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Pattern of endocrine treatment for epithelial ovarian cancer in the Southeast medical region of Sweden : a population-based study

Bagge, Ebba; Beiron, Ulrica; Malander, Susanne LU ; Rosenberg, Per and Åvall-Lundqvist, Elisabeth (2019) In Acta Oncologica 58(3). p.320-325
Abstract

Aim of the study: Endocrine treatment (ET) is an alternative as salvage therapy in epithelial ovarian cancer (EOC) but the usage in routine care is unknown. We evaluated the treatment patterns and outcome of patients receiving ET for EOC in the Southeast medical region in Sweden. Method: Patients were identified through the population-based Southeast Quality Registry for gynaecological cancer. Inclusion criteria were: age ≥18 years, histologically verified EOC diagnosed 2000–2013, ET for ≥4 weeks. Coverage compared with the Swedish National Cancer Registry was 100%. Data extracted from medical records was collected by means of a study-specific Case Report Form. Last date of follow-up was February 1st, 2018. All statistics were... (More)

Aim of the study: Endocrine treatment (ET) is an alternative as salvage therapy in epithelial ovarian cancer (EOC) but the usage in routine care is unknown. We evaluated the treatment patterns and outcome of patients receiving ET for EOC in the Southeast medical region in Sweden. Method: Patients were identified through the population-based Southeast Quality Registry for gynaecological cancer. Inclusion criteria were: age ≥18 years, histologically verified EOC diagnosed 2000–2013, ET for ≥4 weeks. Coverage compared with the Swedish National Cancer Registry was 100%. Data extracted from medical records was collected by means of a study-specific Case Report Form. Last date of follow-up was February 1st, 2018. All statistics were descriptive. Results: Altogether 248 (18%) of 1414 patients were treated with ET. Most (49%) had received only one, and 34% two previous lines of chemotherapy. Time from last chemotherapy to ET was 4 months, range 0–55months. The reason for initiating ET was tumor progression (66%), chemotherapy related toxicity (29%) and maintenance (4%). Tamoxifen was prescribed in 94% of cases. Best response was partial (< 5%) and stable disease (50%). No patient had a complete response. 194 (78%) patients received subsequent chemotherapy, of these 27% had 3–7 lines of chemotherapy. Duration of ET was a median 4 months (range 1–80 months). Median time from ET to subsequent chemotherapy was 5 months (range 0–79). The median overall survival was 45 months (range 9–173). Conclusion: In the Southeast region of Sweden, endocrine treatment for EOC was prescribed inconsistently and in various settings, usually initiated by a rising CA-125 level. Poorer documentation and irregular tumor response assessment were observed for endocrine treatment compared to chemotherapy.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Oncologica
volume
58
issue
3
pages
6 pages
publisher
Taylor & Francis
external identifiers
  • scopus:85063683772
ISSN
0284-186X
DOI
10.1080/0284186X.2018.1546061
language
English
LU publication?
yes
id
fc3d9f1b-14b8-4b94-89c5-b0c2bae0a0f3
date added to LUP
2019-04-10 10:41:09
date last changed
2019-05-08 02:30:24
@article{fc3d9f1b-14b8-4b94-89c5-b0c2bae0a0f3,
  abstract     = {<p>Aim of the study: Endocrine treatment (ET) is an alternative as salvage therapy in epithelial ovarian cancer (EOC) but the usage in routine care is unknown. We evaluated the treatment patterns and outcome of patients receiving ET for EOC in the Southeast medical region in Sweden. Method: Patients were identified through the population-based Southeast Quality Registry for gynaecological cancer. Inclusion criteria were: age ≥18 years, histologically verified EOC diagnosed 2000–2013, ET for ≥4 weeks. Coverage compared with the Swedish National Cancer Registry was 100%. Data extracted from medical records was collected by means of a study-specific Case Report Form. Last date of follow-up was February 1st, 2018. All statistics were descriptive. Results: Altogether 248 (18%) of 1414 patients were treated with ET. Most (49%) had received only one, and 34% two previous lines of chemotherapy. Time from last chemotherapy to ET was 4 months, range 0–55months. The reason for initiating ET was tumor progression (66%), chemotherapy related toxicity (29%) and maintenance (4%). Tamoxifen was prescribed in 94% of cases. Best response was partial (&lt; 5%) and stable disease (50%). No patient had a complete response. 194 (78%) patients received subsequent chemotherapy, of these 27% had 3–7 lines of chemotherapy. Duration of ET was a median 4 months (range 1–80 months). Median time from ET to subsequent chemotherapy was 5 months (range 0–79). The median overall survival was 45 months (range 9–173). Conclusion: In the Southeast region of Sweden, endocrine treatment for EOC was prescribed inconsistently and in various settings, usually initiated by a rising CA-125 level. Poorer documentation and irregular tumor response assessment were observed for endocrine treatment compared to chemotherapy.</p>},
  author       = {Bagge, Ebba and Beiron, Ulrica and Malander, Susanne and Rosenberg, Per and Åvall-Lundqvist, Elisabeth},
  issn         = {0284-186X},
  language     = {eng},
  number       = {3},
  pages        = {320--325},
  publisher    = {Taylor & Francis},
  series       = {Acta Oncologica},
  title        = {Pattern of endocrine treatment for epithelial ovarian cancer in the Southeast medical region of Sweden : a population-based study},
  url          = {http://dx.doi.org/10.1080/0284186X.2018.1546061},
  volume       = {58},
  year         = {2019},
}