Effect of epinephrine and mannoheptulose on early and late phases of glucose-stimulated insulin release
Lernmark, Ake LU
and Hellman, Bo
(1970)
In Metabolism
19(8).
p.614-618
- Abstract
Previous studies have revealed the existence of two separate phases in the glucose-stimulated insulin release. Exposure of microdissected mouse islets to mannoheptulose or epinephrine effectively inhibited both the initial transient release and the second persistent phase of insulin secretion. These results suggest that metabolism of glucose is a prerequisite for both phases of insulin release. The current view of mannoheptulose as an inhibitor of the β-cell phosphorylation of glucose was corroborated by the observation that this drug prevented the increase of fructose-1,6-diphosphate normally observed with increasing glucose levels.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/fc1792b4-118f-4446-a04d-4ca34f281cd9
- author
- Lernmark, Ake
LU
and Hellman, Bo
- publishing date
- 1970-01-01
- type
- Contribution to journal
- publication status
- published
- in
- Metabolism
- volume
- 19
- issue
- 8
- pages
- 614 - 618
- publisher
- Elsevier
- external identifiers
-
- scopus:0014831169
- pmid:4913911
- ISSN
- 0026-0495
- DOI
- 10.1016/0026-0495(70)90018-1
- language
- English
- LU publication?
- no
- id
- fc1792b4-118f-4446-a04d-4ca34f281cd9
- date added to LUP
- 2019-09-18 12:26:17
- date last changed
- 2024-03-13 08:01:29
@article{fc1792b4-118f-4446-a04d-4ca34f281cd9,
abstract = {{<p>Previous studies have revealed the existence of two separate phases in the glucose-stimulated insulin release. Exposure of microdissected mouse islets to mannoheptulose or epinephrine effectively inhibited both the initial transient release and the second persistent phase of insulin secretion. These results suggest that metabolism of glucose is a prerequisite for both phases of insulin release. The current view of mannoheptulose as an inhibitor of the β-cell phosphorylation of glucose was corroborated by the observation that this drug prevented the increase of fructose-1,6-diphosphate normally observed with increasing glucose levels.</p>}},
author = {{Lernmark, Ake and Hellman, Bo}},
issn = {{0026-0495}},
language = {{eng}},
month = {{01}},
number = {{8}},
pages = {{614--618}},
publisher = {{Elsevier}},
series = {{Metabolism}},
title = {{Effect of epinephrine and mannoheptulose on early and late phases of glucose-stimulated insulin release}},
url = {{http://dx.doi.org/10.1016/0026-0495(70)90018-1}},
doi = {{10.1016/0026-0495(70)90018-1}},
volume = {{19}},
year = {{1970}},
}