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Dairy Intake and Parkinson's Disease : A Mendelian Randomization Study

Domenighetti, Cloé ; Puschmann, Andreas LU orcid ; Hellberg, Clara LU and Elbaz, Alexis (2022) In Movement Disorders 37(4). p.857-864
Abstract

BACKGROUND: Previous prospective studies highlighted dairy intake as a risk factor for Parkinson's disease (PD), particularly in men. It is unclear whether this association is causal or explained by reverse causation or confounding.

OBJECTIVE: The aim is to examine the association between genetically predicted dairy intake and PD using two-sample Mendelian randomization (MR).

METHODS: We genotyped a well-established instrumental variable for dairy intake located in the lactase gene (rs4988235) within the Courage-PD consortium (23 studies; 9823 patients and 8376 controls of European ancestry).

RESULTS: Based on a dominant model, there was an association between genetic predisposition toward higher dairy intake and PD... (More)

BACKGROUND: Previous prospective studies highlighted dairy intake as a risk factor for Parkinson's disease (PD), particularly in men. It is unclear whether this association is causal or explained by reverse causation or confounding.

OBJECTIVE: The aim is to examine the association between genetically predicted dairy intake and PD using two-sample Mendelian randomization (MR).

METHODS: We genotyped a well-established instrumental variable for dairy intake located in the lactase gene (rs4988235) within the Courage-PD consortium (23 studies; 9823 patients and 8376 controls of European ancestry).

RESULTS: Based on a dominant model, there was an association between genetic predisposition toward higher dairy intake and PD (odds ratio [OR] per one serving per day = 1.70, 95% confidence interval = 1.12-2.60, P = 0.013) that was restricted to men (OR = 2.50 [1.37-4.56], P = 0.003; P-difference with women = 0.029).

CONCLUSIONS: Using MR, our findings provide further support for a causal relationship between dairy intake and higher PD risk, not biased by confounding or reverse causation. Further studies are needed to elucidate the underlying mechanisms. © 2022 International Parkinson and Movement Disorder Society.

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author
; ; and
author collaboration
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Dairy Products/adverse effects, Female, Genetic Predisposition to Disease/genetics, Genome-Wide Association Study, Humans, Male, Mendelian Randomization Analysis, Parkinson Disease/epidemiology, Polymorphism, Single Nucleotide/genetics, Risk Factors
in
Movement Disorders
volume
37
issue
4
pages
857 - 864
publisher
John Wiley & Sons Inc.
external identifiers
  • scopus:85128406510
  • pmid:34997937
ISSN
0885-3185
DOI
10.1002/mds.28902
language
English
LU publication?
yes
additional info
© 2022 International Parkinson and Movement Disorder Society.
id
fc715f43-b694-4cd7-8633-a4cfb1ae93ef
date added to LUP
2022-08-16 15:23:04
date last changed
2024-06-29 02:05:53
@article{fc715f43-b694-4cd7-8633-a4cfb1ae93ef,
  abstract     = {{<p>BACKGROUND: Previous prospective studies highlighted dairy intake as a risk factor for Parkinson's disease (PD), particularly in men. It is unclear whether this association is causal or explained by reverse causation or confounding.</p><p>OBJECTIVE: The aim is to examine the association between genetically predicted dairy intake and PD using two-sample Mendelian randomization (MR).</p><p>METHODS: We genotyped a well-established instrumental variable for dairy intake located in the lactase gene (rs4988235) within the Courage-PD consortium (23 studies; 9823 patients and 8376 controls of European ancestry).</p><p>RESULTS: Based on a dominant model, there was an association between genetic predisposition toward higher dairy intake and PD (odds ratio [OR] per one serving per day = 1.70, 95% confidence interval = 1.12-2.60, P = 0.013) that was restricted to men (OR = 2.50 [1.37-4.56], P = 0.003; P-difference with women = 0.029).</p><p>CONCLUSIONS: Using MR, our findings provide further support for a causal relationship between dairy intake and higher PD risk, not biased by confounding or reverse causation. Further studies are needed to elucidate the underlying mechanisms. © 2022 International Parkinson and Movement Disorder Society.</p>}},
  author       = {{Domenighetti, Cloé and Puschmann, Andreas and Hellberg, Clara and Elbaz, Alexis}},
  issn         = {{0885-3185}},
  keywords     = {{Dairy Products/adverse effects; Female; Genetic Predisposition to Disease/genetics; Genome-Wide Association Study; Humans; Male; Mendelian Randomization Analysis; Parkinson Disease/epidemiology; Polymorphism, Single Nucleotide/genetics; Risk Factors}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{857--864}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Movement Disorders}},
  title        = {{Dairy Intake and Parkinson's Disease : A Mendelian Randomization Study}},
  url          = {{http://dx.doi.org/10.1002/mds.28902}},
  doi          = {{10.1002/mds.28902}},
  volume       = {{37}},
  year         = {{2022}},
}