Intrathecal release of nitric oxide in Alzheimer's disease and vascular dementia
(2000) In Dementia and Geriatric Cognitive Disorders 11(6). p.6-322- Abstract
A growing body of evidence points out the potential role of inflammatory mechanisms in the pathophysiology of brain damage in dementia. We have recently demonstrated that patients with Alzheimer's disease (AD) and vascular dementia (VaD) display an intrathecal production of proinflammatory cytokines. TNF-alpha, one of these cytokines, leads to the production of nitric oxide (NO), a potent inflammatory mediator, by induction of inducible NO synthase. The aim of the present study was to investigate the intrathecal levels of nitrate, one of the main metabolites of NO, and to relate its levels to the degree of intellectual impairment, in patients with AD and VaD. Twenty patients with early AD and 26 patients with VaD were analyzed with... (More)
A growing body of evidence points out the potential role of inflammatory mechanisms in the pathophysiology of brain damage in dementia. We have recently demonstrated that patients with Alzheimer's disease (AD) and vascular dementia (VaD) display an intrathecal production of proinflammatory cytokines. TNF-alpha, one of these cytokines, leads to the production of nitric oxide (NO), a potent inflammatory mediator, by induction of inducible NO synthase. The aim of the present study was to investigate the intrathecal levels of nitrate, one of the main metabolites of NO, and to relate its levels to the degree of intellectual impairment, in patients with AD and VaD. Twenty patients with early AD and 26 patients with VaD were analyzed with respect to cerebrospinal fluid levels of nitrate by gas chromatography/mass spectrometry. Interestingly, in patients with AD but not VaD, the intrathecal levels of nitrate were significantly and inversely correlated (r = -0.68, p = 0.002) to the degree of intellectual impairment. Our study demonstrates an inverse correlation between the intrathecal levels of nitrate and the degree of cognitive impairment in patients with AD, suggesting a neuroprotective effect of NO in AD.
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- author
- Tarkowski, E ; Ringqvist, Å LU ; Blennow, K LU ; Wallin, A and Wennmalm, Å
- publishing date
- 2000
- type
- Contribution to journal
- publication status
- published
- keywords
- Aged, Alzheimer Disease/cerebrospinal fluid, Dementia, Vascular/cerebrospinal fluid, Female, Humans, Indicators and Reagents, Male, Middle Aged, Nitrates/cerebrospinal fluid, Nitric Oxide/cerebrospinal fluid, Spinal Cord/metabolism
- in
- Dementia and Geriatric Cognitive Disorders
- volume
- 11
- issue
- 6
- pages
- 6 - 322
- publisher
- Karger
- external identifiers
-
- scopus:0033754462
- pmid:11044777
- ISSN
- 1420-8008
- DOI
- 10.1159/000017261
- language
- English
- LU publication?
- no
- additional info
- Copyright 2000 S. Karger AG, Basel
- id
- fae5f2a1-1417-4e60-9fa3-9e0c48d8aa52
- date added to LUP
- 2022-05-09 14:46:51
- date last changed
- 2024-03-06 07:00:29
@article{fae5f2a1-1417-4e60-9fa3-9e0c48d8aa52,
abstract = {{<p>A growing body of evidence points out the potential role of inflammatory mechanisms in the pathophysiology of brain damage in dementia. We have recently demonstrated that patients with Alzheimer's disease (AD) and vascular dementia (VaD) display an intrathecal production of proinflammatory cytokines. TNF-alpha, one of these cytokines, leads to the production of nitric oxide (NO), a potent inflammatory mediator, by induction of inducible NO synthase. The aim of the present study was to investigate the intrathecal levels of nitrate, one of the main metabolites of NO, and to relate its levels to the degree of intellectual impairment, in patients with AD and VaD. Twenty patients with early AD and 26 patients with VaD were analyzed with respect to cerebrospinal fluid levels of nitrate by gas chromatography/mass spectrometry. Interestingly, in patients with AD but not VaD, the intrathecal levels of nitrate were significantly and inversely correlated (r = -0.68, p = 0.002) to the degree of intellectual impairment. Our study demonstrates an inverse correlation between the intrathecal levels of nitrate and the degree of cognitive impairment in patients with AD, suggesting a neuroprotective effect of NO in AD.</p>}},
author = {{Tarkowski, E and Ringqvist, Å and Blennow, K and Wallin, A and Wennmalm, Å}},
issn = {{1420-8008}},
keywords = {{Aged; Alzheimer Disease/cerebrospinal fluid; Dementia, Vascular/cerebrospinal fluid; Female; Humans; Indicators and Reagents; Male; Middle Aged; Nitrates/cerebrospinal fluid; Nitric Oxide/cerebrospinal fluid; Spinal Cord/metabolism}},
language = {{eng}},
number = {{6}},
pages = {{6--322}},
publisher = {{Karger}},
series = {{Dementia and Geriatric Cognitive Disorders}},
title = {{Intrathecal release of nitric oxide in Alzheimer's disease and vascular dementia}},
url = {{http://dx.doi.org/10.1159/000017261}},
doi = {{10.1159/000017261}},
volume = {{11}},
year = {{2000}},
}