Dairy Intake and Parkinson's Disease : A Mendelian Randomization Study
(2022) In Movement Disorders 37(4). p.857-864- Abstract
BACKGROUND: Previous prospective studies highlighted dairy intake as a risk factor for Parkinson's disease (PD), particularly in men. It is unclear whether this association is causal or explained by reverse causation or confounding.
OBJECTIVE: The aim is to examine the association between genetically predicted dairy intake and PD using two-sample Mendelian randomization (MR).
METHODS: We genotyped a well-established instrumental variable for dairy intake located in the lactase gene (rs4988235) within the Courage-PD consortium (23 studies; 9823 patients and 8376 controls of European ancestry).
RESULTS: Based on a dominant model, there was an association between genetic predisposition toward higher dairy intake and PD... (More)
BACKGROUND: Previous prospective studies highlighted dairy intake as a risk factor for Parkinson's disease (PD), particularly in men. It is unclear whether this association is causal or explained by reverse causation or confounding.
OBJECTIVE: The aim is to examine the association between genetically predicted dairy intake and PD using two-sample Mendelian randomization (MR).
METHODS: We genotyped a well-established instrumental variable for dairy intake located in the lactase gene (rs4988235) within the Courage-PD consortium (23 studies; 9823 patients and 8376 controls of European ancestry).
RESULTS: Based on a dominant model, there was an association between genetic predisposition toward higher dairy intake and PD (odds ratio [OR] per one serving per day = 1.70, 95% confidence interval = 1.12-2.60, P = 0.013) that was restricted to men (OR = 2.50 [1.37-4.56], P = 0.003; P-difference with women = 0.029).
CONCLUSIONS: Using MR, our findings provide further support for a causal relationship between dairy intake and higher PD risk, not biased by confounding or reverse causation. Further studies are needed to elucidate the underlying mechanisms. © 2022 International Parkinson and Movement Disorder Society.
(Less)
- author
- Domenighetti, Cloé ; Puschmann, Andreas LU ; Hellberg, Clara LU and Elbaz, Alexis
- author collaboration
- organization
- publishing date
- 2022-04
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Dairy Products/adverse effects, Female, Genetic Predisposition to Disease/genetics, Genome-Wide Association Study, Humans, Male, Mendelian Randomization Analysis, Parkinson Disease/epidemiology, Polymorphism, Single Nucleotide/genetics, Risk Factors
- in
- Movement Disorders
- volume
- 37
- issue
- 4
- pages
- 857 - 864
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- pmid:34997937
- scopus:85128406510
- ISSN
- 0885-3185
- DOI
- 10.1002/mds.28902
- language
- English
- LU publication?
- yes
- additional info
- © 2022 International Parkinson and Movement Disorder Society.
- id
- fc715f43-b694-4cd7-8633-a4cfb1ae93ef
- date added to LUP
- 2022-08-16 15:23:04
- date last changed
- 2024-09-21 10:01:36
@article{fc715f43-b694-4cd7-8633-a4cfb1ae93ef, abstract = {{<p>BACKGROUND: Previous prospective studies highlighted dairy intake as a risk factor for Parkinson's disease (PD), particularly in men. It is unclear whether this association is causal or explained by reverse causation or confounding.</p><p>OBJECTIVE: The aim is to examine the association between genetically predicted dairy intake and PD using two-sample Mendelian randomization (MR).</p><p>METHODS: We genotyped a well-established instrumental variable for dairy intake located in the lactase gene (rs4988235) within the Courage-PD consortium (23 studies; 9823 patients and 8376 controls of European ancestry).</p><p>RESULTS: Based on a dominant model, there was an association between genetic predisposition toward higher dairy intake and PD (odds ratio [OR] per one serving per day = 1.70, 95% confidence interval = 1.12-2.60, P = 0.013) that was restricted to men (OR = 2.50 [1.37-4.56], P = 0.003; P-difference with women = 0.029).</p><p>CONCLUSIONS: Using MR, our findings provide further support for a causal relationship between dairy intake and higher PD risk, not biased by confounding or reverse causation. Further studies are needed to elucidate the underlying mechanisms. © 2022 International Parkinson and Movement Disorder Society.</p>}}, author = {{Domenighetti, Cloé and Puschmann, Andreas and Hellberg, Clara and Elbaz, Alexis}}, issn = {{0885-3185}}, keywords = {{Dairy Products/adverse effects; Female; Genetic Predisposition to Disease/genetics; Genome-Wide Association Study; Humans; Male; Mendelian Randomization Analysis; Parkinson Disease/epidemiology; Polymorphism, Single Nucleotide/genetics; Risk Factors}}, language = {{eng}}, number = {{4}}, pages = {{857--864}}, publisher = {{John Wiley & Sons Inc.}}, series = {{Movement Disorders}}, title = {{Dairy Intake and Parkinson's Disease : A Mendelian Randomization Study}}, url = {{http://dx.doi.org/10.1002/mds.28902}}, doi = {{10.1002/mds.28902}}, volume = {{37}}, year = {{2022}}, }