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Immune Thrombocytopenia

Li, Qizhao ; Rebetz, Johan LU orcid ; Provan, Drew ; Porcelijn, Leendert L. ; Kapur, Rick ; Hofstede-Van Egmond, Suzanne ; Semple, Elisabeth ; Guo, Li ; Xu, Shuqian and Semple, John W. LU (2024) 2. p.1105-1112
Abstract

Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder, and ITP presents as either primary or, during the course of the disease, secondary, where approximately 20% of the cases are secondary to other diseases such as systemic autoimmune disease. The management goal of ITP is to treat or prevent severe bleeding, not to normalize the platelet count. ITP is thought to be an autoimmune syndrome triggered by a combination of multiple factors including immune-tolerance dysregulation, environmental insults (e.g., infections), and genetic susceptibility. Autoantibodies can be detected in approximately 60 to 80% of patients with ITP. Myeloid-derived suppressor cells are a heterogeneous population of myeloid progenitor cells derived... (More)

Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder, and ITP presents as either primary or, during the course of the disease, secondary, where approximately 20% of the cases are secondary to other diseases such as systemic autoimmune disease. The management goal of ITP is to treat or prevent severe bleeding, not to normalize the platelet count. ITP is thought to be an autoimmune syndrome triggered by a combination of multiple factors including immune-tolerance dysregulation, environmental insults (e.g., infections), and genetic susceptibility. Autoantibodies can be detected in approximately 60 to 80% of patients with ITP. Myeloid-derived suppressor cells are a heterogeneous population of myeloid progenitor cells derived from the bone marrow, secrete a multitude of immunoregulatory cytokines, can significantly reduce macrophages and DCs, decrease secretion of several proinflammatory cytokines, and reduce Th1 cell production.

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Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Autoantibodies, Autoimmune syndrome, Genetic susceptibility, Immune thrombocytopenia, Immunoregulatory cytokines, Myeloid-derived suppressor cells, Platelet count, Proinflammatory cytokines, Systemic autoimmune disease
host publication
Manual of Molecular and Clinical Laboratory Immunology, 9th Edition : Volume 1-2 - Volume 1-2
volume
2
pages
8 pages
publisher
Wiley
external identifiers
  • scopus:85213524709
ISBN
9781683674023
9781683673996
DOI
10.1002/9781683674023.ch100
language
English
LU publication?
yes
id
fae8808a-97ff-4164-bc0b-98c8644d072f
date added to LUP
2025-02-26 10:21:46
date last changed
2025-06-18 19:15:13
@inbook{fae8808a-97ff-4164-bc0b-98c8644d072f,
  abstract     = {{<p>Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder, and ITP presents as either primary or, during the course of the disease, secondary, where approximately 20% of the cases are secondary to other diseases such as systemic autoimmune disease. The management goal of ITP is to treat or prevent severe bleeding, not to normalize the platelet count. ITP is thought to be an autoimmune syndrome triggered by a combination of multiple factors including immune-tolerance dysregulation, environmental insults (e.g., infections), and genetic susceptibility. Autoantibodies can be detected in approximately 60 to 80% of patients with ITP. Myeloid-derived suppressor cells are a heterogeneous population of myeloid progenitor cells derived from the bone marrow, secrete a multitude of immunoregulatory cytokines, can significantly reduce macrophages and DCs, decrease secretion of several proinflammatory cytokines, and reduce Th1 cell production.</p>}},
  author       = {{Li, Qizhao and Rebetz, Johan and Provan, Drew and Porcelijn, Leendert L. and Kapur, Rick and Hofstede-Van Egmond, Suzanne and Semple, Elisabeth and Guo, Li and Xu, Shuqian and Semple, John W.}},
  booktitle    = {{Manual of Molecular and Clinical Laboratory Immunology, 9th Edition : Volume 1-2}},
  isbn         = {{9781683674023}},
  keywords     = {{Autoantibodies; Autoimmune syndrome; Genetic susceptibility; Immune thrombocytopenia; Immunoregulatory cytokines; Myeloid-derived suppressor cells; Platelet count; Proinflammatory cytokines; Systemic autoimmune disease}},
  language     = {{eng}},
  month        = {{01}},
  pages        = {{1105--1112}},
  publisher    = {{Wiley}},
  title        = {{Immune Thrombocytopenia}},
  url          = {{http://dx.doi.org/10.1002/9781683674023.ch100}},
  doi          = {{10.1002/9781683674023.ch100}},
  volume       = {{2}},
  year         = {{2024}},
}