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Increased frequency of retinopathy of prematurity over the last decade and significant regional differences

Holmström, Gerd; Tornqvist, Kristina LU ; Al-Hawasi, Abbas; Nilsson, Åsa; Wallin, Agneta and Hellström, Ann LU (2018) In Acta Ophthalmologica 96(2). p.142-148
Abstract

Purpose: Retinopathy of prematurity (ROP) causes childhood blindness globally in prematurely born infants. Although increased levels of oxygen supply lead to increased survival and reduced frequency of cerebral palsy, increased incidence of ROP is reported. Methods: With the help of a Swedish register for ROP, SWEDROP, national and regional incidences of ROP and frequencies of treatment were evaluated from 2008 to 2015 (n = 5734), as well as before and after targets of provided oxygen changed from 85-89% to 91-95% in 2014. Results: Retinopathy of prematurity (ROP) was found in 31.9% (1829/5734) of all infants with a gestational age (GA) of <31 weeks at birth and 5.7% of the infants (329/5734) had been treated for ROP. Analyses of the... (More)

Purpose: Retinopathy of prematurity (ROP) causes childhood blindness globally in prematurely born infants. Although increased levels of oxygen supply lead to increased survival and reduced frequency of cerebral palsy, increased incidence of ROP is reported. Methods: With the help of a Swedish register for ROP, SWEDROP, national and regional incidences of ROP and frequencies of treatment were evaluated from 2008 to 2015 (n = 5734), as well as before and after targets of provided oxygen changed from 85-89% to 91-95% in 2014. Results: Retinopathy of prematurity (ROP) was found in 31.9% (1829/5734) of all infants with a gestational age (GA) of <31 weeks at birth and 5.7% of the infants (329/5734) had been treated for ROP. Analyses of the national data revealed an increased incidence of ROP during the 8-year study period (p = 0.003), but there was no significant increase in the frequency of treatment. There were significant differences between the seven health regions of Sweden, regarding both incidence of ROP and frequency of treatment (p < 0.001). Comparison of regional data before and after the new oxygen targets revealed a significant increase in treated ROP in one region [OR: 2.24 (CI: 1.11-4.49), p = 0.024] and a borderline increase in one other [OR: 3.08 (CI: 0.99-9.60), p = 0.052]. Conclusion: The Swedish national ROP register revealed an increased incidence of ROP during an 8-year period and significant regional differences regarding the incidence of ROP and frequency of treatment.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Incidence, Oxygen, Retinopathy of prematurity, Treatment
in
Acta Ophthalmologica
volume
96
issue
2
pages
142 - 148
publisher
Wiley-Blackwell
external identifiers
  • scopus:85032185934
ISSN
1755-375X
DOI
10.1111/aos.13549
language
English
LU publication?
yes
id
fd0a0c97-af67-4253-93f7-73118e8415f1
date added to LUP
2017-11-15 14:09:05
date last changed
2018-03-25 04:41:05
@article{fd0a0c97-af67-4253-93f7-73118e8415f1,
  abstract     = {<p>Purpose: Retinopathy of prematurity (ROP) causes childhood blindness globally in prematurely born infants. Although increased levels of oxygen supply lead to increased survival and reduced frequency of cerebral palsy, increased incidence of ROP is reported. Methods: With the help of a Swedish register for ROP, SWEDROP, national and regional incidences of ROP and frequencies of treatment were evaluated from 2008 to 2015 (n = 5734), as well as before and after targets of provided oxygen changed from 85-89% to 91-95% in 2014. Results: Retinopathy of prematurity (ROP) was found in 31.9% (1829/5734) of all infants with a gestational age (GA) of &lt;31 weeks at birth and 5.7% of the infants (329/5734) had been treated for ROP. Analyses of the national data revealed an increased incidence of ROP during the 8-year study period (p = 0.003), but there was no significant increase in the frequency of treatment. There were significant differences between the seven health regions of Sweden, regarding both incidence of ROP and frequency of treatment (p &lt; 0.001). Comparison of regional data before and after the new oxygen targets revealed a significant increase in treated ROP in one region [OR: 2.24 (CI: 1.11-4.49), p = 0.024] and a borderline increase in one other [OR: 3.08 (CI: 0.99-9.60), p = 0.052]. Conclusion: The Swedish national ROP register revealed an increased incidence of ROP during an 8-year period and significant regional differences regarding the incidence of ROP and frequency of treatment.</p>},
  author       = {Holmström, Gerd and Tornqvist, Kristina and Al-Hawasi, Abbas and Nilsson, Åsa and Wallin, Agneta and Hellström, Ann},
  issn         = {1755-375X},
  keyword      = {Incidence,Oxygen,Retinopathy of prematurity,Treatment},
  language     = {eng},
  number       = {2},
  pages        = {142--148},
  publisher    = {Wiley-Blackwell},
  series       = {Acta Ophthalmologica},
  title        = {Increased frequency of retinopathy of prematurity over the last decade and significant regional differences},
  url          = {http://dx.doi.org/10.1111/aos.13549},
  volume       = {96},
  year         = {2018},
}