A high prevalence of organ-specific autoimmunity in patients with bipolar disorder.
(2004) In Biological Psychiatry 56(7). p.476-482- Abstract
- BACKGROUND: In a previous study, we reported an increased prevalence of thyroperoxidase antibodies (TPOA) in patients with bipolar disorder. Here we report the prevalence of other organ-specific autoantibodies: H/K adenosine triphosphatase (ATPA), glutamic acid decarboxylase-65 (GAD65A), and GAD-67 (GAD67A). METHODS: ATPA, GAD65A, and GAD67A were determined (via a commercially available enzyme linked immunosorbent assay for ATPA, and a standardized radio immunoassays for GAD65A and GAD67A)in the sera of 239 patients with DSM-IV bipolar disorder, in 74 patients with DSM-IV schizophrenia, and in 220 healthy control subjects. RESULTS: The positivity prevalences for ATPA and GAD65A (but not GAD67A) were elevated in bipolar patients compared... (More)
- BACKGROUND: In a previous study, we reported an increased prevalence of thyroperoxidase antibodies (TPOA) in patients with bipolar disorder. Here we report the prevalence of other organ-specific autoantibodies: H/K adenosine triphosphatase (ATPA), glutamic acid decarboxylase-65 (GAD65A), and GAD-67 (GAD67A). METHODS: ATPA, GAD65A, and GAD67A were determined (via a commercially available enzyme linked immunosorbent assay for ATPA, and a standardized radio immunoassays for GAD65A and GAD67A)in the sera of 239 patients with DSM-IV bipolar disorder, in 74 patients with DSM-IV schizophrenia, and in 220 healthy control subjects. RESULTS: The positivity prevalences for ATPA and GAD65A (but not GAD67A) were elevated in bipolar patients compared with those in healthy control subjects (11.7 vs. 6.1% and 11.3 vs. 2.6% respectively; p <.05). Schizophrenia patients did not show such statistically higher prevalence. The elevated prevalence of ATPA and GAD65A in bipolar disorder was associated with n (Less)
Please use this url to cite or link to this publication:
http://lup.lub.lu.se/record/1129991
- author
- Padmos, Roos C; Bekris, Lynn; Knijff, Esther M; Tiemeier, Henning; Kupka, Ralph W; Cohen, Dan; Nolen, Willem A; Lernmark, Åke LU and Drexhage, Hemmo A
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Biological Psychiatry
- volume
- 56
- issue
- 7
- pages
- 476 - 482
- publisher
- Society of Biological Psychiatry Published by Elsevier Inc.
- external identifiers
-
- scopus:4644250607
- ISSN
- 0006-3223
- DOI
- 10.1016/j.biopsych.2004.07.003
- language
- English
- LU publication?
- no
- id
- fb6d3944-1fd8-403d-8a6a-3740e8002861 (old id 1129991)
- date added to LUP
- 2008-06-18 08:47:57
- date last changed
- 2018-01-07 05:30:12
@article{fb6d3944-1fd8-403d-8a6a-3740e8002861, abstract = {BACKGROUND: In a previous study, we reported an increased prevalence of thyroperoxidase antibodies (TPOA) in patients with bipolar disorder. Here we report the prevalence of other organ-specific autoantibodies: H/K adenosine triphosphatase (ATPA), glutamic acid decarboxylase-65 (GAD65A), and GAD-67 (GAD67A). METHODS: ATPA, GAD65A, and GAD67A were determined (via a commercially available enzyme linked immunosorbent assay for ATPA, and a standardized radio immunoassays for GAD65A and GAD67A)in the sera of 239 patients with DSM-IV bipolar disorder, in 74 patients with DSM-IV schizophrenia, and in 220 healthy control subjects. RESULTS: The positivity prevalences for ATPA and GAD65A (but not GAD67A) were elevated in bipolar patients compared with those in healthy control subjects (11.7 vs. 6.1% and 11.3 vs. 2.6% respectively; p <.05). Schizophrenia patients did not show such statistically higher prevalence. The elevated prevalence of ATPA and GAD65A in bipolar disorder was associated with n}, author = {Padmos, Roos C and Bekris, Lynn and Knijff, Esther M and Tiemeier, Henning and Kupka, Ralph W and Cohen, Dan and Nolen, Willem A and Lernmark, Åke and Drexhage, Hemmo A}, issn = {0006-3223}, language = {eng}, number = {7}, pages = {476--482}, publisher = {Society of Biological Psychiatry Published by Elsevier Inc.}, series = {Biological Psychiatry}, title = {A high prevalence of organ-specific autoimmunity in patients with bipolar disorder.}, url = {http://dx.doi.org/10.1016/j.biopsych.2004.07.003}, volume = {56}, year = {2004}, }