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Trends in Antimicrobial Drug Resistance of Streptococcus pneumoniae Isolates at Jordan University Hospital (2000–2018)

Sallam, Malik LU ; Abbadi, Jumana; Natsheh, Anas; Ababneh, Nidaa; Mahafzah, Azmi and Özkaya Sahin, Gülsen LU (2019) In Antibiotics (Basel) 8(2).
Abstract
Antimicrobial drug resistance (AMR) in pneumococci complicates the treatment of serious pneumococcal infections. Country-specific AMR patterns can help to establish guidelines for empiric therapy. The aim of the current study was to analyze the distribution of AMR among Streptococcus pneumoniae isolates at Jordan University Hospital (JUH) during 2000–2018. Paper-based and electronic clinical data registry records from 2000 to 2018 were retrospectively analyzed to study the AMR among pneumococcal isolates at JUH. Temporal trend analysis was done using two-tailed linear-by-linear test for association. The total number of unique pneumococcal isolates that were identified was 556, of which 544 isolates had antimicrobial susceptibility testing... (More)
Antimicrobial drug resistance (AMR) in pneumococci complicates the treatment of serious pneumococcal infections. Country-specific AMR patterns can help to establish guidelines for empiric therapy. The aim of the current study was to analyze the distribution of AMR among Streptococcus pneumoniae isolates at Jordan University Hospital (JUH) during 2000–2018. Paper-based and electronic clinical data registry records from 2000 to 2018 were retrospectively analyzed to study the AMR among pneumococcal isolates at JUH. Temporal trend analysis was done using two-tailed linear-by-linear test for association. The total number of unique pneumococcal isolates that were identified was 556, of which 544 isolates had antimicrobial susceptibility testing results. The most frequent specimens were eye (n = 117, 21.0%), bloodstream (n = 93, 16.7%) and sputum (n = 81, 14.6%). Invasive infections represented 23.6% of all unique isolates. The overall susceptibility of S. pneumoniae isolates during the study period to different antimicrobials was: 100% to vancomycin, 97.7% to ceftriaxone, 97.1% to cefotaxime, 94.9% to chloramphenicol, 89.7% to penicillin, 83.8% to levofloxacin, 67.7% to clindamycin and 52.1% to erythromycin. The prevalence of multi-drug resistance (MDR) was 8.6% (95% confidence interval: 6.4–11.5%). Trend analysis showed an increase in the prevalence of non-susceptibility to erythromycin, clindamycin and levofloxacin (p < 0.001). MDR prevalence increased from 1.6% in the first quarter to 14.6% in the fourth quarter (p < 0.001). The incidence of invasive infections declined over the study period (p < 0.001). The increase in the prevalence of AMR and MDR among pneumococcal isolates in Jordan demands judicious use of antimicrobials and regular surveillance of resistance. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Streptococcus pneumoniae; meningitis; bacteremia; antibiotic; Middle East; Jordan; resistance; trend
in
Antibiotics (Basel)
volume
8
issue
2
pages
11 pages
publisher
Multidisciplinary Digital Publishing Institute (MDPI)
external identifiers
  • scopus:85066980244
ISSN
2079-6382
DOI
10.3390/antibiotics8020041
language
English
LU publication?
yes
id
faacb8e0-e1ee-4a12-bf70-9d48ce14c73a
date added to LUP
2019-04-16 20:30:53
date last changed
2019-07-16 04:07:11
@article{faacb8e0-e1ee-4a12-bf70-9d48ce14c73a,
  abstract     = {Antimicrobial drug resistance (AMR) in pneumococci complicates the treatment of serious pneumococcal infections. Country-specific AMR patterns can help to establish guidelines for empiric therapy. The aim of the current study was to analyze the distribution of AMR among Streptococcus pneumoniae isolates at Jordan University Hospital (JUH) during 2000–2018. Paper-based and electronic clinical data registry records from 2000 to 2018 were retrospectively analyzed to study the AMR among pneumococcal isolates at JUH. Temporal trend analysis was done using two-tailed linear-by-linear test for association. The total number of unique pneumococcal isolates that were identified was 556, of which 544 isolates had antimicrobial susceptibility testing results. The most frequent specimens were eye (n = 117, 21.0%), bloodstream (n = 93, 16.7%) and sputum (n = 81, 14.6%). Invasive infections represented 23.6% of all unique isolates. The overall susceptibility of S. pneumoniae isolates during the study period to different antimicrobials was: 100% to vancomycin, 97.7% to ceftriaxone, 97.1% to cefotaxime, 94.9% to chloramphenicol, 89.7% to penicillin, 83.8% to levofloxacin, 67.7% to clindamycin and 52.1% to erythromycin. The prevalence of multi-drug resistance (MDR) was 8.6% (95% confidence interval: 6.4–11.5%). Trend analysis showed an increase in the prevalence of non-susceptibility to erythromycin, clindamycin and levofloxacin (p &lt; 0.001). MDR prevalence increased from 1.6% in the first quarter to 14.6% in the fourth quarter (p &lt; 0.001). The incidence of invasive infections declined over the study period (p &lt; 0.001). The increase in the prevalence of AMR and MDR among pneumococcal isolates in Jordan demands judicious use of antimicrobials and regular surveillance of resistance.},
  articleno    = {41},
  author       = {Sallam, Malik and Abbadi, Jumana and Natsheh, Anas and Ababneh, Nidaa and Mahafzah, Azmi and Özkaya Sahin, Gülsen},
  issn         = {2079-6382},
  keyword      = {Streptococcus pneumoniae; meningitis; bacteremia; antibiotic; Middle East; Jordan; resistance; trend},
  language     = {eng},
  month        = {04},
  number       = {2},
  pages        = {11},
  publisher    = {Multidisciplinary Digital Publishing Institute (MDPI)},
  series       = {Antibiotics (Basel)},
  title        = {Trends in Antimicrobial Drug Resistance of Streptococcus pneumoniae Isolates at Jordan University Hospital (2000–2018)},
  url          = {http://dx.doi.org/10.3390/antibiotics8020041},
  volume       = {8},
  year         = {2019},
}