Intravenous Vitamin K1 for the Correction of Prolonged Prothrombin Times in Non-Bleeding Critically Ill Patients: A Prospective Observational Study
Dahlberg, Sofia LU ; Schott, Ulf LU ; Ängeby Eriksspn, Emilia ; Tahirsylaj, Yllnor ; Schurgers, Leon and Kander, Thomas LU
(2021)
In Nutrients
13(8).
p.1-12
- Abstract
- The aim of this study was to evaluate the effects of vitamin K1 on various vitamin K-dependent proteins in critically ill patients with prolonged Owren PT. We included critically ill non-bleeding adult patients without liver failure or anticoagulation treatment, with Owren PT > 1.2, who were prescribed intravenous vitamin K1. Blood was drawn at baseline and at 20–28 h after vitamin K1 administration. At both time points, we measured various vitamin K-dependent proteins and coagulation assays. ClinicalTrials.gov; Identifier: NTC3782025. In total, 52 patients were included. Intravenous vitamin K1 reduced Owren PT, Quick PT, protein induced by vitamin K absence/antagonist-II and desphospho-uncarboxylated matrix Gla protein (dp-ucMGP), but... (More)
- The aim of this study was to evaluate the effects of vitamin K1 on various vitamin K-dependent proteins in critically ill patients with prolonged Owren PT. We included critically ill non-bleeding adult patients without liver failure or anticoagulation treatment, with Owren PT > 1.2, who were prescribed intravenous vitamin K1. Blood was drawn at baseline and at 20–28 h after vitamin K1 administration. At both time points, we measured various vitamin K-dependent proteins and coagulation assays. ClinicalTrials.gov; Identifier: NTC3782025. In total, 52 patients were included. Intravenous vitamin K1 reduced Owren PT, Quick PT, protein induced by vitamin K absence/antagonist-II and desphospho-uncarboxylated matrix Gla protein (dp-ucMGP), but not to normal levels. Concomitantly, there were increases in thrombin generation and the activity of coagulation factors II, VII, IX and X that was only counteracted with a small increase in Protein C activity. In conclusion, the results suggest that vitamin K1 strengthens coagulation as measured by PT decrease and increases in the activity of vitamin K-dependent clotting factors and thrombin generation. The decreased dp-ucMGP, and its potential positive short- and long-term non-coagulative effects, merits further research. (Less)
- Abstract (Swedish)
- The aim of this study was to evaluate the effects of vitamin K1 on various vitamin K-dependent proteins in critically ill patients with prolonged Owren PT. We included critically ill non-bleeding adult patients without liver failure or anticoagulation treatment, with Owren PT > 1.2, who were prescribed intravenous vitamin K1. Blood was drawn at baseline and at 20–28 h after vitamin K1 administration. At both time points, we measured various vitamin K-dependent proteins and coagulation assays. ClinicalTrials.gov; Identifier: NTC3782025. In total, 52 patients were included. Intravenous vitamin K1 reduced Owren PT, Quick PT, protein induced by vitamin K absence/antagonist-II and desphospho-uncarboxylated matrix Gla protein (dp-ucMGP), but... (More)
- The aim of this study was to evaluate the effects of vitamin K1 on various vitamin K-dependent proteins in critically ill patients with prolonged Owren PT. We included critically ill non-bleeding adult patients without liver failure or anticoagulation treatment, with Owren PT > 1.2, who were prescribed intravenous vitamin K1. Blood was drawn at baseline and at 20–28 h after vitamin K1 administration. At both time points, we measured various vitamin K-dependent proteins and coagulation assays. ClinicalTrials.gov; Identifier: NTC3782025. In total, 52 patients were included. Intravenous vitamin K1 reduced Owren PT, Quick PT, protein induced by vitamin K absence/antagonist-II and desphospho-uncarboxylated matrix Gla protein (dp-ucMGP), but not to normal levels. Concomitantly, there were increases in thrombin generation and the activity of coagulation factors II, VII, IX and X that was only counteracted with a small increase in Protein C activity. In conclusion, the results suggest that vitamin K1 strengthens coagulation as measured by PT decrease and increases in the activity of vitamin K-dependent clotting factors and thrombin generation. The decreased dp-ucMGP, and its potential positive short- and long-term non-coagulative effects, merits further research. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/fb91d6f9-15b6-417a-b848-55b69070cacd
- author
- Dahlberg, Sofia
LU
; Schott, Ulf
LU
; Ängeby Eriksspn, Emilia
; Tahirsylaj, Yllnor
; Schurgers, Leon
and Kander, Thomas
LU
- organization
- publishing date
- 2021-07-27
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- prothrombin; vitamin K; Gla protein; PIVKA-II; dp-ucMGP; intensive care
- in
- Nutrients
- volume
- 13
- issue
- 8
- pages
- 1 - 12
- publisher
- MDPI AG
- external identifiers
-
- scopus:85111113667
- pmid:34444740
- ISSN
- 2072-6643
- DOI
- 10.3390/nu13082580
- language
- English
- LU publication?
- yes
- id
- fb91d6f9-15b6-417a-b848-55b69070cacd
- date added to LUP
- 2021-07-31 10:58:55
- date last changed
- 2022-04-27 02:53:05
@article{fb91d6f9-15b6-417a-b848-55b69070cacd,
abstract = {{The aim of this study was to evaluate the effects of vitamin K1 on various vitamin K-dependent proteins in critically ill patients with prolonged Owren PT. We included critically ill non-bleeding adult patients without liver failure or anticoagulation treatment, with Owren PT > 1.2, who were prescribed intravenous vitamin K1. Blood was drawn at baseline and at 20–28 h after vitamin K1 administration. At both time points, we measured various vitamin K-dependent proteins and coagulation assays. ClinicalTrials.gov; Identifier: NTC3782025. In total, 52 patients were included. Intravenous vitamin K1 reduced Owren PT, Quick PT, protein induced by vitamin K absence/antagonist-II and desphospho-uncarboxylated matrix Gla protein (dp-ucMGP), but not to normal levels. Concomitantly, there were increases in thrombin generation and the activity of coagulation factors II, VII, IX and X that was only counteracted with a small increase in Protein C activity. In conclusion, the results suggest that vitamin K1 strengthens coagulation as measured by PT decrease and increases in the activity of vitamin K-dependent clotting factors and thrombin generation. The decreased dp-ucMGP, and its potential positive short- and long-term non-coagulative effects, merits further research.}},
author = {{Dahlberg, Sofia and Schott, Ulf and Ängeby Eriksspn, Emilia and Tahirsylaj, Yllnor and Schurgers, Leon and Kander, Thomas}},
issn = {{2072-6643}},
keywords = {{prothrombin; vitamin K; Gla protein; PIVKA-II; dp-ucMGP; intensive care}},
language = {{eng}},
month = {{07}},
number = {{8}},
pages = {{1--12}},
publisher = {{MDPI AG}},
series = {{Nutrients}},
title = {{Intravenous Vitamin K1 for the Correction of Prolonged Prothrombin Times in Non-Bleeding Critically Ill Patients: A Prospective Observational Study}},
url = {{http://dx.doi.org/10.3390/nu13082580}},
doi = {{10.3390/nu13082580}},
volume = {{13}},
year = {{2021}},
}