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Identifying predictors of early growth response and adverse radiation effects of vestibular schwannomas to radiosurgery

Larjani, Soroush ; Monsalves, Eric ; Pebdani, Houman LU ; Krischek, Boris ; Gentili, Fred and Zadeh, Gelareh (2014) In PLoS ONE 9(10). p.1-7
Abstract
Methods
A retrospective review of a prospectively maintained database of all VS patients treated with 12Gy prescription dose between September 2005 and June 2011 at our institution using the Leksell Model 4C Gamma Knife Unit was conducted. Patients who had a minimum of 12-months clinical and radiological assessment before and after radiosurgery were included in this study. Tumor growth rates were calculated using specific growth rate (SGR). Tumor volumes were measured on FIESTA-MRI scans using ITK-SNAP v2.2.

Results
Following radiosurgery, twenty-seven (42.9%) patients showed a significant decrease in volume after one year, twenty-nine (46.0%) stabilized, and seven (11.1%) continued to grow. There was no correlation... (More)
Methods
A retrospective review of a prospectively maintained database of all VS patients treated with 12Gy prescription dose between September 2005 and June 2011 at our institution using the Leksell Model 4C Gamma Knife Unit was conducted. Patients who had a minimum of 12-months clinical and radiological assessment before and after radiosurgery were included in this study. Tumor growth rates were calculated using specific growth rate (SGR). Tumor volumes were measured on FIESTA-MRI scans using ITK-SNAP v2.2.

Results
Following radiosurgery, twenty-seven (42.9%) patients showed a significant decrease in volume after one year, twenty-nine (46.0%) stabilized, and seven (11.1%) continued to grow. There was no correlation between VS pre-treatment SGRs with post-treatment SGRs (p = 0.34), and incidence of adverse radiation effects (ARE). The reduction in tumors' SGRs after radiosurgery was proportional to pre-treatment SGRs, although this correlation was not statistically significant (p = 0.19). Analysis of risk factors revealed a positive correlation between post-treatment SGRs and incidence of non-auditory complications, most of which were attributed to ARE (p = 0.047).

Conclusion
Pre-treatment growth rate of VS does not predict tumor response to radiosurgery or incidence of ARE. VS with higher SGRs post-radiosurgery are more likely to experience ARE. (Less)
Please use this url to cite or link to this publication:
author
; ; ; ; and
contributor
Cusimano, Michael ; Laperriere, Normand and Hayhurst, Caroline
publishing date
type
Contribution to journal
publication status
published
keywords
schwannoma, Vestibular schwannoma, Gamma knife, Radiosurgery, Skull base tumors
in
PLoS ONE
volume
9
issue
10
article number
e110823
pages
1 - 7
publisher
Public Library of Science (PLoS)
external identifiers
  • scopus:84908458513
ISSN
1932-6203
DOI
10.1371/journal.pone.0110823
language
English
LU publication?
no
id
faaa2d92-8655-4ead-a690-acec9902064c
alternative location
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0110823
date added to LUP
2022-04-09 23:56:54
date last changed
2022-04-11 08:07:49
@article{faaa2d92-8655-4ead-a690-acec9902064c,
  abstract     = {{Methods<br/>A retrospective review of a prospectively maintained database of all VS patients treated with 12Gy prescription dose between September 2005 and June 2011 at our institution using the Leksell Model 4C Gamma Knife Unit was conducted. Patients who had a minimum of 12-months clinical and radiological assessment before and after radiosurgery were included in this study. Tumor growth rates were calculated using specific growth rate (SGR). Tumor volumes were measured on FIESTA-MRI scans using ITK-SNAP v2.2.<br/><br/>Results<br/>Following radiosurgery, twenty-seven (42.9%) patients showed a significant decrease in volume after one year, twenty-nine (46.0%) stabilized, and seven (11.1%) continued to grow. There was no correlation between VS pre-treatment SGRs with post-treatment SGRs (p = 0.34), and incidence of adverse radiation effects (ARE). The reduction in tumors' SGRs after radiosurgery was proportional to pre-treatment SGRs, although this correlation was not statistically significant (p = 0.19). Analysis of risk factors revealed a positive correlation between post-treatment SGRs and incidence of non-auditory complications, most of which were attributed to ARE (p = 0.047).<br/><br/>Conclusion<br/>Pre-treatment growth rate of VS does not predict tumor response to radiosurgery or incidence of ARE. VS with higher SGRs post-radiosurgery are more likely to experience ARE.}},
  author       = {{Larjani, Soroush and Monsalves, Eric and Pebdani, Houman and Krischek, Boris and Gentili, Fred and Zadeh, Gelareh}},
  issn         = {{1932-6203}},
  keywords     = {{schwannoma; Vestibular schwannoma; Gamma knife; Radiosurgery; Skull base tumors}},
  language     = {{eng}},
  month        = {{10}},
  number       = {{10}},
  pages        = {{1--7}},
  publisher    = {{Public Library of Science (PLoS)}},
  series       = {{PLoS ONE}},
  title        = {{Identifying predictors of early growth response and adverse radiation effects of vestibular schwannomas to radiosurgery}},
  url          = {{http://dx.doi.org/10.1371/journal.pone.0110823}},
  doi          = {{10.1371/journal.pone.0110823}},
  volume       = {{9}},
  year         = {{2014}},
}