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Automatic correction for phase shifts, frequency shifts, and lineshape distortions across a series of single resonance lines in large spectral data sets

Witjes, H; Melssen, W J; in 't Zandt, H J LU ; van der Graaf, Marinette; Heerschap, Arend and Buydens, L M (2000) In Journal of Magnetic Resonance 144(1). p.35-44
Abstract

A new model-free method is presented that automatically corrects for phase shifts, frequency shifts, and additional lineshape distortions of one single resonance peak across a series of in vivo NMR spectra. All separate phase and frequency variations are quickly and directly derived from the common lineshape in the data set using principal component analysis and linear regression. First, the new approach is evaluated on simulated data in order to quantitatively assess the phase and frequency shifts which can be removed by the proposed correction procedure. Subsequently, the value of the method is demonstrated on in vivo (31)P NMR spectra from skeletal muscle of the hind leg of the mouse focusing on the phosphocreatine resonance which is... (More)

A new model-free method is presented that automatically corrects for phase shifts, frequency shifts, and additional lineshape distortions of one single resonance peak across a series of in vivo NMR spectra. All separate phase and frequency variations are quickly and directly derived from the common lineshape in the data set using principal component analysis and linear regression. First, the new approach is evaluated on simulated data in order to quantitatively assess the phase and frequency shifts which can be removed by the proposed correction procedure. Subsequently, the value of the method is demonstrated on in vivo (31)P NMR spectra from skeletal muscle of the hind leg of the mouse focusing on the phosphocreatine resonance which is distorted by the experimental procedure. Phase shifts, frequency shifts, and lineshape distortions with respect to the common lineshape in the spectral data set could successfully be removed.

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Please use this url to cite or link to this publication:
author
publishing date
type
Contribution to journal
publication status
published
keywords
Animals, Computer Simulation, Hindlimb, Linear Models, Magnetic Resonance Spectroscopy, Mice, Muscle, Skeletal, Phosphocreatine, Journal Article
in
Journal of Magnetic Resonance
volume
144
issue
1
pages
10 pages
publisher
Elsevier
external identifiers
  • scopus:0034184851
ISSN
1090-7807
DOI
10.1006/jmre.2000.2021
language
English
LU publication?
no
id
fac504be-1dc4-4f70-bb5e-6b607208f0ea
date added to LUP
2017-03-06 16:54:44
date last changed
2017-09-17 09:42:37
@article{fac504be-1dc4-4f70-bb5e-6b607208f0ea,
  abstract     = {<p>A new model-free method is presented that automatically corrects for phase shifts, frequency shifts, and additional lineshape distortions of one single resonance peak across a series of in vivo NMR spectra. All separate phase and frequency variations are quickly and directly derived from the common lineshape in the data set using principal component analysis and linear regression. First, the new approach is evaluated on simulated data in order to quantitatively assess the phase and frequency shifts which can be removed by the proposed correction procedure. Subsequently, the value of the method is demonstrated on in vivo (31)P NMR spectra from skeletal muscle of the hind leg of the mouse focusing on the phosphocreatine resonance which is distorted by the experimental procedure. Phase shifts, frequency shifts, and lineshape distortions with respect to the common lineshape in the spectral data set could successfully be removed.</p>},
  author       = {Witjes, H and Melssen, W J and in 't Zandt, H J and van der Graaf, Marinette and Heerschap, Arend and Buydens, L M},
  issn         = {1090-7807},
  keyword      = {Animals,Computer Simulation,Hindlimb,Linear Models,Magnetic Resonance Spectroscopy,Mice,Muscle, Skeletal,Phosphocreatine,Journal Article},
  language     = {eng},
  number       = {1},
  pages        = {35--44},
  publisher    = {Elsevier},
  series       = {Journal of Magnetic Resonance},
  title        = {Automatic correction for phase shifts, frequency shifts, and lineshape distortions across a series of single resonance lines in large spectral data sets},
  url          = {http://dx.doi.org/10.1006/jmre.2000.2021},
  volume       = {144},
  year         = {2000},
}