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Mortality and cancer incidence among secondary lead smelter workers

Gerhardsson, L LU ; Hagmar, L LU ; Rylander, L LU and Skerfving, S LU (1995) In Occupational and environmental medicine 52(10). p.72-667
Abstract

OBJECTIVES: To examine the mortality pattern and the cancer incidence in a cohort of long term smelter workers exposed to lead.

METHODS: The cohort consists of 664 male lead battery workers, employed for at least three months in 1942-87. From 1969 the values of all blood lead samples repeatedly obtained from these workers every two to three months, have been collected in a database. The expected mortality and morbidity 1969-89 was estimated from the county rates, specified for cause, sex, five-year age groups, and calendar year. Individual exposure matrices have been calculated and used for dose-response analyses.

RESULTS: The total cohort showed an increased overall mortality (standardised mortality ratio (SMR) 1.44; 95%... (More)

OBJECTIVES: To examine the mortality pattern and the cancer incidence in a cohort of long term smelter workers exposed to lead.

METHODS: The cohort consists of 664 male lead battery workers, employed for at least three months in 1942-87. From 1969 the values of all blood lead samples repeatedly obtained from these workers every two to three months, have been collected in a database. The expected mortality and morbidity 1969-89 was estimated from the county rates, specified for cause, sex, five-year age groups, and calendar year. Individual exposure matrices have been calculated and used for dose-response analyses.

RESULTS: The total cohort showed an increased overall mortality (standardised mortality ratio (SMR) 1.44; 95% confidence interval (95% CI) 1.16-1.79), an increased mortality from ischaemic heart diseases (SMR 1.72; 95% CI 1.20-2.42) and all malignant neoplasms (SMR 1.65; 95% CI 1.09-2.44). These risk estimates were unaffected or slightly decreased when applying a latency period of 15 years, and no dose-response pattern was shown. The non-significantly raised cancer incidence in the gastrointestinal tract (11 malignancies) in the total cohort, increased to a barely significant level in the quartile with the highest cumulative lead exposure (standardised incidence ratio (SIR) 2.34, 95% CI 1.07-4.45). No clear dose response pattern was evident when further subdividing the data into those first employed up to 1969 v those first employed after 1969 when the blood lead monitoring programme started. The risk estimate for malignancies in the gastrointestinal tract was not related to latency time. The cancer incidence was not increased at other sites.

CONCLUSIONS: A slightly increased incidence of gastrointestinal cancers was found in workers exposed to lead and employed before 1970. The lead cohort also showed an increased mortality from ischaemic heart diseases. These risk estimates did not show a dose-response pattern and were not associated with latency time. The results must also be interpreted with caution because of limited numbers, and lack of dietary and smoking data.

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author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adult, Aged, Cardiovascular Diseases/mortality, Cause of Death, Gastrointestinal Neoplasms/epidemiology, Humans, Lead/blood, Male, Metallurgy, Middle Aged, Mortality, Myocardial Ischemia/mortality, Neoplasms/epidemiology, Occupational Exposure/analysis
in
Occupational and environmental medicine
volume
52
issue
10
pages
6 pages
publisher
BMJ Publishing Group
external identifiers
  • scopus:0028876980
ISSN
1351-0711
DOI
10.1136/oem.52.10.667
language
English
LU publication?
no
id
fa7552a5-f134-4034-bfba-167606c99b40
alternative location
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1128332/
date added to LUP
2018-08-27 13:53:04
date last changed
2018-09-02 04:48:12
@article{fa7552a5-f134-4034-bfba-167606c99b40,
  abstract     = {<p>OBJECTIVES: To examine the mortality pattern and the cancer incidence in a cohort of long term smelter workers exposed to lead.</p><p>METHODS: The cohort consists of 664 male lead battery workers, employed for at least three months in 1942-87. From 1969 the values of all blood lead samples repeatedly obtained from these workers every two to three months, have been collected in a database. The expected mortality and morbidity 1969-89 was estimated from the county rates, specified for cause, sex, five-year age groups, and calendar year. Individual exposure matrices have been calculated and used for dose-response analyses.</p><p>RESULTS: The total cohort showed an increased overall mortality (standardised mortality ratio (SMR) 1.44; 95% confidence interval (95% CI) 1.16-1.79), an increased mortality from ischaemic heart diseases (SMR 1.72; 95% CI 1.20-2.42) and all malignant neoplasms (SMR 1.65; 95% CI 1.09-2.44). These risk estimates were unaffected or slightly decreased when applying a latency period of 15 years, and no dose-response pattern was shown. The non-significantly raised cancer incidence in the gastrointestinal tract (11 malignancies) in the total cohort, increased to a barely significant level in the quartile with the highest cumulative lead exposure (standardised incidence ratio (SIR) 2.34, 95% CI 1.07-4.45). No clear dose response pattern was evident when further subdividing the data into those first employed up to 1969 v those first employed after 1969 when the blood lead monitoring programme started. The risk estimate for malignancies in the gastrointestinal tract was not related to latency time. The cancer incidence was not increased at other sites.</p><p>CONCLUSIONS: A slightly increased incidence of gastrointestinal cancers was found in workers exposed to lead and employed before 1970. The lead cohort also showed an increased mortality from ischaemic heart diseases. These risk estimates did not show a dose-response pattern and were not associated with latency time. The results must also be interpreted with caution because of limited numbers, and lack of dietary and smoking data.</p>},
  author       = {Gerhardsson, L and Hagmar, L and Rylander, L and Skerfving, S},
  issn         = {1351-0711},
  keyword      = {Adult,Aged,Cardiovascular Diseases/mortality,Cause of Death,Gastrointestinal Neoplasms/epidemiology,Humans,Lead/blood,Male,Metallurgy,Middle Aged,Mortality,Myocardial Ischemia/mortality,Neoplasms/epidemiology,Occupational Exposure/analysis},
  language     = {eng},
  number       = {10},
  pages        = {72--667},
  publisher    = {BMJ Publishing Group},
  series       = {Occupational and environmental medicine},
  title        = {Mortality and cancer incidence among secondary lead smelter workers},
  url          = {http://dx.doi.org/10.1136/oem.52.10.667},
  volume       = {52},
  year         = {1995},
}