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Elevated ambulatory systolic-diastolic pressure regression index is genetically determined in hypertensive patients with coronary heart disease

Wirtwein, Marcin; Melander, Olle LU ; Sjőgren, Marketa LU ; Hoffmann, Michal; Narkiewicz, Krzysztof; Gruchala, Marcin and Sobiczewski, Wojciech (2017) In Blood Pressure 26(3). p.174-180
Abstract

Objectives: Ambulatory systolic-diastolic pressure regression index (ASDPRI) as a composite marker of cardiovascular (CV) properties is related to CV complications. However, genetic determinants of ASDPRI are not known. The aim of this study is to report the relationship between certain single nucleotide polymorphisms (SNP) and ASDPRI in hypertensive patients with CAD confirmed by coronary angiography. Methods: A total of 1345 hypertensive subjects with CAD were included. SNPs were selected from genome-wide association studies. SNPs were reported to be associated with coronary artery disease risk. There were significant differences in 24 h and daytime and nighttime ASDPRIs for PHCTR1, LPA and ADAMTS7 polymorphisms. Genetic risk score... (More)

Objectives: Ambulatory systolic-diastolic pressure regression index (ASDPRI) as a composite marker of cardiovascular (CV) properties is related to CV complications. However, genetic determinants of ASDPRI are not known. The aim of this study is to report the relationship between certain single nucleotide polymorphisms (SNP) and ASDPRI in hypertensive patients with CAD confirmed by coronary angiography. Methods: A total of 1345 hypertensive subjects with CAD were included. SNPs were selected from genome-wide association studies. SNPs were reported to be associated with coronary artery disease risk. There were significant differences in 24 h and daytime and nighttime ASDPRIs for PHCTR1, LPA and ADAMTS7 polymorphisms. Genetic risk score (GRS18) was constructed to evaluate additive effect of 18 SNPs for ASDPRI. Results: Analysis of covariance revealed a significant relationship between the PPAB2B (β − 0.85; 95 CI −1.85–−0.16, p < 0.02), WDR12 (β − 1.31; 95 CI −2.19–−0.43, p < 0.01) polymorphisms and nighttime ASDPRI dipping. Analysis of covariance revealed a significant relationship between GRS 18 and 24-h ASDPRI (β 0.34; 95 CI 0.16–0.31, p < 0.01). Conclusions: In conclusion, ADAMTS7 and LPA polymorphisms are related to 24-h ASDPRI but PPAB2B and WDR12 gene polymorphisms are associated with nighttime ASDPRI dipping. A total of 24-h ASDPRI is determined by GRS18.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
coronary artery disease, dipping, DNA polymorphism, hypertension
in
Blood Pressure
volume
26
issue
3
pages
10 pages
publisher
Taylor & Francis
external identifiers
  • scopus:85009760495
  • wos:000395147800007
ISSN
0803-7051
DOI
10.1080/08037051.2016.1273741
language
English
LU publication?
yes
id
fd1acd80-ae13-4b8d-9de4-95bfd73a1351
date added to LUP
2017-02-06 10:37:17
date last changed
2018-01-07 11:48:39
@article{fd1acd80-ae13-4b8d-9de4-95bfd73a1351,
  abstract     = {<p>Objectives: Ambulatory systolic-diastolic pressure regression index (ASDPRI) as a composite marker of cardiovascular (CV) properties is related to CV complications. However, genetic determinants of ASDPRI are not known. The aim of this study is to report the relationship between certain single nucleotide polymorphisms (SNP) and ASDPRI in hypertensive patients with CAD confirmed by coronary angiography. Methods: A total of 1345 hypertensive subjects with CAD were included. SNPs were selected from genome-wide association studies. SNPs were reported to be associated with coronary artery disease risk. There were significant differences in 24 h and daytime and nighttime ASDPRIs for PHCTR1, LPA and ADAMTS7 polymorphisms. Genetic risk score (GRS18) was constructed to evaluate additive effect of 18 SNPs for ASDPRI. Results: Analysis of covariance revealed a significant relationship between the PPAB2B (β − 0.85; 95 CI −1.85–−0.16, p &lt; 0.02), WDR12 (β − 1.31; 95 CI −2.19–−0.43, p &lt; 0.01) polymorphisms and nighttime ASDPRI dipping. Analysis of covariance revealed a significant relationship between GRS 18 and 24-h ASDPRI (β 0.34; 95 CI 0.16–0.31, p &lt; 0.01). Conclusions: In conclusion, ADAMTS7 and LPA polymorphisms are related to 24-h ASDPRI but PPAB2B and WDR12 gene polymorphisms are associated with nighttime ASDPRI dipping. A total of 24-h ASDPRI is determined by GRS18.</p>},
  author       = {Wirtwein, Marcin and Melander, Olle and Sjőgren, Marketa and Hoffmann, Michal and Narkiewicz, Krzysztof and Gruchala, Marcin and Sobiczewski, Wojciech},
  issn         = {0803-7051},
  keyword      = {coronary artery disease,dipping,DNA polymorphism,hypertension},
  language     = {eng},
  month        = {01},
  number       = {3},
  pages        = {174--180},
  publisher    = {Taylor & Francis},
  series       = {Blood Pressure},
  title        = {Elevated ambulatory systolic-diastolic pressure regression index is genetically determined in hypertensive patients with coronary heart disease},
  url          = {http://dx.doi.org/10.1080/08037051.2016.1273741},
  volume       = {26},
  year         = {2017},
}