Accurate T-1 Mapping for Oxygen-Enhanced MRI in the Mouse Lung Using a Segmented Inversion-Recovery Ultrashort Echo-Time Sequence
Zurek, M. ; Johansson, E. ; Risse, F. ; Alamidi, D. ; Olsson, Lars E LU
and Hockings, P. D.
(2014)
In Magnetic Resonance in Medicine
71(6).
p.2180-2185
- Abstract
- PurposeA segmented inversion-recovery module combined with the 2D ultrashort echo time radial technique is proposed that allows accurate pixel level T-1 mapping of mouse lung in vivo. MethodsNumerical simulations were performed to estimate T-1 measurement accuracy and precision versus flip angle and signal-to-noise ratio. Phantom measurements were used for protocol validation, where the segmented inversion-recovery ultrashort echo-time sequence was compared with the reference technique (inversion-recovery rapid acquisition with refocused echoes). The in vivo experiments were carried out on free-breathing C57 mice (n = 10), breathing first air and then oxygen. ResultsThe simulations demonstrated the high potential of the technique for... (More)
- PurposeA segmented inversion-recovery module combined with the 2D ultrashort echo time radial technique is proposed that allows accurate pixel level T-1 mapping of mouse lung in vivo. MethodsNumerical simulations were performed to estimate T-1 measurement accuracy and precision versus flip angle and signal-to-noise ratio. Phantom measurements were used for protocol validation, where the segmented inversion-recovery ultrashort echo-time sequence was compared with the reference technique (inversion-recovery rapid acquisition with refocused echoes). The in vivo experiments were carried out on free-breathing C57 mice (n = 10), breathing first air and then oxygen. ResultsThe simulations demonstrated the high potential of the technique for accurate and precise T-1 assessment. Phantom experiments showed good agreement for T-1 values measured with segmented inversion-recovery ultrashort echo-time and the reference technique. The in vivo experiment demonstrated the utility of the technique in oxygen-enhanced assessment, where small T-1 changes were detected with high precision. ConclusionSegmented inversion-recovery ultrashort echo-time provides accurate, high resolution T-1 mapping of the lung parenchyma. Magn Reson Med 71:2180-2185, 2014. (c) 2013 Wiley Periodicals, Inc. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4559017
- author
- Zurek, M.
; Johansson, E.
; Risse, F.
; Alamidi, D.
; Olsson, Lars E
LU
and Hockings, P. D.
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- T-1 mapping, lung MRI, ultrashort echo-time, UTE, segmented inversion, recovery, oxygen-enhanced imaging, mouse
- in
- Magnetic Resonance in Medicine
- volume
- 71
- issue
- 6
- pages
- 2180 - 2185
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000336260900025
- scopus:84900792712
- pmid:23878094
- ISSN
- 1522-2594
- DOI
- 10.1002/mrm.24876
- language
- English
- LU publication?
- yes
- id
- fb615f1a-1ad6-452c-a641-451464448e18 (old id 4559017)
- date added to LUP
- 2016-04-01 10:00:57
- date last changed
- 2022-03-12 01:15:14
@article{fb615f1a-1ad6-452c-a641-451464448e18,
abstract = {{PurposeA segmented inversion-recovery module combined with the 2D ultrashort echo time radial technique is proposed that allows accurate pixel level T-1 mapping of mouse lung in vivo. MethodsNumerical simulations were performed to estimate T-1 measurement accuracy and precision versus flip angle and signal-to-noise ratio. Phantom measurements were used for protocol validation, where the segmented inversion-recovery ultrashort echo-time sequence was compared with the reference technique (inversion-recovery rapid acquisition with refocused echoes). The in vivo experiments were carried out on free-breathing C57 mice (n = 10), breathing first air and then oxygen. ResultsThe simulations demonstrated the high potential of the technique for accurate and precise T-1 assessment. Phantom experiments showed good agreement for T-1 values measured with segmented inversion-recovery ultrashort echo-time and the reference technique. The in vivo experiment demonstrated the utility of the technique in oxygen-enhanced assessment, where small T-1 changes were detected with high precision. ConclusionSegmented inversion-recovery ultrashort echo-time provides accurate, high resolution T-1 mapping of the lung parenchyma. Magn Reson Med 71:2180-2185, 2014. (c) 2013 Wiley Periodicals, Inc.}},
author = {{Zurek, M. and Johansson, E. and Risse, F. and Alamidi, D. and Olsson, Lars E and Hockings, P. D.}},
issn = {{1522-2594}},
keywords = {{T-1 mapping; lung MRI; ultrashort echo-time; UTE; segmented inversion; recovery; oxygen-enhanced imaging; mouse}},
language = {{eng}},
number = {{6}},
pages = {{2180--2185}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Magnetic Resonance in Medicine}},
title = {{Accurate T-1 Mapping for Oxygen-Enhanced MRI in the Mouse Lung Using a Segmented Inversion-Recovery Ultrashort Echo-Time Sequence}},
url = {{http://dx.doi.org/10.1002/mrm.24876}},
doi = {{10.1002/mrm.24876}},
volume = {{71}},
year = {{2014}},
}