In vivo and in vitro studies of immunoglobulin gene somatic hypermutation
Sale, J. E. ; Bemark, M. LU
; Williams, Gareth
; Jolly, C. J.
; Ehrenstein, M. R.
; Rada, C.
; Milstein, C.
and Neuberger, M. S.
(2001)
In Philosophical Transactions of the Royal Society B: Biological Sciences
355(1405).
p.21-28
- Abstract
Following antigen encounter, two distinct processes modify immunoglobulin genes. The variable region is diversified by somatic hypermutation while the constant region may be changed by class-switch recombination. Although both genetic events can occur concurrently within germinal centre B cells, there are examples of each occurring independently of the other. Here we compare the contributions of classs-witch recombination and somatic hypermutation to the diversification of the serum immunoglobulin repertoire and review evidence that suggests that, despite clear differences, the two processes may share some aspects of their mechanism in common.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/fda14092-2857-4544-baa5-3e467ccf6b9c
- author
- Sale, J. E.
; Bemark, M.
LU
; Williams, Gareth
; Jolly, C. J.
; Ehrenstein, M. R.
; Rada, C.
; Milstein, C.
and Neuberger, M. S.
- publishing date
- 2001-01-29
- type
- Contribution to journal
- publication status
- published
- keywords
- Class-switch recombination, DNA-dependent protein kinase, Immunoglobulin, Somatic hypermutation, Terminal deoxynucleotidyl transferase, Translocation
- in
- Philosophical Transactions of the Royal Society B: Biological Sciences
- volume
- 355
- issue
- 1405
- pages
- 21 - 28
- publisher
- Royal Society Publishing
- external identifiers
-
- pmid:11205326
- scopus:0035966786
- ISSN
- 0962-8436
- language
- English
- LU publication?
- no
- id
- fda14092-2857-4544-baa5-3e467ccf6b9c
- date added to LUP
- 2023-11-28 10:14:03
- date last changed
- 2024-01-10 17:59:59
@article{fda14092-2857-4544-baa5-3e467ccf6b9c,
abstract = {{<p>Following antigen encounter, two distinct processes modify immunoglobulin genes. The variable region is diversified by somatic hypermutation while the constant region may be changed by class-switch recombination. Although both genetic events can occur concurrently within germinal centre B cells, there are examples of each occurring independently of the other. Here we compare the contributions of classs-witch recombination and somatic hypermutation to the diversification of the serum immunoglobulin repertoire and review evidence that suggests that, despite clear differences, the two processes may share some aspects of their mechanism in common.</p>}},
author = {{Sale, J. E. and Bemark, M. and Williams, Gareth and Jolly, C. J. and Ehrenstein, M. R. and Rada, C. and Milstein, C. and Neuberger, M. S.}},
issn = {{0962-8436}},
keywords = {{Class-switch recombination; DNA-dependent protein kinase; Immunoglobulin; Somatic hypermutation; Terminal deoxynucleotidyl transferase; Translocation}},
language = {{eng}},
month = {{01}},
number = {{1405}},
pages = {{21--28}},
publisher = {{Royal Society Publishing}},
series = {{Philosophical Transactions of the Royal Society B: Biological Sciences}},
title = {{In vivo and in vitro studies of immunoglobulin gene somatic hypermutation}},
volume = {{355}},
year = {{2001}},
}