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Preliminary studies on the role of ten-a during CNS and eye development of Drosophila.

Ngernsiri, Lertluk ; Fascetti, Nora LU ; Wisorum, Wijit and Baumgartner, Stefan LU orcid (2005) In ScienceAsia 31. p.5-11
Abstract
ten-a is one of the two Drosophila genes whose products belong to the Ten M protein family. The
Ten-a protein is a type II transmembrane protein. This protein was found to be mainly expressed in the CNS
of the embryo and in the compound eye of the pupa. No report about the function of ten-a has been
published to date. Here, we showed, in a preliminary report, that ten-a has a function in the development of
the CNS and in the compound eye. To study the function of ten-a during CNS development, doublestranded RNA interference (dsRNAi) experiments were performed. We found that embryos without Ten-a
protein have defects in the commissures, suggesting that ten-a is likely to be involved in commissure
formation.... (More)
ten-a is one of the two Drosophila genes whose products belong to the Ten M protein family. The
Ten-a protein is a type II transmembrane protein. This protein was found to be mainly expressed in the CNS
of the embryo and in the compound eye of the pupa. No report about the function of ten-a has been
published to date. Here, we showed, in a preliminary report, that ten-a has a function in the development of
the CNS and in the compound eye. To study the function of ten-a during CNS development, doublestranded RNA interference (dsRNAi) experiments were performed. We found that embryos without Ten-a
protein have defects in the commissures, suggesting that ten-a is likely to be involved in commissure
formation. Furthermore, to study the function of ten-a in the eye, the Gal4/UAS system was used to
overexpress ten-a at different stages of eye development. We found that extra amounts of Ten-a can interfere
with the development of the eye. Flies overexpressing ten-a showed eye defects such as small and rough eyes,
and black ommatidia. The results indicated that ten-a may be a novel gene involved in eye morphogenesis (Less)
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type
Contribution to journal
publication status
published
subject
in
ScienceAsia
volume
31
pages
5 - 11
publisher
Thailands Natl Science & Technology Development Agency
external identifiers
  • scopus:85040432006
ISSN
1513-1874
language
English
LU publication?
yes
id
fa99d1c1-1f25-4fa4-9183-325047c01efe
alternative location
http://www.scienceasia.org/2005.31.n1/v31_005_011.pdf
date added to LUP
2022-07-26 15:12:57
date last changed
2023-04-13 04:08:09
@article{fa99d1c1-1f25-4fa4-9183-325047c01efe,
  abstract     = {{ten-a is one of the two Drosophila genes whose products belong to the Ten M protein family. The<br/>Ten-a protein is a type II transmembrane protein. This protein was found to be mainly expressed in the CNS<br/>of the embryo and in the compound eye of the pupa. No report about the function of ten-a has been<br/>published to date. Here, we showed, in a preliminary report, that ten-a has a function in the development of<br/>the CNS and in the compound eye. To study the function of ten-a during CNS development, doublestranded RNA interference (dsRNAi) experiments were performed. We found that embryos without Ten-a<br/>protein have defects in the commissures, suggesting that ten-a is likely to be involved in commissure<br/>formation. Furthermore, to study the function of ten-a in the eye, the Gal4/UAS system was used to<br/>overexpress ten-a at different stages of eye development. We found that extra amounts of Ten-a can interfere<br/>with the development of the eye. Flies overexpressing ten-a showed eye defects such as small and rough eyes,<br/>and black ommatidia. The results indicated that ten-a may be a novel gene involved in eye morphogenesis}},
  author       = {{Ngernsiri, Lertluk and Fascetti, Nora and Wisorum, Wijit and Baumgartner, Stefan}},
  issn         = {{1513-1874}},
  language     = {{eng}},
  pages        = {{5--11}},
  publisher    = {{Thailands Natl Science & Technology Development Agency}},
  series       = {{ScienceAsia}},
  title        = {{Preliminary studies on the role of ten-a during CNS and eye development of Drosophila.}},
  url          = {{http://www.scienceasia.org/2005.31.n1/v31_005_011.pdf}},
  volume       = {{31}},
  year         = {{2005}},
}