The frequency and influence of dementia risk factors in prodromal Alzheimer's disease
(2017) In Neurobiology of Aging 56. p.33-40- Abstract
We investigated whether dementia risk factors were associated with prodromal Alzheimer's disease (AD) according to the International Working Group-2 and National Institute of Aging-Alzheimer's Association criteria, and with cognitive decline. A total of 1394 subjects with mild cognitive impairment from 14 different studies were classified according to these research criteria, based on cognitive performance and biomarkers. We compared the frequency of 10 risk factors between the subgroups, and used Cox-regression to examine the effect of risk factors on cognitive decline. Depression, obesity, and hypercholesterolemia occurred more often in individuals with low-AD-likelihood, compared with those with a high-AD-likelihood. Only alcohol use... (More)
We investigated whether dementia risk factors were associated with prodromal Alzheimer's disease (AD) according to the International Working Group-2 and National Institute of Aging-Alzheimer's Association criteria, and with cognitive decline. A total of 1394 subjects with mild cognitive impairment from 14 different studies were classified according to these research criteria, based on cognitive performance and biomarkers. We compared the frequency of 10 risk factors between the subgroups, and used Cox-regression to examine the effect of risk factors on cognitive decline. Depression, obesity, and hypercholesterolemia occurred more often in individuals with low-AD-likelihood, compared with those with a high-AD-likelihood. Only alcohol use increased the risk of cognitive decline, regardless of AD pathology. These results suggest that traditional risk factors for AD are not associated with prodromal AD or with progression to dementia, among subjects with mild cognitive impairment. Future studies should validate these findings and determine whether risk factors might be of influence at an earlier stage (i.e., preclinical) of AD.
(Less)
- author
- organization
- publishing date
- 2017-08-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Alzheimer's disease, Biomarkers, IWG-2 criteria, NIA-AA criteria, Prognosis, Risk factors
- in
- Neurobiology of Aging
- volume
- 56
- pages
- 33 - 40
- publisher
- Elsevier
- external identifiers
-
- scopus:85018725939
- pmid:28482212
- wos:000405463300005
- ISSN
- 0197-4580
- DOI
- 10.1016/j.neurobiolaging.2017.03.034
- language
- English
- LU publication?
- yes
- id
- f9eda6d8-d679-4d81-b560-6c3801a70540
- date added to LUP
- 2017-06-07 14:49:32
- date last changed
- 2025-02-03 17:17:22
@article{f9eda6d8-d679-4d81-b560-6c3801a70540, abstract = {{<p>We investigated whether dementia risk factors were associated with prodromal Alzheimer's disease (AD) according to the International Working Group-2 and National Institute of Aging-Alzheimer's Association criteria, and with cognitive decline. A total of 1394 subjects with mild cognitive impairment from 14 different studies were classified according to these research criteria, based on cognitive performance and biomarkers. We compared the frequency of 10 risk factors between the subgroups, and used Cox-regression to examine the effect of risk factors on cognitive decline. Depression, obesity, and hypercholesterolemia occurred more often in individuals with low-AD-likelihood, compared with those with a high-AD-likelihood. Only alcohol use increased the risk of cognitive decline, regardless of AD pathology. These results suggest that traditional risk factors for AD are not associated with prodromal AD or with progression to dementia, among subjects with mild cognitive impairment. Future studies should validate these findings and determine whether risk factors might be of influence at an earlier stage (i.e., preclinical) of AD.</p>}}, author = {{Bos, Isabelle and Vos, Stephanie J B and Frölich, Lutz and Kornhuber, Johannes and Wiltfang, Jens and Maier, Wolfgang and Peters, Oliver and Rüther, Eckhart and Engelborghs, Sebastiaan and Niemantsverdriet, Ellis and De Roeck, Ellen Elisa and Tsolaki, Magda and Freund-Levi, Yvonne and Johannsen, Peter and Vandenberghe, Rik and Lleó, Alberto and Alcolea, Daniel and Frisoni, Giovanni B and Galluzzi, Samantha and Nobili, Flavio and Morbelli, Silvia and Drzezga, Alexander and Didic, Mira and van Berckel, Bart N M and Salmon, Eric and Bastin, Christine and Dauby, Solene and Santana, Isabel and Baldeiras, Inês and de Mendonça, Alexandre and Silva, Dina and Wallin, Anders and Nordlund, Arto and Coloma, Preciosa M. and Wientzek, Angelika and Alexander, Myriam and Novak, Gerald P and Gordon, Mark Forrest and Wallin, Åsa K. and Hampel, Harald and Soininen, Hilkka and Herukka, Sanna-Kaisa and Scheltens, Philip and Verhey, Frans Rj and Visser, Pieter Jelle}}, issn = {{0197-4580}}, keywords = {{Alzheimer's disease; Biomarkers; IWG-2 criteria; NIA-AA criteria; Prognosis; Risk factors}}, language = {{eng}}, month = {{08}}, pages = {{33--40}}, publisher = {{Elsevier}}, series = {{Neurobiology of Aging}}, title = {{The frequency and influence of dementia risk factors in prodromal Alzheimer's disease}}, url = {{http://dx.doi.org/10.1016/j.neurobiolaging.2017.03.034}}, doi = {{10.1016/j.neurobiolaging.2017.03.034}}, volume = {{56}}, year = {{2017}}, }