Advanced

The inheritance of hip osteoarthritis in Iceland

Ingvarsson, Thorvaldur LU ; Stefánsson, Stefán Einar; Hallgrímsdttir, Ingileif B.; Frigge, Michael L.; Jnsson, Halldr; Gulcher, Jeff; Jnsson, Helgi; Ragnarsson, Jn Ingvar; Stefan Lohmander, L. LU and Stefánsson, Kári (2000) In Arthritis and Rheumatism 43(12). p.2785-2792
Abstract

Objective. To assess, in a population-wide study in Iceland, the genetic contribution to hip osteoarthritis (OA) leading to total hip replacement (THR). Methods. Information from 2 population-based databases in Iceland was combined: a national registry of all THRs performed between 1972 and 1996, and a genealogy database of all available Icelandic genealogy records for the last 11 centuries. A genetic contribution to THR for OA was assessed by 1) identifying familial clusters of OA patients with THR, 2) applying the minimum founder test (MFT) to estimate the minimum number of ancestors ('founders') that would account for the genealogy of all 2,713 patients with THR for OA, compared with the average number of founders for control lists,... (More)

Objective. To assess, in a population-wide study in Iceland, the genetic contribution to hip osteoarthritis (OA) leading to total hip replacement (THR). Methods. Information from 2 population-based databases in Iceland was combined: a national registry of all THRs performed between 1972 and 1996, and a genealogy database of all available Icelandic genealogy records for the last 11 centuries. A genetic contribution to THR for OA was assessed by 1) identifying familial clusters of OA patients with THR, 2) applying the minimum founder test (MFT) to estimate the minimum number of ancestors ('founders') that would account for the genealogy of all 2,713 patients with THR for OA, compared with the average number of founders for control lists, 3) calculating an average pairwise kinship coefficient (KC) for the patient list and control lists, and 4) estimating the relative risk (RR) for THR among relatives of OA patients who have undergone the procedure. One thousand matched control lists, each the same size as the patient list, were created using the genealogy database. Results. A large number of familial clusters of patients with THR for OA were identified. The MFT showed that OA patients descended from fewer founders than did subjects in the control groups (P <0.001). The average pairwise KC among patients with OA was greater than in the control population (P <0.001). The RR for THR among siblings of OA patients was 3.05 (95% confidence interval 2.52-3.10). Conclusion. This population-based study shows that icelandic patients with hip replacement for OA are significantly more related to each other than are matched controls drawn from the Icelandic population. These findings support a significant genetic contribution to a common form of OA and encourage the search for genes conferring an increased susceptibility to OA.

(Less)
Please use this url to cite or link to this publication:
author
publishing date
type
Contribution to journal
publication status
published
in
Arthritis and Rheumatism
volume
43
issue
12
pages
8 pages
publisher
John Wiley & Sons
external identifiers
  • scopus:0034541487
ISSN
0004-3591
DOI
10.1002/1529-0131(200012)43:12<2785::AID-ANR19>3.0.CO;2-I
language
English
LU publication?
no
id
fad7244a-48f3-466f-b4fd-0c45a1fd0f70
date added to LUP
2016-05-05 11:32:20
date last changed
2017-01-01 08:25:18
@article{fad7244a-48f3-466f-b4fd-0c45a1fd0f70,
  abstract     = {<p>Objective. To assess, in a population-wide study in Iceland, the genetic contribution to hip osteoarthritis (OA) leading to total hip replacement (THR). Methods. Information from 2 population-based databases in Iceland was combined: a national registry of all THRs performed between 1972 and 1996, and a genealogy database of all available Icelandic genealogy records for the last 11 centuries. A genetic contribution to THR for OA was assessed by 1) identifying familial clusters of OA patients with THR, 2) applying the minimum founder test (MFT) to estimate the minimum number of ancestors ('founders') that would account for the genealogy of all 2,713 patients with THR for OA, compared with the average number of founders for control lists, 3) calculating an average pairwise kinship coefficient (KC) for the patient list and control lists, and 4) estimating the relative risk (RR) for THR among relatives of OA patients who have undergone the procedure. One thousand matched control lists, each the same size as the patient list, were created using the genealogy database. Results. A large number of familial clusters of patients with THR for OA were identified. The MFT showed that OA patients descended from fewer founders than did subjects in the control groups (P &lt;0.001). The average pairwise KC among patients with OA was greater than in the control population (P &lt;0.001). The RR for THR among siblings of OA patients was 3.05 (95% confidence interval 2.52-3.10). Conclusion. This population-based study shows that icelandic patients with hip replacement for OA are significantly more related to each other than are matched controls drawn from the Icelandic population. These findings support a significant genetic contribution to a common form of OA and encourage the search for genes conferring an increased susceptibility to OA.</p>},
  author       = {Ingvarsson, Thorvaldur and Stefánsson, Stefán Einar and Hallgrímsdttir, Ingileif B. and Frigge, Michael L. and Jnsson, Halldr and Gulcher, Jeff and Jnsson, Helgi and Ragnarsson, Jn Ingvar and Stefan Lohmander, L. and Stefánsson, Kári},
  issn         = {0004-3591},
  language     = {eng},
  number       = {12},
  pages        = {2785--2792},
  publisher    = {John Wiley & Sons},
  series       = {Arthritis and Rheumatism},
  title        = {The inheritance of hip osteoarthritis in Iceland},
  url          = {http://dx.doi.org/10.1002/1529-0131(200012)43:12<2785::AID-ANR19>3.0.CO;2-I},
  volume       = {43},
  year         = {2000},
}