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Hypertonic Saline Infusion Acutely Degrades Mood in Healthy Volunteers (P23-014-19)

Suh, HyunGyu; Lieberman, Harris; Jansen, Lisa; Adams, J D; Seal, Adam; Butts, Cory; Colburn, Abigail; Kirkland, Tracie; Sprong, Cameron and Melander, Olle LU , et al. (2019) In Current Development in Nutrition 3(Suppl 1).
Abstract

Objectives: Mild and moderate dehydration adversely affect mood and cognitive function. During dehydration, hypertonic hypovolemia activates both osmo- and baro-receptors but it is not known which physiological pathway is associated with degraded mood state. This study examined the acute effect of osmoreceptor stimulation on mood.

Methods: Sixty healthy adults (50% females, 30 ± 1 y; BMI: 26.9 ± 4.0 kg·m-2) were infused intravenously with 3.0% (HYPER) or 0.9% (ISO) NaCl for 2 h (0.1 ml·kg-1·min-1) using a counterbalanced, crossover design. Blood samples were collected every 30 minutes to measure plasma osmolality (POsm), copeptin (a surrogate marker of vasopressin), and renin-angiotensin-aldosterone system (RAAS) hormones. Mood... (More)

Objectives: Mild and moderate dehydration adversely affect mood and cognitive function. During dehydration, hypertonic hypovolemia activates both osmo- and baro-receptors but it is not known which physiological pathway is associated with degraded mood state. This study examined the acute effect of osmoreceptor stimulation on mood.

Methods: Sixty healthy adults (50% females, 30 ± 1 y; BMI: 26.9 ± 4.0 kg·m-2) were infused intravenously with 3.0% (HYPER) or 0.9% (ISO) NaCl for 2 h (0.1 ml·kg-1·min-1) using a counterbalanced, crossover design. Blood samples were collected every 30 minutes to measure plasma osmolality (POsm), copeptin (a surrogate marker of vasopressin), and renin-angiotensin-aldosterone system (RAAS) hormones. Mood was assessed with the short version of Profile of Mood State (POMS) questionnaire before and after the infusion.

Results: POsm and copeptin increased from 286 ± 3 mmol·kg-1 to 305 ± 4 mmol·kg-1 and from 4.5 ± 3.7 pmol·L-1 to 20.4 ± 12.8 pmol·L-1, respectively in HYPER (P < 0.05), and were unchanged in ISO (P > 0.05). No hormonal differences were observed between trials for RAAS hormones (P > 0.05). During HYPER copeptin, following the 2-h infusion, was greater in females than in males (female: 23.4 ± 13.9 pmol·L-1, male: 17.4 ± 10.9 pmol·L-1; P < 0.05). The POMS total mood disturbance (TMD) score increased from 10.5 ± 0.9 to 16.5 ± 1.6 in HYPER (P < 0.05), but not in ISO (P > 0.05). Among POMS subscales, depression-dejection and fatigue-inertia increased in HYPER compared to ISO (P < 0.05). When TMD responses in the HYPER trial were analyzed with sex as a between-subjects factor, the increase was significant in females (pre: 10.2 ± 1.0, post: 18.6 ± 2.3; P < 0.001) but not in males (pre: 10.8 ± 1.4, post: 14.0 ± 2.0; P > 0.05). The confusion-bewilderment subscales and fatigue-inertia of the POMS were also elevated post HYPER in females (P < 0.05), but not in ISO (P > 0.05) in either sex.

Conclusions: Hypertonic saline infusion acutely degrades mood state, and women appear to have a more pronounced response. The underlying mechanisms remain to be determined but may be related to higher copeptin levels in women.The study was registered at ClinicalTrials.gov as NCT02761434.

Funding Sources: Danone Research.

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Current Development in Nutrition
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3
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Suppl 1
ISSN
2475-2991
DOI
10.1093/cdn/nzz043.P23-014-19
language
English
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yes
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fbd0ae83-eb48-4813-bf6c-a92049ef36c0
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6574458/
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2019-07-11 13:37:05
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2019-07-11 13:37:05
@article{fbd0ae83-eb48-4813-bf6c-a92049ef36c0,
  abstract     = {<p>Objectives: Mild and moderate dehydration adversely affect mood and cognitive function. During dehydration, hypertonic hypovolemia activates both osmo- and baro-receptors but it is not known which physiological pathway is associated with degraded mood state. This study examined the acute effect of osmoreceptor stimulation on mood.</p><p>Methods: Sixty healthy adults (50% females, 30 ± 1 y; BMI: 26.9 ± 4.0 kg·m-2) were infused intravenously with 3.0% (HYPER) or 0.9% (ISO) NaCl for 2 h (0.1 ml·kg-1·min-1) using a counterbalanced, crossover design. Blood samples were collected every 30 minutes to measure plasma osmolality (POsm), copeptin (a surrogate marker of vasopressin), and renin-angiotensin-aldosterone system (RAAS) hormones. Mood was assessed with the short version of Profile of Mood State (POMS) questionnaire before and after the infusion.</p><p>Results: POsm and copeptin increased from 286 ± 3 mmol·kg-1 to 305 ± 4 mmol·kg-1 and from 4.5 ± 3.7 pmol·L-1 to 20.4 ± 12.8 pmol·L-1, respectively in HYPER (P &lt; 0.05), and were unchanged in ISO (P &gt; 0.05). No hormonal differences were observed between trials for RAAS hormones (P &gt; 0.05). During HYPER copeptin, following the 2-h infusion, was greater in females than in males (female: 23.4 ± 13.9 pmol·L-1, male: 17.4 ± 10.9 pmol·L-1; P &lt; 0.05). The POMS total mood disturbance (TMD) score increased from 10.5 ± 0.9 to 16.5 ± 1.6 in HYPER (P &lt; 0.05), but not in ISO (P &gt; 0.05). Among POMS subscales, depression-dejection and fatigue-inertia increased in HYPER compared to ISO (P &lt; 0.05). When TMD responses in the HYPER trial were analyzed with sex as a between-subjects factor, the increase was significant in females (pre: 10.2 ± 1.0, post: 18.6 ± 2.3; P &lt; 0.001) but not in males (pre: 10.8 ± 1.4, post: 14.0 ± 2.0; P &gt; 0.05). The confusion-bewilderment subscales and fatigue-inertia of the POMS were also elevated post HYPER in females (P &lt; 0.05), but not in ISO (P &gt; 0.05) in either sex.</p><p>Conclusions: Hypertonic saline infusion acutely degrades mood state, and women appear to have a more pronounced response. The underlying mechanisms remain to be determined but may be related to higher copeptin levels in women.The study was registered at ClinicalTrials.gov as NCT02761434.</p><p>Funding Sources: Danone Research.</p><p>Supporting Tables Images and/or Graphs: </p>},
  author       = {Suh, HyunGyu and Lieberman, Harris and Jansen, Lisa and Adams, J D and Seal, Adam and Butts, Cory and Colburn, Abigail and Kirkland, Tracie and Sprong, Cameron and Melander, Olle and Lemetais, Guillaume and Vanhaecke, Tiphaine and Dolci, Alberto and Perrier, Erica and Kavouras, Stavros},
  issn         = {2475-2991},
  language     = {eng},
  number       = {Suppl 1},
  series       = {Current Development in Nutrition},
  title        = {Hypertonic Saline Infusion Acutely Degrades Mood in Healthy Volunteers (P23-014-19)},
  url          = {http://dx.doi.org/10.1093/cdn/nzz043.P23-014-19},
  volume       = {3},
  year         = {2019},
}