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Expression of ETA and ETB receptor mRNA in human cerebral arteries

Hansen-Schwartz, J ; Szok, D and Edvinsson, Lars LU (2002) In British Journal of Neurosurgery 16(2). p.149-153
Abstract
The vascular effects of endothelins (ET) are in mammals mediated via two receptor subtypes, endothelin A (ETA, mainly constrictive) and endothelin B (ETB, mainly dilating) receptors. We have examined the presence of ETA and ETB receptor mRNA using the reverse transcription polymerase chain reaction (RT-PCR) in both normal human cerebral arteries and cerebral arteries from patients with cerebrovascular disease. Two vessel preparations were studied: macroscopic arteries and microvessels, the latter obtained through a sensitive separation method. In endothelial cells both ETA and ETB receptor mRNA was detected. In almost all samples from normal cerebral arteries only ETA receptor mRNA was detected, whereas in vessel samples from patients with... (More)
The vascular effects of endothelins (ET) are in mammals mediated via two receptor subtypes, endothelin A (ETA, mainly constrictive) and endothelin B (ETB, mainly dilating) receptors. We have examined the presence of ETA and ETB receptor mRNA using the reverse transcription polymerase chain reaction (RT-PCR) in both normal human cerebral arteries and cerebral arteries from patients with cerebrovascular disease. Two vessel preparations were studied: macroscopic arteries and microvessels, the latter obtained through a sensitive separation method. In endothelial cells both ETA and ETB receptor mRNA was detected. In almost all samples from normal cerebral arteries only ETA receptor mRNA was detected, whereas in vessel samples from patients with cerebrovascular disease as well as cerebral neoplasms, additional ETB receptor mRNA was detected significantly more frequently. The pathophysiological significance of this difference is at present speculative, but does point to a vascular involvement of this receptor in cerebrovascular disease. (Less)
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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
vascular smooth muscle cells, human, endothelium, cerebral arteries, endothelin receptors, mRNA
in
British Journal of Neurosurgery
volume
16
issue
2
pages
149 - 153
publisher
Taylor & Francis
external identifiers
  • pmid:12046734
  • wos:000175337400012
  • scopus:0036112350
ISSN
0268-8697
DOI
10.1080/02688690220131750
language
English
LU publication?
yes
id
fd906d93-61ff-4668-8d9d-29443f7aadd0 (old id 338685)
date added to LUP
2016-04-01 12:18:06
date last changed
2024-10-09 05:13:27
@article{fd906d93-61ff-4668-8d9d-29443f7aadd0,
  abstract     = {{The vascular effects of endothelins (ET) are in mammals mediated via two receptor subtypes, endothelin A (ETA, mainly constrictive) and endothelin B (ETB, mainly dilating) receptors. We have examined the presence of ETA and ETB receptor mRNA using the reverse transcription polymerase chain reaction (RT-PCR) in both normal human cerebral arteries and cerebral arteries from patients with cerebrovascular disease. Two vessel preparations were studied: macroscopic arteries and microvessels, the latter obtained through a sensitive separation method. In endothelial cells both ETA and ETB receptor mRNA was detected. In almost all samples from normal cerebral arteries only ETA receptor mRNA was detected, whereas in vessel samples from patients with cerebrovascular disease as well as cerebral neoplasms, additional ETB receptor mRNA was detected significantly more frequently. The pathophysiological significance of this difference is at present speculative, but does point to a vascular involvement of this receptor in cerebrovascular disease.}},
  author       = {{Hansen-Schwartz, J and Szok, D and Edvinsson, Lars}},
  issn         = {{0268-8697}},
  keywords     = {{vascular smooth muscle cells; human; endothelium; cerebral arteries; endothelin receptors; mRNA}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{149--153}},
  publisher    = {{Taylor & Francis}},
  series       = {{British Journal of Neurosurgery}},
  title        = {{Expression of ETA and ETB receptor mRNA in human cerebral arteries}},
  url          = {{http://dx.doi.org/10.1080/02688690220131750}},
  doi          = {{10.1080/02688690220131750}},
  volume       = {{16}},
  year         = {{2002}},
}