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A prospective analysis of antibodies reacting with pancreatic islet cells in insulin-dependent diabetic children

Lernmark, Å LU ; Hägglöf, B. ; Freedman, Z. ; Irvine, J. ; Ludvigsson, J. LU and Holmgren, G. LU (1981) In Diabetologia 20(4). p.471-474
Abstract

Islet cell cytoplasmic and cell surface antibodies along with other autogenic tissue antibodies were determined prospectively from the day of diagnosis of insulin-dependent diabetes in a group of children and adolescents. Prior to the initiation of insulin therapy 30 out of 33 were antibody-positive, 67% having islet cytoplasmic antibodies and 67% islet cell surface antibodies. Among 74 age- and sex-matched non-diabetic individuals 1% had islet cell cytoplasmic antibodies and 3% had islet cell surface antibodies. A prospective analysis in 17 patients showed a diminishing prevalence of islet cell antibodies with increasing duration of diabetes. Islet cell cytoplasmic or cell surface antibodies were found independently of each other or in... (More)

Islet cell cytoplasmic and cell surface antibodies along with other autogenic tissue antibodies were determined prospectively from the day of diagnosis of insulin-dependent diabetes in a group of children and adolescents. Prior to the initiation of insulin therapy 30 out of 33 were antibody-positive, 67% having islet cytoplasmic antibodies and 67% islet cell surface antibodies. Among 74 age- and sex-matched non-diabetic individuals 1% had islet cell cytoplasmic antibodies and 3% had islet cell surface antibodies. A prospective analysis in 17 patients showed a diminishing prevalence of islet cell antibodies with increasing duration of diabetes. Islet cell cytoplasmic or cell surface antibodies were found independently of each other or in combination and with various patterns of persistence. The results indicate a strong association of islet cell antibodies with the onset of insulin-dependent diabetes in childhood and adolescence.

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author
publishing date
type
Contribution to journal
publication status
published
keywords
autoimmunity, Insulin-dependent diabetes, islet cell antibodies, islet cell surface antobodies
in
Diabetologia
volume
20
issue
4
pages
4 pages
publisher
Springer
external identifiers
  • scopus:0019484907
  • pmid:7016642
ISSN
0012-186X
DOI
10.1007/BF00253410
language
English
LU publication?
no
id
fd058984-28dc-4e9d-bec8-fb145ef08915
date added to LUP
2019-09-16 15:34:40
date last changed
2019-11-25 09:34:26
@article{fd058984-28dc-4e9d-bec8-fb145ef08915,
  abstract     = {<p>Islet cell cytoplasmic and cell surface antibodies along with other autogenic tissue antibodies were determined prospectively from the day of diagnosis of insulin-dependent diabetes in a group of children and adolescents. Prior to the initiation of insulin therapy 30 out of 33 were antibody-positive, 67% having islet cytoplasmic antibodies and 67% islet cell surface antibodies. Among 74 age- and sex-matched non-diabetic individuals 1% had islet cell cytoplasmic antibodies and 3% had islet cell surface antibodies. A prospective analysis in 17 patients showed a diminishing prevalence of islet cell antibodies with increasing duration of diabetes. Islet cell cytoplasmic or cell surface antibodies were found independently of each other or in combination and with various patterns of persistence. The results indicate a strong association of islet cell antibodies with the onset of insulin-dependent diabetes in childhood and adolescence.</p>},
  author       = {Lernmark, Å and Hägglöf, B. and Freedman, Z. and Irvine, J. and Ludvigsson, J. and Holmgren, G.},
  issn         = {0012-186X},
  language     = {eng},
  month        = {01},
  number       = {4},
  pages        = {471--474},
  publisher    = {Springer},
  series       = {Diabetologia},
  title        = {A prospective analysis of antibodies reacting with pancreatic islet cells in insulin-dependent diabetic children},
  url          = {http://dx.doi.org/10.1007/BF00253410},
  doi          = {10.1007/BF00253410},
  volume       = {20},
  year         = {1981},
}