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Genetic Polymorphisms in Host Innate Immune Sensor Genes and the Risk of Nasopharyngeal Carcinoma in North Africa

Moumad, Khalid ; Lascorz, Jesus ; Bevier, Melanie ; Khyatti, Meriem ; Ennaji, Moulay Mustapha ; Benider, Abdellatif ; Huhn, Stefanie ; Lu, Shun ; Chouchane, Lotfi and Corbex, Marilys , et al. (2013) In G3: Genes, Genomes, Genetics 3(6). p.971-977
Abstract
Nasopharyngeal carcinoma (NPC) is a rare malignancy in most parts of the world. It is an Epstein-Barr virus-associated malignancy with an unusual racial and geographical distribution. The host innate immune sensor genes play an important role in infection recognition and immune response against viruses. Therefore, we examined the association between polymorphisms in genes within a group of pattern recognition receptors (including families of Toll-like receptors, C-type lectin receptors, and retinoic acid-inducible gene I-like receptors) and NPC susceptibility. Twenty-six single-nucleotide polymorphisms (SNPs) in five pattern-recognition genes were genotyped in 492 North African NPC cases and 373 frequency-matched controls. TLR3_rs3775291... (More)
Nasopharyngeal carcinoma (NPC) is a rare malignancy in most parts of the world. It is an Epstein-Barr virus-associated malignancy with an unusual racial and geographical distribution. The host innate immune sensor genes play an important role in infection recognition and immune response against viruses. Therefore, we examined the association between polymorphisms in genes within a group of pattern recognition receptors (including families of Toll-like receptors, C-type lectin receptors, and retinoic acid-inducible gene I-like receptors) and NPC susceptibility. Twenty-six single-nucleotide polymorphisms (SNPs) in five pattern-recognition genes were genotyped in 492 North African NPC cases and 373 frequency-matched controls. TLR3_rs3775291 was the most significantly associated SNP (odds ratio [OR] 1.49; 95% confidence interval [95% CI] 1.11-2.00; P = 0.008; dominant model). The analysis showed also that CD209_rs7248637 (OR 0.69; 95% CI 0.52-0.93; P = 0.02; dominant model) and DDX58_rs56309110 (OR 0.70; 95% CI 0.51-0.98; P = 0.04) were associated with the risk of NPC. An 18% increased risk per allele was observed for the five most significantly associated SNPs, TLR3_rs3775291, CD209_rs7248637, DDX58_rs56309110, CD209_rs4804800, and MBL2_rs10824792, (p(trend) = 8.2 x 10(-4)). Our results suggest that genetic variation in pattern-recognition genes is associated with the risk of NPC. These preliminary findings require replication in larger studies. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
nasopharyngeal carcinoma, North Africa, host innate immune sensors, SNPs, Epstein-Barr virus
in
G3: Genes, Genomes, Genetics
volume
3
issue
6
pages
971 - 977
publisher
Genetics Society of America
external identifiers
  • wos:000320768700006
  • scopus:84883207452
  • pmid:23576520
ISSN
2160-1836
DOI
10.1534/g3.112.005371
language
English
LU publication?
yes
id
fb39d417-2199-4252-a73a-4e0544925913 (old id 3983179)
date added to LUP
2016-04-01 13:11:26
date last changed
2025-04-04 14:00:50
@article{fb39d417-2199-4252-a73a-4e0544925913,
  abstract     = {{Nasopharyngeal carcinoma (NPC) is a rare malignancy in most parts of the world. It is an Epstein-Barr virus-associated malignancy with an unusual racial and geographical distribution. The host innate immune sensor genes play an important role in infection recognition and immune response against viruses. Therefore, we examined the association between polymorphisms in genes within a group of pattern recognition receptors (including families of Toll-like receptors, C-type lectin receptors, and retinoic acid-inducible gene I-like receptors) and NPC susceptibility. Twenty-six single-nucleotide polymorphisms (SNPs) in five pattern-recognition genes were genotyped in 492 North African NPC cases and 373 frequency-matched controls. TLR3_rs3775291 was the most significantly associated SNP (odds ratio [OR] 1.49; 95% confidence interval [95% CI] 1.11-2.00; P = 0.008; dominant model). The analysis showed also that CD209_rs7248637 (OR 0.69; 95% CI 0.52-0.93; P = 0.02; dominant model) and DDX58_rs56309110 (OR 0.70; 95% CI 0.51-0.98; P = 0.04) were associated with the risk of NPC. An 18% increased risk per allele was observed for the five most significantly associated SNPs, TLR3_rs3775291, CD209_rs7248637, DDX58_rs56309110, CD209_rs4804800, and MBL2_rs10824792, (p(trend) = 8.2 x 10(-4)). Our results suggest that genetic variation in pattern-recognition genes is associated with the risk of NPC. These preliminary findings require replication in larger studies.}},
  author       = {{Moumad, Khalid and Lascorz, Jesus and Bevier, Melanie and Khyatti, Meriem and Ennaji, Moulay Mustapha and Benider, Abdellatif and Huhn, Stefanie and Lu, Shun and Chouchane, Lotfi and Corbex, Marilys and Hemminki, Kari and Försti, Asta}},
  issn         = {{2160-1836}},
  keywords     = {{nasopharyngeal carcinoma; North Africa; host innate immune sensors; SNPs; Epstein-Barr virus}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{971--977}},
  publisher    = {{Genetics Society of America}},
  series       = {{G3: Genes, Genomes, Genetics}},
  title        = {{Genetic Polymorphisms in Host Innate Immune Sensor Genes and the Risk of Nasopharyngeal Carcinoma in North Africa}},
  url          = {{https://lup.lub.lu.se/search/files/3214289/4362428.pdf}},
  doi          = {{10.1534/g3.112.005371}},
  volume       = {{3}},
  year         = {{2013}},
}