
ISSN
0003-4967
DOI
10.1136/annrheumdis-2016-209952
language
English
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yes
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f9b68396-477e-4c0f-a83f-31082d4c81a4
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2016-12-29 10:37:04
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2018-03-25 04:32:43
@article{f9b68396-477e-4c0f-a83f-31082d4c81a4,
  abstract     = {<p>Objectives To analyse the influence of geolocation and ethnicity on the clinical presentation of primary Sjögren's syndrome (SjS) at diagnosis. Methods The Big Data Sjögren Project Consortium is an international, multicentre registry designed in 2014. By January 2016, 20 centres from five continents were participating. Multivariable logistic regression analyses were performed. Results We included 7748 women (93%) and 562 men (7%), with a mean age at diagnosis of primary SjS of 53 years. Ethnicity data were available for 7884 patients (95%): 6174 patients (78%) were white, 1066 patients (14%) were Asian, 393 patients (5%) were Hispanic, 104 patients (1%) were black/African- American and 147 patients (2%) were of other ethnicities. SjS was diagnosed a mean of 7 years earlier in black/African-American compared with white patients; the female-to-male ratio was highest in Asian patients (27:1) and lowest in black/African-American patients (7:1); the prevalence of sicca symptoms was lowest in Asian patients; a higher frequency of positive salivary biopsy was found in Hispanic and white patients. A north-south gradient was found with respect to a lower frequency of ocular involvement in northern countries for dry eyes and abnormal ocular tests in Europe (OR 0.46 and 0.44, respectively) and Asia (OR 0.18 and 0.49, respectively) compared with southern countries. Higher frequencies of antinuclear antibodies (ANAs) were reported in northern countries in America (OR=1.48) and Asia (OR=3.80) while, in Europe, northern countries had lowest frequencies of ANAs (OR=0.67) and Ro/La (OR=0.69). Conclusions This study provides the first evidence of a strong influence of geolocation and ethnicity on the phenotype of primary SjS at diagnosis.</p>},
  author       = {Brito-Zerón, Pilar and Acar-Denizli, Nihan and Zeher, Margit and Rasmussen, Astrid and Seror, Raphaele and Theander, Elke and Li, Xiaomei and Baldini, Chiara and Gottenberg, Jacques Eric and Danda, Debashish and Quartuccio, Luca and Priori, Roberta and Hernandez-Molina, Gabriela and Kruize, Aike A. and Valim, Valeria and Kvarnstrom, Marika and Sene, Damien and Gerli, Roberto and Praprotnik, Sonja and Isenberg, David and Solans, Roser and Rischmueller, Maureen and Kwok, Seung Ki and Nordmark, Gunnel and Suzuki, Yasunori and Giacomelli, Roberto and Devauchelle-Pensec, Valerie and Bombardieri, Michele and Hofauer, Benedikt and Bootsma, Hendrika and Brun, Johan G. and Fraile, Guadalupe and Carsons, Steven E. and Gheita, Tamer A. and Morel, Jacques and Vollenveider, Cristina and Atzeni, Fabiola and Retamozo, Soledad and Horvath, Ildiko Fanny and Sivils, Kathy and Mandl, Thomas and Sandhya, Pulukool and Vita, Salvatore De and Sanchez-Guerrero, Jorge and van der Heijden, Eefje and Moça Trevisani, Virginia Fernandes and Wahren-Herlenius, Marie and Mariette, Xavier and Ramos-Casals, Manuel},
  issn         = {0003-4967},
  language     = {eng},
  pages        = {1042--1050},
  publisher    = {British Medical Association},
  series       = {Annals of the Rheumatic Diseases},
  title        = {Influence of geolocation and ethnicity on the phenotypic expression of primary Sjögren's syndrome at diagnosis in 8310 patients : A cross-sectional study from the Big Data Sjögren Project Consortium},
  url          = {http://dx.doi.org/10.1136/annrheumdis-2016-209952},
  volume       = {76},
  year         = {2017},
}