Deviations in delineated GTV caused by artefacts in 4DCT
Persson, Gitte Fredberg ; Nygaard, Ditte Eklund ; Brink, Carsten ; Jahn, Jonas Westberg ; Munck af Rosenschöld, Per LU
; Specht, Lena
and Korreman, Stine Sofia
(2010)
In Radiotherapy and Oncology
96(1).
p.61-66
- Abstract
Background and purpose: Four-dimensional computed tomography (4DCT) is used for breathing-adapted radiotherapy planning. Irregular breathing, large tumour motion or interpolation of images can cause artefacts in the 4DCT. This study evaluates the impact of artefacts on gross tumour volume (GTV) size. Material and methods: In 19 4DCT scans of patients with peripheral lung tumours, GTV was delineated in all bins. Variations in GTV size between bins in each 4DCT scan were analysed and correlated to tumour motion and variations in breathing signal amplitude and breathing signal period. End-expiration GTV size (GTVexp) was considered as reference for GTV size. Intra-session delineation error was estimated by re-delineation of GTV in eight of... (More)
Background and purpose: Four-dimensional computed tomography (4DCT) is used for breathing-adapted radiotherapy planning. Irregular breathing, large tumour motion or interpolation of images can cause artefacts in the 4DCT. This study evaluates the impact of artefacts on gross tumour volume (GTV) size. Material and methods: In 19 4DCT scans of patients with peripheral lung tumours, GTV was delineated in all bins. Variations in GTV size between bins in each 4DCT scan were analysed and correlated to tumour motion and variations in breathing signal amplitude and breathing signal period. End-expiration GTV size (GTVexp) was considered as reference for GTV size. Intra-session delineation error was estimated by re-delineation of GTV in eight of the 4DCT scans. Results: In 16 of the 4DCT scans the maximum deviations from GTVexp were larger than could be explained by delineation error. The deviations were largest in the bins adjacent to the end-inspiration bin. The coefficient of variation of GTV size was significantly correlated to tumour motion in the cranio-caudal direction, but no significant correlation was found to breathing signal variations. Conclusion: We found considerable variations in GTV size throughout the 4DCT scans. Awareness of the error introduced by artefacts is important especially if radiotherapy planning is based on a single 4DCT bin.
(Less)
- author
- Persson, Gitte Fredberg
; Nygaard, Ditte Eklund
; Brink, Carsten
; Jahn, Jonas Westberg
; Munck af Rosenschöld, Per
LU
; Specht, Lena
and Korreman, Stine Sofia
- publishing date
- 2010-07
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- 4DCT, Artefacts, GTV, Lung cancer
- in
- Radiotherapy and Oncology
- volume
- 96
- issue
- 1
- pages
- 61 - 66
- publisher
- Elsevier
- external identifiers
-
- pmid:20570002
- scopus:77953962041
- ISSN
- 0167-8140
- DOI
- 10.1016/j.radonc.2010.04.019
- language
- English
- LU publication?
- no
- additional info
- Funding Information: This work has been supported by grants from the following institutions: The Danish research council , the Lundbeck Foundation Center for interventional Research in Radiation Oncology (CIRRO) and Varian Medical Systems .
- id
- fa05ebda-6261-4387-ba44-fbe2c8757f96
- date added to LUP
- 2023-07-19 17:14:59
- date last changed
- 2024-04-19 23:47:19
@article{fa05ebda-6261-4387-ba44-fbe2c8757f96,
abstract = {{<p>Background and purpose: Four-dimensional computed tomography (4DCT) is used for breathing-adapted radiotherapy planning. Irregular breathing, large tumour motion or interpolation of images can cause artefacts in the 4DCT. This study evaluates the impact of artefacts on gross tumour volume (GTV) size. Material and methods: In 19 4DCT scans of patients with peripheral lung tumours, GTV was delineated in all bins. Variations in GTV size between bins in each 4DCT scan were analysed and correlated to tumour motion and variations in breathing signal amplitude and breathing signal period. End-expiration GTV size (GTVexp) was considered as reference for GTV size. Intra-session delineation error was estimated by re-delineation of GTV in eight of the 4DCT scans. Results: In 16 of the 4DCT scans the maximum deviations from GTVexp were larger than could be explained by delineation error. The deviations were largest in the bins adjacent to the end-inspiration bin. The coefficient of variation of GTV size was significantly correlated to tumour motion in the cranio-caudal direction, but no significant correlation was found to breathing signal variations. Conclusion: We found considerable variations in GTV size throughout the 4DCT scans. Awareness of the error introduced by artefacts is important especially if radiotherapy planning is based on a single 4DCT bin.</p>}},
author = {{Persson, Gitte Fredberg and Nygaard, Ditte Eklund and Brink, Carsten and Jahn, Jonas Westberg and Munck af Rosenschöld, Per and Specht, Lena and Korreman, Stine Sofia}},
issn = {{0167-8140}},
keywords = {{4DCT; Artefacts; GTV; Lung cancer}},
language = {{eng}},
number = {{1}},
pages = {{61--66}},
publisher = {{Elsevier}},
series = {{Radiotherapy and Oncology}},
title = {{Deviations in delineated GTV caused by artefacts in 4DCT}},
url = {{http://dx.doi.org/10.1016/j.radonc.2010.04.019}},
doi = {{10.1016/j.radonc.2010.04.019}},
volume = {{96}},
year = {{2010}},
}