Pressure-driven release of viral genome into a host nucleus is a mechanism leading to herpes infection
Brandariz-Nuñez, Alberto ; Liu, Ting ; Du, Te and Evilevitch, Alex LU
(2019)
In eLife
8.
- Abstract
Many viruses previously have been shown to have pressurized genomes inside their viral protein shell, termed the capsid. This pressure results from the tight confinement of negatively charged viral nucleic acids inside the capsid. However, the relevance of capsid pressure to viral infection has not been demonstrated. In this work, we show that the internal DNA pressure of tens of atmospheres inside a herpesvirus capsid powers ejection of the viral genome into a host cell nucleus. To our knowledge, this provides the first demonstration of a pressure-dependent mechanism of viral genome penetration into a host nucleus, leading to infection of eukaryotic cells.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/fbc4c029-d2e5-4fb8-9690-9261517a7f3f
- author
- Brandariz-Nuñez, Alberto
; Liu, Ting
; Du, Te
and Evilevitch, Alex
LU
- organization
- publishing date
- 2019-08-08
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- cell nucleus, DNA ejection, DNA pressure, herpes capsid, herpesvirus, infectious disease, microbiology, physics of living systems, pressure-driven DNA ejection, virus
- in
- eLife
- volume
- 8
- article number
- e47212
- publisher
- eLife Sciences Publications
- external identifiers
-
- scopus:85071713393
- pmid:31393262
- ISSN
- 2050-084X
- DOI
- 10.7554/eLife.47212
- language
- English
- LU publication?
- yes
- id
- fbc4c029-d2e5-4fb8-9690-9261517a7f3f
- date added to LUP
- 2019-09-19 11:09:53
- date last changed
- 2024-02-15 20:52:54
@article{fbc4c029-d2e5-4fb8-9690-9261517a7f3f,
abstract = {{<p>Many viruses previously have been shown to have pressurized genomes inside their viral protein shell, termed the capsid. This pressure results from the tight confinement of negatively charged viral nucleic acids inside the capsid. However, the relevance of capsid pressure to viral infection has not been demonstrated. In this work, we show that the internal DNA pressure of tens of atmospheres inside a herpesvirus capsid powers ejection of the viral genome into a host cell nucleus. To our knowledge, this provides the first demonstration of a pressure-dependent mechanism of viral genome penetration into a host nucleus, leading to infection of eukaryotic cells.</p>}},
author = {{Brandariz-Nuñez, Alberto and Liu, Ting and Du, Te and Evilevitch, Alex}},
issn = {{2050-084X}},
keywords = {{cell nucleus; DNA ejection; DNA pressure; herpes capsid; herpesvirus; infectious disease; microbiology; physics of living systems; pressure-driven DNA ejection; virus}},
language = {{eng}},
month = {{08}},
publisher = {{eLife Sciences Publications}},
series = {{eLife}},
title = {{Pressure-driven release of viral genome into a host nucleus is a mechanism leading to herpes infection}},
url = {{http://dx.doi.org/10.7554/eLife.47212}},
doi = {{10.7554/eLife.47212}},
volume = {{8}},
year = {{2019}},
}