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Is increased joint loading detrimental to obese patients with knee osteoarthritis? A secondary data analysis from a randomized trial

Henriksen, M. ; Hunter, D. J. ; Dam, E. B. ; Messier, S. P. ; Andriacchi, T. P. ; Lohmander, Stefan LU orcid ; Aaboe, J. ; Boesen, M. ; Gudbergsen, H. and Bliddal, H. , et al. (2013) In Osteoarthritis and Cartilage 21(12). p.1865-1875
Abstract
Objective: To investigate whether increased knee joint loading due to improved ambulatory function and walking speed following weight loss achieved over 16 weeks accelerates symptomatic and structural disease progression over a subsequent 1 year weight maintenance period in an obese population with knee osteoarthritis (OA). Methods: Data from a prospective study of weight loss in obese patients with knee OA (the CARtilage in obese knee OsteoarThritis (CAROT) study) were used to determine changes in knee joint compressive loadings (model estimated) during walking after a successful 16 week weight loss intervention. The participants were divided into 'Unloaders' (participants that reduced joint loads) and 'Loaders' (participants that... (More)
Objective: To investigate whether increased knee joint loading due to improved ambulatory function and walking speed following weight loss achieved over 16 weeks accelerates symptomatic and structural disease progression over a subsequent 1 year weight maintenance period in an obese population with knee osteoarthritis (OA). Methods: Data from a prospective study of weight loss in obese patients with knee OA (the CARtilage in obese knee OsteoarThritis (CAROT) study) were used to determine changes in knee joint compressive loadings (model estimated) during walking after a successful 16 week weight loss intervention. The participants were divided into 'Unloaders' (participants that reduced joint loads) and 'Loaders' (participants that increased joint loads). The primary symptomatic outcome was changes in knee symptoms, measured with the Knee injury and Osteoarthritis Outcome Score (KOOS) questionnaire, during a subsequent 52 weeks weight maintenance period. The primary structural outcome was changes in tibiofemoral cartilage loss assessed semi-quantitatively (Boston Leeds Knee Osteoarthritis Score (BLOKS) from MRI after the 52 weight maintenance period. Results: 157 participants (82% of the CAROT cohort) with medial and/or lateral knee OA were classified as Unloaders (n = 100) or Loaders (n = 57). The groups showed similar significant changes in symptoms (group difference: 2.4 KOOS points [95% CI 6.8:1.91) and cartilage loss (group difference: 0.06 BLOKS points [95% CI 0.22:0.11) after 1 year, with no statistically significant differences between Loaders and Unloaders. Conclusion: For obese patients undergoing a significant weight loss, increased knee joint loading for 1 year was not associated with accelerated symptomatic and structural disease progression compared to a similar weight loss group that had reduced ambulatory compressive knee joint loads. Clinicaltrials.gov: NCT00655941. (C) 2013 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Osteoarthritis, Gait, Joint loading, Weight loss, Cartilage
in
Osteoarthritis and Cartilage
volume
21
issue
12
pages
1865 - 1875
publisher
Elsevier
external identifiers
  • wos:000329266700007
  • scopus:84888875742
  • pmid:24135273
ISSN
1063-4584
DOI
10.1016/j.joca.2013.10.003
language
English
LU publication?
yes
id
fba41f81-ff67-4f75-bdab-3560145951ac (old id 4330059)
date added to LUP
2016-04-01 09:47:43
date last changed
2023-02-28 00:32:16
@article{fba41f81-ff67-4f75-bdab-3560145951ac,
  abstract     = {{Objective: To investigate whether increased knee joint loading due to improved ambulatory function and walking speed following weight loss achieved over 16 weeks accelerates symptomatic and structural disease progression over a subsequent 1 year weight maintenance period in an obese population with knee osteoarthritis (OA). Methods: Data from a prospective study of weight loss in obese patients with knee OA (the CARtilage in obese knee OsteoarThritis (CAROT) study) were used to determine changes in knee joint compressive loadings (model estimated) during walking after a successful 16 week weight loss intervention. The participants were divided into 'Unloaders' (participants that reduced joint loads) and 'Loaders' (participants that increased joint loads). The primary symptomatic outcome was changes in knee symptoms, measured with the Knee injury and Osteoarthritis Outcome Score (KOOS) questionnaire, during a subsequent 52 weeks weight maintenance period. The primary structural outcome was changes in tibiofemoral cartilage loss assessed semi-quantitatively (Boston Leeds Knee Osteoarthritis Score (BLOKS) from MRI after the 52 weight maintenance period. Results: 157 participants (82% of the CAROT cohort) with medial and/or lateral knee OA were classified as Unloaders (n = 100) or Loaders (n = 57). The groups showed similar significant changes in symptoms (group difference: 2.4 KOOS points [95% CI 6.8:1.91) and cartilage loss (group difference: 0.06 BLOKS points [95% CI 0.22:0.11) after 1 year, with no statistically significant differences between Loaders and Unloaders. Conclusion: For obese patients undergoing a significant weight loss, increased knee joint loading for 1 year was not associated with accelerated symptomatic and structural disease progression compared to a similar weight loss group that had reduced ambulatory compressive knee joint loads. Clinicaltrials.gov: NCT00655941. (C) 2013 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.}},
  author       = {{Henriksen, M. and Hunter, D. J. and Dam, E. B. and Messier, S. P. and Andriacchi, T. P. and Lohmander, Stefan and Aaboe, J. and Boesen, M. and Gudbergsen, H. and Bliddal, H. and Christensen, R.}},
  issn         = {{1063-4584}},
  keywords     = {{Osteoarthritis; Gait; Joint loading; Weight loss; Cartilage}},
  language     = {{eng}},
  number       = {{12}},
  pages        = {{1865--1875}},
  publisher    = {{Elsevier}},
  series       = {{Osteoarthritis and Cartilage}},
  title        = {{Is increased joint loading detrimental to obese patients with knee osteoarthritis? A secondary data analysis from a randomized trial}},
  url          = {{http://dx.doi.org/10.1016/j.joca.2013.10.003}},
  doi          = {{10.1016/j.joca.2013.10.003}},
  volume       = {{21}},
  year         = {{2013}},
}