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Recombinant Technology in the Development of Materials and Systems for Soft-Tissue Repair

Girotti, Alessandra ; Orbanic, Doriana LU ; Ibáñez-Fonseca, Arturo LU orcid ; Gonzalez-Obeso, Constancio and Rodríguez-Cabello, José Carlos (2015) In Advanced healthcare materials 4(16). p.55-2423
Abstract

The field of biomedicine is constantly investing significant research efforts in order to gain a more in-depth understanding of the mechanisms that govern the function of body compartments and to develop creative solutions for the repair and regeneration of damaged tissues. The main overall goal is to develop relatively simple systems that are able to mimic naturally occurring constructs and can therefore be used in regenerative medicine. Recombinant technology, which is widely used to obtain new tailored synthetic genes that express polymeric protein-based structures, now offers a broad range of advantages for that purpose by permitting the tuning of biological and mechanical properties depending on the intended application while... (More)

The field of biomedicine is constantly investing significant research efforts in order to gain a more in-depth understanding of the mechanisms that govern the function of body compartments and to develop creative solutions for the repair and regeneration of damaged tissues. The main overall goal is to develop relatively simple systems that are able to mimic naturally occurring constructs and can therefore be used in regenerative medicine. Recombinant technology, which is widely used to obtain new tailored synthetic genes that express polymeric protein-based structures, now offers a broad range of advantages for that purpose by permitting the tuning of biological and mechanical properties depending on the intended application while simultaneously ensuring adequate biocompatibility and biodegradability of the scaffold formed by the polymers. This Progress Report is focused on recombinant protein-based materials that resemble naturally occurring proteins of interest for use in soft tissue repair. An overview of recombinant biomaterials derived from elastin, silk, collagen and resilin is given, along with a description of their characteristics and suggested applications. Current endeavors in this field are continuously providing more-improved materials in comparison with conventional ones. As such, a great effort is being made to put these materials through clinical trials in order to favor their future use.

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Please use this url to cite or link to this publication:
author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
keywords
Amino Acid Sequence, Animals, Biocompatible Materials/pharmacology, Humans, Molecular Sequence Data, Protein Engineering/methods, Recombinant Proteins/chemistry, Tissue Engineering/methods, Wound Healing/drug effects
in
Advanced healthcare materials
volume
4
issue
16
pages
55 - 2423
publisher
John Wiley & Sons Inc.
external identifiers
  • pmid:26172311
  • scopus:84954349299
ISSN
2192-2659
DOI
10.1002/adhm.201500152
language
English
LU publication?
yes
additional info
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
id
fda406a7-be89-4771-9118-8cc37ed06cfb
date added to LUP
2025-09-14 19:40:57
date last changed
2025-09-16 03:30:44
@article{fda406a7-be89-4771-9118-8cc37ed06cfb,
  abstract     = {{<p>The field of biomedicine is constantly investing significant research efforts in order to gain a more in-depth understanding of the mechanisms that govern the function of body compartments and to develop creative solutions for the repair and regeneration of damaged tissues. The main overall goal is to develop relatively simple systems that are able to mimic naturally occurring constructs and can therefore be used in regenerative medicine. Recombinant technology, which is widely used to obtain new tailored synthetic genes that express polymeric protein-based structures, now offers a broad range of advantages for that purpose by permitting the tuning of biological and mechanical properties depending on the intended application while simultaneously ensuring adequate biocompatibility and biodegradability of the scaffold formed by the polymers. This Progress Report is focused on recombinant protein-based materials that resemble naturally occurring proteins of interest for use in soft tissue repair. An overview of recombinant biomaterials derived from elastin, silk, collagen and resilin is given, along with a description of their characteristics and suggested applications. Current endeavors in this field are continuously providing more-improved materials in comparison with conventional ones. As such, a great effort is being made to put these materials through clinical trials in order to favor their future use.</p>}},
  author       = {{Girotti, Alessandra and Orbanic, Doriana and Ibáñez-Fonseca, Arturo and Gonzalez-Obeso, Constancio and Rodríguez-Cabello, José Carlos}},
  issn         = {{2192-2659}},
  keywords     = {{Amino Acid Sequence; Animals; Biocompatible Materials/pharmacology; Humans; Molecular Sequence Data; Protein Engineering/methods; Recombinant Proteins/chemistry; Tissue Engineering/methods; Wound Healing/drug effects}},
  language     = {{eng}},
  month        = {{11}},
  number       = {{16}},
  pages        = {{55--2423}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Advanced healthcare materials}},
  title        = {{Recombinant Technology in the Development of Materials and Systems for Soft-Tissue Repair}},
  url          = {{http://dx.doi.org/10.1002/adhm.201500152}},
  doi          = {{10.1002/adhm.201500152}},
  volume       = {{4}},
  year         = {{2015}},
}