Changes in Practice of Controlled Hypothermia after Cardiac Arrest in the Past 20 Years : A Critical Care Perspective
(2023) In American Journal of Respiratory and Critical Care Medicine 207(12). p.1558-1564- Abstract
For 20 years, induced hypothermia and targeted temperature management have been recommended to mitigate brain injury and increase survival after cardiac arrest. On the basis of animal research and small clinical trials, the International Liaison Committee on Resuscitation strongly advocated hypothermia at 32-34 °C for 12-24 hours for comatose patients with out-of-hospital cardiac arrest with initial rhythm of ventricular fibrillation or nonperfusing ventricular tachycardia. The intervention was implemented worldwide. In the past decade, hypothermia and targeted temperature management have been investigated in larger clinical randomized trials focusing on target temperature depth, target temperature duration, prehospital versus... (More)
For 20 years, induced hypothermia and targeted temperature management have been recommended to mitigate brain injury and increase survival after cardiac arrest. On the basis of animal research and small clinical trials, the International Liaison Committee on Resuscitation strongly advocated hypothermia at 32-34 °C for 12-24 hours for comatose patients with out-of-hospital cardiac arrest with initial rhythm of ventricular fibrillation or nonperfusing ventricular tachycardia. The intervention was implemented worldwide. In the past decade, hypothermia and targeted temperature management have been investigated in larger clinical randomized trials focusing on target temperature depth, target temperature duration, prehospital versus in-hospital initiation, nonshockable rhythms, and in-hospital cardiac arrest. Systematic reviews suggest little or no effect of delivering the intervention on the basis of the summary of evidence, and the International Liaison Committee on Resuscitation today recommends only to treat fever and keep body temperature below 37.5 °C (weak recommendation, low-certainty evidence). Here we describe the evolution of temperature management for patients with cardiac arrest during the past 20 years and how the accrued evidence has influenced not only the recommendations but also the guideline process. We also discuss possible paths forward in this field, bringing up both whether fever management is at all beneficial for patients with cardiac arrest and which knowledge gaps future clinical trials in temperature management should address.
(Less)
- author
- Nielsen, Niklas LU and Friberg, Hans LU
- organization
- publishing date
- 2023-06
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- cardiac arrest, functional outcome, heart arrest, hypothermia, targeted temperature management
- in
- American Journal of Respiratory and Critical Care Medicine
- volume
- 207
- issue
- 12
- pages
- 7 pages
- publisher
- American Thoracic Society
- external identifiers
-
- pmid:37104654
- scopus:85163914178
- ISSN
- 1535-4970
- DOI
- 10.1164/rccm.202211-2142CP
- language
- English
- LU publication?
- yes
- id
- fa2d7afc-1261-4ccd-967b-99ae87ccdb60
- date added to LUP
- 2023-09-15 10:15:39
- date last changed
- 2024-04-20 03:19:20
@article{fa2d7afc-1261-4ccd-967b-99ae87ccdb60,
abstract = {{<p>For 20 years, induced hypothermia and targeted temperature management have been recommended to mitigate brain injury and increase survival after cardiac arrest. On the basis of animal research and small clinical trials, the International Liaison Committee on Resuscitation strongly advocated hypothermia at 32-34 °C for 12-24 hours for comatose patients with out-of-hospital cardiac arrest with initial rhythm of ventricular fibrillation or nonperfusing ventricular tachycardia. The intervention was implemented worldwide. In the past decade, hypothermia and targeted temperature management have been investigated in larger clinical randomized trials focusing on target temperature depth, target temperature duration, prehospital versus in-hospital initiation, nonshockable rhythms, and in-hospital cardiac arrest. Systematic reviews suggest little or no effect of delivering the intervention on the basis of the summary of evidence, and the International Liaison Committee on Resuscitation today recommends only to treat fever and keep body temperature below 37.5 °C (weak recommendation, low-certainty evidence). Here we describe the evolution of temperature management for patients with cardiac arrest during the past 20 years and how the accrued evidence has influenced not only the recommendations but also the guideline process. We also discuss possible paths forward in this field, bringing up both whether fever management is at all beneficial for patients with cardiac arrest and which knowledge gaps future clinical trials in temperature management should address.</p>}},
author = {{Nielsen, Niklas and Friberg, Hans}},
issn = {{1535-4970}},
keywords = {{cardiac arrest; functional outcome; heart arrest; hypothermia; targeted temperature management}},
language = {{eng}},
number = {{12}},
pages = {{1558--1564}},
publisher = {{American Thoracic Society}},
series = {{American Journal of Respiratory and Critical Care Medicine}},
title = {{Changes in Practice of Controlled Hypothermia after Cardiac Arrest in the Past 20 Years : A Critical Care Perspective}},
url = {{http://dx.doi.org/10.1164/rccm.202211-2142CP}},
doi = {{10.1164/rccm.202211-2142CP}},
volume = {{207}},
year = {{2023}},
}