Elongator-a tRNA modifying complex that promotes efficient translational decoding
(2018) In Biochimica et Biophysica Acta. Gene Regulatory Mechanisms 1861(4). p.401-408- Abstract
Naturally occurring modifications of the nucleosides in the anticodon region of tRNAs influence their translational decoding properties. Uridines present at the wobble position in eukaryotic cytoplasmic tRNAs often contain a 5-carbamoylmethyl (ncm(5)) or 5-methoxycarbonylmethyl (mcm(5)) side-chain and sometimes also a 2-thio or 2'-O-methyl group. The first step in the formation of the ncm(5) and mcm(5) side-chains requires the conserved six-subunit Elongator complex. Although Elongator has been implicated in several different cellular processes, accumulating evidence suggests that its primary, and possibly only, cellular function is to promote modification of tRNAs. In this review, we discuss the biosynthesis and function of modified... (More)
Naturally occurring modifications of the nucleosides in the anticodon region of tRNAs influence their translational decoding properties. Uridines present at the wobble position in eukaryotic cytoplasmic tRNAs often contain a 5-carbamoylmethyl (ncm(5)) or 5-methoxycarbonylmethyl (mcm(5)) side-chain and sometimes also a 2-thio or 2'-O-methyl group. The first step in the formation of the ncm(5) and mcm(5) side-chains requires the conserved six-subunit Elongator complex. Although Elongator has been implicated in several different cellular processes, accumulating evidence suggests that its primary, and possibly only, cellular function is to promote modification of tRNAs. In this review, we discuss the biosynthesis and function of modified wobble uridines in eukaryotic cytoplasmic tRNAs, focusing on the in vivo role of Elongator-dependent modifications in Saccharomyces cerevisiae. This article is part of a Special Issue entitled: SI: Regulation of tRNA synthesis and modification in physiological conditions and disease edited by Dr. Boguta Magdalena.
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- author
- Johansson, Marcus J O LU ; Xu, Fu and Byström, Anders S
- publishing date
- 2018-04
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Animals, Anticodon/genetics, Codon/genetics, Eukaryotic Cells/metabolism, Gene Expression Regulation, Fungal, Genetic Code, Histone Acetyltransferases/metabolism, Humans, Models, Genetic, Molecular Structure, Multiprotein Complexes/genetics, Protein Biosynthesis, RNA Processing, Post-Transcriptional, RNA, Fungal/genetics, RNA, Transfer/genetics, Saccharomyces cerevisiae/genetics, Saccharomyces cerevisiae Proteins/metabolism, Uridine/analogs & derivatives
- in
- Biochimica et Biophysica Acta. Gene Regulatory Mechanisms
- volume
- 1861
- issue
- 4
- pages
- 8 pages
- publisher
- Elsevier
- external identifiers
-
- scopus:85034852019
- pmid:29170010
- ISSN
- 1874-9399
- DOI
- 10.1016/j.bbagrm.2017.11.006
- language
- English
- LU publication?
- no
- additional info
- Copyright © 2017 Elsevier B.V. All rights reserved.
- id
- fb0f6384-c185-41a3-9a8a-8fd513aa5672
- date added to LUP
- 2024-02-28 18:13:01
- date last changed
- 2024-04-14 00:24:30
@article{fb0f6384-c185-41a3-9a8a-8fd513aa5672,
abstract = {{<p>Naturally occurring modifications of the nucleosides in the anticodon region of tRNAs influence their translational decoding properties. Uridines present at the wobble position in eukaryotic cytoplasmic tRNAs often contain a 5-carbamoylmethyl (ncm(5)) or 5-methoxycarbonylmethyl (mcm(5)) side-chain and sometimes also a 2-thio or 2'-O-methyl group. The first step in the formation of the ncm(5) and mcm(5) side-chains requires the conserved six-subunit Elongator complex. Although Elongator has been implicated in several different cellular processes, accumulating evidence suggests that its primary, and possibly only, cellular function is to promote modification of tRNAs. In this review, we discuss the biosynthesis and function of modified wobble uridines in eukaryotic cytoplasmic tRNAs, focusing on the in vivo role of Elongator-dependent modifications in Saccharomyces cerevisiae. This article is part of a Special Issue entitled: SI: Regulation of tRNA synthesis and modification in physiological conditions and disease edited by Dr. Boguta Magdalena.</p>}},
author = {{Johansson, Marcus J O and Xu, Fu and Byström, Anders S}},
issn = {{1874-9399}},
keywords = {{Animals; Anticodon/genetics; Codon/genetics; Eukaryotic Cells/metabolism; Gene Expression Regulation, Fungal; Genetic Code; Histone Acetyltransferases/metabolism; Humans; Models, Genetic; Molecular Structure; Multiprotein Complexes/genetics; Protein Biosynthesis; RNA Processing, Post-Transcriptional; RNA, Fungal/genetics; RNA, Transfer/genetics; Saccharomyces cerevisiae/genetics; Saccharomyces cerevisiae Proteins/metabolism; Uridine/analogs & derivatives}},
language = {{eng}},
number = {{4}},
pages = {{401--408}},
publisher = {{Elsevier}},
series = {{Biochimica et Biophysica Acta. Gene Regulatory Mechanisms}},
title = {{Elongator-a tRNA modifying complex that promotes efficient translational decoding}},
url = {{http://dx.doi.org/10.1016/j.bbagrm.2017.11.006}},
doi = {{10.1016/j.bbagrm.2017.11.006}},
volume = {{1861}},
year = {{2018}},
}