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Midsagittal corpus callosal thickness and cognitive impairment in Parkinson's disease

Owens-Walton, Conor ; Adamson, Chris ; Walterfang, Mark ; Hall, Sara LU ; van Westen, Danielle LU orcid ; Hansson, Oskar LU orcid ; Shaw, Marnie and Looi, Jeffrey C.L. (2022) In European Journal of Neuroscience 55(7). p.1859-1872
Abstract

People diagnosed with Parkinson's disease (PD) can experience significant neuropsychiatric symptoms, including cognitive impairment and dementia, the neuroanatomical substrates of which are not fully characterised. Symptoms associated with cognitive impairment and dementia in PD may relate to direct structural changes to the corpus callosum via primary white matter pathology or as a secondary outcome due to the degeneration of cortical regions. Using magnetic resonance imaging, the corpus callosum can be investigated at the midsagittal plane, where it converges to a contiguous mass and is not intertwined with other tracts. The objective of this project was thus twofold: First, we investigated possible changes in the thickness of the... (More)

People diagnosed with Parkinson's disease (PD) can experience significant neuropsychiatric symptoms, including cognitive impairment and dementia, the neuroanatomical substrates of which are not fully characterised. Symptoms associated with cognitive impairment and dementia in PD may relate to direct structural changes to the corpus callosum via primary white matter pathology or as a secondary outcome due to the degeneration of cortical regions. Using magnetic resonance imaging, the corpus callosum can be investigated at the midsagittal plane, where it converges to a contiguous mass and is not intertwined with other tracts. The objective of this project was thus twofold: First, we investigated possible changes in the thickness of the midsagittal callosum and cortex in patients with PD with varying levels of cognitive impairment; and secondly, we investigated the relationship between the thickness of the midsagittal corpus callosum and the thickness of the cortex. Study participants included cognitively unimpaired PD participants (n = 35), PD participants with mild cognitive impairment (n = 22), PD participants with dementia (n = 17) and healthy controls (n = 27). We found thinning of the callosum in PD-related dementia compared with PD-related mild cognitive impairment and cognitively unimpaired PD participants. Regression analyses found thickness of the left medial orbitofrontal cortex to be positively correlated with thickness of the anterior callosum in PD-related mild cognitive impairment. This study suggests that a midsagittal thickness model can uncover changes to the corpus callosum in PD-related dementia, which occur in line with changes to the cortex in this advanced disease stage.

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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
corpus callosum, dementia, mild cognitive impairment, Parkinson's disease
in
European Journal of Neuroscience
volume
55
issue
7
pages
14 pages
publisher
Wiley-Blackwell
external identifiers
  • pmid:35274408
  • scopus:85126817936
ISSN
0953-816X
DOI
10.1111/ejn.15640
language
English
LU publication?
yes
id
fc5f7082-4221-4423-92db-b2cb1e577fdb
date added to LUP
2022-04-20 08:30:34
date last changed
2024-03-24 23:57:20
@article{fc5f7082-4221-4423-92db-b2cb1e577fdb,
  abstract     = {{<p>People diagnosed with Parkinson's disease (PD) can experience significant neuropsychiatric symptoms, including cognitive impairment and dementia, the neuroanatomical substrates of which are not fully characterised. Symptoms associated with cognitive impairment and dementia in PD may relate to direct structural changes to the corpus callosum via primary white matter pathology or as a secondary outcome due to the degeneration of cortical regions. Using magnetic resonance imaging, the corpus callosum can be investigated at the midsagittal plane, where it converges to a contiguous mass and is not intertwined with other tracts. The objective of this project was thus twofold: First, we investigated possible changes in the thickness of the midsagittal callosum and cortex in patients with PD with varying levels of cognitive impairment; and secondly, we investigated the relationship between the thickness of the midsagittal corpus callosum and the thickness of the cortex. Study participants included cognitively unimpaired PD participants (n = 35), PD participants with mild cognitive impairment (n = 22), PD participants with dementia (n = 17) and healthy controls (n = 27). We found thinning of the callosum in PD-related dementia compared with PD-related mild cognitive impairment and cognitively unimpaired PD participants. Regression analyses found thickness of the left medial orbitofrontal cortex to be positively correlated with thickness of the anterior callosum in PD-related mild cognitive impairment. This study suggests that a midsagittal thickness model can uncover changes to the corpus callosum in PD-related dementia, which occur in line with changes to the cortex in this advanced disease stage.</p>}},
  author       = {{Owens-Walton, Conor and Adamson, Chris and Walterfang, Mark and Hall, Sara and van Westen, Danielle and Hansson, Oskar and Shaw, Marnie and Looi, Jeffrey C.L.}},
  issn         = {{0953-816X}},
  keywords     = {{corpus callosum; dementia; mild cognitive impairment; Parkinson's disease}},
  language     = {{eng}},
  number       = {{7}},
  pages        = {{1859--1872}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{European Journal of Neuroscience}},
  title        = {{Midsagittal corpus callosal thickness and cognitive impairment in Parkinson's disease}},
  url          = {{http://dx.doi.org/10.1111/ejn.15640}},
  doi          = {{10.1111/ejn.15640}},
  volume       = {{55}},
  year         = {{2022}},
}