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Outcome of peripheral T-cell lymphoma in first complete remission : a Danish-Swedish population-based study

Cederleuf, Henrik LU ; Hjort Jakobsen, Lasse; Ellin, Fredrik LU ; de Nully Brown, Peter; Stauffer Larsen, Thomas; Bøgsted, Martin; Relander, Thomas LU ; Jerkeman, Mats LU and El-Galaly, Tarec Christoffer (2017) In Leukemia and Lymphoma 58(12). p.2815-2823
Abstract

In the present study, we investigate the outcome of 109 Danish and 123 Swedish patients with nodal PTCL in first complete remission (CR), and examine the impact of imaging-based follow-up (FU) strategies. The patients were selected by the following criteria: (a) newly diagnosed nodal PTCL from 2007 to 2012, (b) age ≥18 years, and (c) CR after CHOP or CHOEP therapy. FU guidelines in Sweden included symptom assessment, clinical examinations and blood tests at 3–4-month intervals for 2 years. FU strategies in Denmark was similar but included routine imaging, usually every 6 months for 2 years. Patients had fully comparable characteristics. Overall survival (OS) estimates for patients in CR were similar for all patients (p =.6) and in PTCL... (More)

In the present study, we investigate the outcome of 109 Danish and 123 Swedish patients with nodal PTCL in first complete remission (CR), and examine the impact of imaging-based follow-up (FU) strategies. The patients were selected by the following criteria: (a) newly diagnosed nodal PTCL from 2007 to 2012, (b) age ≥18 years, and (c) CR after CHOP or CHOEP therapy. FU guidelines in Sweden included symptom assessment, clinical examinations and blood tests at 3–4-month intervals for 2 years. FU strategies in Denmark was similar but included routine imaging, usually every 6 months for 2 years. Patients had fully comparable characteristics. Overall survival (OS) estimates for patients in CR were similar for all patients (p =.6) and in PTCL subtypes. In multivariate analysis, country of follow-up had no impact on OS. However, despite continuous CR for ≥2 years, the OS of PTCL remained inferior to a matched general population.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Peripheral T-cell lymphoma, population based, routine imaging
in
Leukemia and Lymphoma
volume
58
issue
12
pages
9 pages
publisher
Taylor & Francis
external identifiers
  • scopus:85015649605
  • wos:000406290000006
ISSN
1042-8194
DOI
10.1080/10428194.2017.1300888
language
English
LU publication?
yes
id
fd41a875-9bbf-4697-b874-09c5a66b89e3
date added to LUP
2017-11-22 07:56:57
date last changed
2018-05-06 04:38:20
@article{fd41a875-9bbf-4697-b874-09c5a66b89e3,
  abstract     = {<p>In the present study, we investigate the outcome of 109 Danish and 123 Swedish patients with nodal PTCL in first complete remission (CR), and examine the impact of imaging-based follow-up (FU) strategies. The patients were selected by the following criteria: (a) newly diagnosed nodal PTCL from 2007 to 2012, (b) age ≥18 years, and (c) CR after CHOP or CHOEP therapy. FU guidelines in Sweden included symptom assessment, clinical examinations and blood tests at 3–4-month intervals for 2 years. FU strategies in Denmark was similar but included routine imaging, usually every 6 months for 2 years. Patients had fully comparable characteristics. Overall survival (OS) estimates for patients in CR were similar for all patients (p =.6) and in PTCL subtypes. In multivariate analysis, country of follow-up had no impact on OS. However, despite continuous CR for ≥2 years, the OS of PTCL remained inferior to a matched general population.</p>},
  author       = {Cederleuf, Henrik and Hjort Jakobsen, Lasse and Ellin, Fredrik and de Nully Brown, Peter and Stauffer Larsen, Thomas and Bøgsted, Martin and Relander, Thomas and Jerkeman, Mats and El-Galaly, Tarec Christoffer},
  issn         = {1042-8194},
  keyword      = {Peripheral T-cell lymphoma,population based,routine imaging},
  language     = {eng},
  month        = {12},
  number       = {12},
  pages        = {2815--2823},
  publisher    = {Taylor & Francis},
  series       = {Leukemia and Lymphoma},
  title        = {Outcome of peripheral T-cell lymphoma in first complete remission : a Danish-Swedish population-based study},
  url          = {http://dx.doi.org/10.1080/10428194.2017.1300888},
  volume       = {58},
  year         = {2017},
}