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Heterogeneity of islet pathology in two infants with recent onset diabetes mellitus

Lernmark, Å LU orcid ; Stenger, D. ; Baskin, D. G. ; Palmer, J. P. ; Li, L. ; Klöppel, G. ; Vathanaprida, C. ; Fält, K. ; Landin-Olsson, M. LU and Gown, A. M. , et al. (1995) In Virchows Archiv 425(6). p.631-640
Abstract

The mechanisms by which the beta cells of pancreatic islets are destroyed in insulin-dependent diabetes mellitus (IDDM) are poorly understood. In this report the pancreatic histo- and immunopathology of two children, both HLA-DR 3/4, DQ 2/8 positive and who both died from cerebral oedema within a day of clinical diagnosis of IDDM, were investigated. Patient 1, a 14-month-old girl, had a 4-week history of polydipsia and polyuria. Patient 2, a 3-year-old boy, had 2 days of illness. Both patients had a similarly severe loss of insulin cells but differed markedly as to the extent of lymphocytic islet infiltration (insulitis). Apart from insulitis, marked islet macrophage infiltration was demonstrated in both patients with the HAM-56... (More)

The mechanisms by which the beta cells of pancreatic islets are destroyed in insulin-dependent diabetes mellitus (IDDM) are poorly understood. In this report the pancreatic histo- and immunopathology of two children, both HLA-DR 3/4, DQ 2/8 positive and who both died from cerebral oedema within a day of clinical diagnosis of IDDM, were investigated. Patient 1, a 14-month-old girl, had a 4-week history of polydipsia and polyuria. Patient 2, a 3-year-old boy, had 2 days of illness. Both patients had a similarly severe loss of insulin cells but differed markedly as to the extent of lymphocytic islet infiltration (insulitis). Apart from insulitis, marked islet macrophage infiltration was demonstrated in both patients with the HAM-56 monoclonal antibody. Neither patient showed aberrant expression of HLA class II antigens on insulin-immunoreactive cells, but allele-specific HLA-DQ8 expression was evident on endothelial cells. Glutamic acid decarboxylase immunoreactivity was detected in both insulin- and glucagon-immunoreactive cells. It is concluded that the heterogeneity of islet pathology, especially insulitis, may reflect different dynamics and extent rather than different pathomechanisms of immune destruction of islets in IDDM.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Glutamic acid decarboxylase, Insulitis, Islet cell macrophages, Islet destruction, Recent-onset insulin dependent diabetes mellitus
in
Virchows Archiv
volume
425
issue
6
pages
10 pages
publisher
Springer
external identifiers
  • scopus:0028929393
  • pmid:7697219
ISSN
0945-6317
DOI
10.1007/BF00199353
language
English
LU publication?
yes
id
fc721091-13e3-452f-8bf2-55f5e559600f
date added to LUP
2019-09-11 08:55:35
date last changed
2024-06-27 04:44:24
@article{fc721091-13e3-452f-8bf2-55f5e559600f,
  abstract     = {{<p>The mechanisms by which the beta cells of pancreatic islets are destroyed in insulin-dependent diabetes mellitus (IDDM) are poorly understood. In this report the pancreatic histo- and immunopathology of two children, both HLA-DR 3/4, DQ 2/8 positive and who both died from cerebral oedema within a day of clinical diagnosis of IDDM, were investigated. Patient 1, a 14-month-old girl, had a 4-week history of polydipsia and polyuria. Patient 2, a 3-year-old boy, had 2 days of illness. Both patients had a similarly severe loss of insulin cells but differed markedly as to the extent of lymphocytic islet infiltration (insulitis). Apart from insulitis, marked islet macrophage infiltration was demonstrated in both patients with the HAM-56 monoclonal antibody. Neither patient showed aberrant expression of HLA class II antigens on insulin-immunoreactive cells, but allele-specific HLA-DQ8 expression was evident on endothelial cells. Glutamic acid decarboxylase immunoreactivity was detected in both insulin- and glucagon-immunoreactive cells. It is concluded that the heterogeneity of islet pathology, especially insulitis, may reflect different dynamics and extent rather than different pathomechanisms of immune destruction of islets in IDDM.</p>}},
  author       = {{Lernmark, Å and Stenger, D. and Baskin, D. G. and Palmer, J. P. and Li, L. and Klöppel, G. and Vathanaprida, C. and Fält, K. and Landin-Olsson, M. and Gown, A. M. and Petersen, J. S. and Edenvall, H. and Mauseth, R. S.}},
  issn         = {{0945-6317}},
  keywords     = {{Glutamic acid decarboxylase; Insulitis; Islet cell macrophages; Islet destruction; Recent-onset insulin dependent diabetes mellitus}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{6}},
  pages        = {{631--640}},
  publisher    = {{Springer}},
  series       = {{Virchows Archiv}},
  title        = {{Heterogeneity of islet pathology in two infants with recent onset diabetes mellitus}},
  url          = {{http://dx.doi.org/10.1007/BF00199353}},
  doi          = {{10.1007/BF00199353}},
  volume       = {{425}},
  year         = {{1995}},
}