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Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data

Shungin, Dmitry LU ; Haworth, Simon ; Divaris, Kimon ; Agler, Cary S. ; Kamatani, Yoichiro ; Keun Lee, Myoung ; Grinde, Kelsey ; Hindy, George LU ; Alaraudanjoki, Viivi and Pesonen, Paula , et al. (2019) In Nature Communications 10(1).
Abstract

Dental caries and periodontitis account for a vast burden of morbidity and healthcare spending, yet their genetic basis remains largely uncharacterized. Here, we identify self-reported dental disease proxies which have similar underlying genetic contributions to clinical disease measures and then combine these in a genome-wide association study meta-analysis, identifying 47 novel and conditionally-independent risk loci for dental caries. We show that the heritability of dental caries is enriched for conserved genomic regions and partially overlapping with a range of complex traits including smoking, education, personality traits and metabolic measures. Using cardio-metabolic traits as an example in Mendelian randomization analysis, we... (More)

Dental caries and periodontitis account for a vast burden of morbidity and healthcare spending, yet their genetic basis remains largely uncharacterized. Here, we identify self-reported dental disease proxies which have similar underlying genetic contributions to clinical disease measures and then combine these in a genome-wide association study meta-analysis, identifying 47 novel and conditionally-independent risk loci for dental caries. We show that the heritability of dental caries is enriched for conserved genomic regions and partially overlapping with a range of complex traits including smoking, education, personality traits and metabolic measures. Using cardio-metabolic traits as an example in Mendelian randomization analysis, we estimate causal relationships and provide evidence suggesting that the processes contributing to dental caries may have undesirable downstream effects on health.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nature Communications
volume
10
issue
1
article number
2773
publisher
Nature Publishing Group
external identifiers
  • pmid:31235808
  • scopus:85067889749
ISSN
2041-1723
DOI
10.1038/s41467-019-10630-1
language
English
LU publication?
yes
id
faec2925-abee-4bb5-bac4-9623c97f3fce
date added to LUP
2019-07-03 14:56:46
date last changed
2023-09-23 09:22:52
@article{faec2925-abee-4bb5-bac4-9623c97f3fce,
  abstract     = {{<p>Dental caries and periodontitis account for a vast burden of morbidity and healthcare spending, yet their genetic basis remains largely uncharacterized. Here, we identify self-reported dental disease proxies which have similar underlying genetic contributions to clinical disease measures and then combine these in a genome-wide association study meta-analysis, identifying 47 novel and conditionally-independent risk loci for dental caries. We show that the heritability of dental caries is enriched for conserved genomic regions and partially overlapping with a range of complex traits including smoking, education, personality traits and metabolic measures. Using cardio-metabolic traits as an example in Mendelian randomization analysis, we estimate causal relationships and provide evidence suggesting that the processes contributing to dental caries may have undesirable downstream effects on health.</p>}},
  author       = {{Shungin, Dmitry and Haworth, Simon and Divaris, Kimon and Agler, Cary S. and Kamatani, Yoichiro and Keun Lee, Myoung and Grinde, Kelsey and Hindy, George and Alaraudanjoki, Viivi and Pesonen, Paula and Teumer, Alexander and Holtfreter, Birte and Sakaue, Saori and Hirata, Jun and Yu, Yau Hua and Ridker, Paul M. and Giulianini, Franco and Chasman, Daniel I. and Magnusson, Patrik K.E. and Sudo, Takeaki and Okada, Yukinori and Völker, Uwe and Kocher, Thomas and Anttonen, Vuokko and Laitala, Marja Liisa and Orho-Melander, Marju and Sofer, Tamar and Shaffer, John R. and Vieira, Alexandre and Marazita, Mary L. and Kubo, Michiaki and Furuichi, Yasushi and North, Kari E. and Offenbacher, Steve and Ingelsson, Erik and Franks, Paul W. and Timpson, Nicholas J. and Johansson, Ingegerd}},
  issn         = {{2041-1723}},
  language     = {{eng}},
  month        = {{06}},
  number       = {{1}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Nature Communications}},
  title        = {{Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data}},
  url          = {{http://dx.doi.org/10.1038/s41467-019-10630-1}},
  doi          = {{10.1038/s41467-019-10630-1}},
  volume       = {{10}},
  year         = {{2019}},
}