Formation of macroporous self-assembled hydrogels through cryogelation of Fmoc-Phe-Phe.
(2012) In Journal of Colloid and Interface Science 368(1). p.226-230- Abstract
- In this study, it was found that macroporous hydrogels were formed when self-assembly of fluorenyl-9-methoxycarbonyl (Fmoc)-diphenylalanine (Phe-Phe) peptides was induced using glucono-δ-lactone (GdL) in apparently frozen samples. Formed cryogels exhibited a heterogeneous structure with pore walls of densely packed fibres of assembled dipeptides and pores in the range 10-100μm. Hydrogels formed from the same composition above the freezing point exhibited a homogenous structure without any apparent porosity. The formed gels were characterised using microscopy techniques, CD-spectroscopy and stress sweeps. The cryogels exhibited less mechanical strength than the hydrogels that might be due to the heterogeneous structure of the former. It... (More)
- In this study, it was found that macroporous hydrogels were formed when self-assembly of fluorenyl-9-methoxycarbonyl (Fmoc)-diphenylalanine (Phe-Phe) peptides was induced using glucono-δ-lactone (GdL) in apparently frozen samples. Formed cryogels exhibited a heterogeneous structure with pore walls of densely packed fibres of assembled dipeptides and pores in the range 10-100μm. Hydrogels formed from the same composition above the freezing point exhibited a homogenous structure without any apparent porosity. The formed gels were characterised using microscopy techniques, CD-spectroscopy and stress sweeps. The cryogels exhibited less mechanical strength than the hydrogels that might be due to the heterogeneous structure of the former. It appeared that the self-assembled peptide both in the cryo- and hydrogel maintained the β-sheet structure commonly attributed to these. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2274741
- author
- Berillo, Dmitry LU ; Mattiasson, Bo LU ; Galaev, Igor LU and Kirsebom, Harald LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Colloid and Interface Science
- volume
- 368
- issue
- 1
- pages
- 226 - 230
- publisher
- Elsevier
- external identifiers
-
- wos:000299490500029
- pmid:22129632
- scopus:84855861204
- ISSN
- 1095-7103
- DOI
- 10.1016/j.jcis.2011.11.006
- language
- English
- LU publication?
- yes
- id
- fd33f35e-6736-437b-8abe-0c76766969b8 (old id 2274741)
- date added to LUP
- 2016-04-01 10:24:49
- date last changed
- 2022-01-25 22:58:10
@article{fd33f35e-6736-437b-8abe-0c76766969b8, abstract = {{In this study, it was found that macroporous hydrogels were formed when self-assembly of fluorenyl-9-methoxycarbonyl (Fmoc)-diphenylalanine (Phe-Phe) peptides was induced using glucono-δ-lactone (GdL) in apparently frozen samples. Formed cryogels exhibited a heterogeneous structure with pore walls of densely packed fibres of assembled dipeptides and pores in the range 10-100μm. Hydrogels formed from the same composition above the freezing point exhibited a homogenous structure without any apparent porosity. The formed gels were characterised using microscopy techniques, CD-spectroscopy and stress sweeps. The cryogels exhibited less mechanical strength than the hydrogels that might be due to the heterogeneous structure of the former. It appeared that the self-assembled peptide both in the cryo- and hydrogel maintained the β-sheet structure commonly attributed to these.}}, author = {{Berillo, Dmitry and Mattiasson, Bo and Galaev, Igor and Kirsebom, Harald}}, issn = {{1095-7103}}, language = {{eng}}, number = {{1}}, pages = {{226--230}}, publisher = {{Elsevier}}, series = {{Journal of Colloid and Interface Science}}, title = {{Formation of macroporous self-assembled hydrogels through cryogelation of Fmoc-Phe-Phe.}}, url = {{http://dx.doi.org/10.1016/j.jcis.2011.11.006}}, doi = {{10.1016/j.jcis.2011.11.006}}, volume = {{368}}, year = {{2012}}, }