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Full-field electroretinography in age-related macular degeneration : an overall retinal response

Forshaw, Thomas Richard Johansen ; Kjær, Troels Wesenberg ; Andréasson, Sten LU and Sørensen, Torben Lykke (2020) In Acta Ophthalmologica
Abstract

Purpose: Age-related macular degeneration (AMD) is generally considered a disease of the macula. However, recent studies show peripheral retinal lesions are prevalent in patients with AMD, indicative of a disease process that is more widespread. Full-field electroretinography (ffERG) measures an electrical response, not only from the macula, but from the entire retina. We wanted to study the ffERG response in eyes with AMD. Methods: We performed full-field electroretinography (RETI-port/scan 21, Roland, Berlin) in 13 patients with early AMD, 25 patients with late AMD and 24 individuals without vitreoretinal disease as a control group. Dawson–Trick–Litzkow fibre electrodes were used. Statistical analysis was performed and a p-value... (More)

Purpose: Age-related macular degeneration (AMD) is generally considered a disease of the macula. However, recent studies show peripheral retinal lesions are prevalent in patients with AMD, indicative of a disease process that is more widespread. Full-field electroretinography (ffERG) measures an electrical response, not only from the macula, but from the entire retina. We wanted to study the ffERG response in eyes with AMD. Methods: We performed full-field electroretinography (RETI-port/scan 21, Roland, Berlin) in 13 patients with early AMD, 25 patients with late AMD and 24 individuals without vitreoretinal disease as a control group. Dawson–Trick–Litzkow fibre electrodes were used. Statistical analysis was performed and a p-value <0.05 was considered significant. Results: After adjusting for multiple comparisons, both the light-adapted 3.0 a-wave implicit time (p < 0.001) and 30-Hertz flicker peak time (p = 0.012) showed significant difference between patients with late AMD and individuals without vitreoretinal disease. There was a significant difference in the light-adapted 3.0 a-wave implicit time (p = 0.011) between patients with early AMD and the control group, but the difference in 30 Hz flicker peak time was not significant (p = 0.256). Conclusion: The difference in cone function measured by light-adapted 3.0 a-wave implicit time and 30-Hertz flicker peak time in early and late AMD when compared to healthy controls suggests a more diminished overall response when AMD has reached later stages.

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author
; ; and
publishing date
type
Contribution to journal
publication status
epub
subject
keywords
age-related macular degeneration, full-field electroretinography, functional testing, peripheral retina
in
Acta Ophthalmologica
publisher
Wiley-Blackwell
external identifiers
  • pmid:32833310
  • scopus:85089733787
ISSN
1755-375X
DOI
10.1111/aos.14571
language
English
LU publication?
no
id
fd7bbb1c-a496-4a61-be8e-05526e5a3dc3
date added to LUP
2020-09-09 16:55:08
date last changed
2020-09-10 03:00:03
@article{fd7bbb1c-a496-4a61-be8e-05526e5a3dc3,
  abstract     = {<p>Purpose: Age-related macular degeneration (AMD) is generally considered a disease of the macula. However, recent studies show peripheral retinal lesions are prevalent in patients with AMD, indicative of a disease process that is more widespread. Full-field electroretinography (ffERG) measures an electrical response, not only from the macula, but from the entire retina. We wanted to study the ffERG response in eyes with AMD. Methods: We performed full-field electroretinography (RETI-port/scan 21, Roland, Berlin) in 13 patients with early AMD, 25 patients with late AMD and 24 individuals without vitreoretinal disease as a control group. Dawson–Trick–Litzkow fibre electrodes were used. Statistical analysis was performed and a p-value &lt;0.05 was considered significant. Results: After adjusting for multiple comparisons, both the light-adapted 3.0 a-wave implicit time (p &lt; 0.001) and 30-Hertz flicker peak time (p = 0.012) showed significant difference between patients with late AMD and individuals without vitreoretinal disease. There was a significant difference in the light-adapted 3.0 a-wave implicit time (p = 0.011) between patients with early AMD and the control group, but the difference in 30 Hz flicker peak time was not significant (p = 0.256). Conclusion: The difference in cone function measured by light-adapted 3.0 a-wave implicit time and 30-Hertz flicker peak time in early and late AMD when compared to healthy controls suggests a more diminished overall response when AMD has reached later stages.</p>},
  author       = {Forshaw, Thomas Richard Johansen and Kjær, Troels Wesenberg and Andréasson, Sten and Sørensen, Torben Lykke},
  issn         = {1755-375X},
  language     = {eng},
  month        = {01},
  publisher    = {Wiley-Blackwell},
  series       = {Acta Ophthalmologica},
  title        = {Full-field electroretinography in age-related macular degeneration : an overall retinal response},
  url          = {http://dx.doi.org/10.1111/aos.14571},
  doi          = {10.1111/aos.14571},
  year         = {2020},
}