In vitro and in vivo aspects of quantifying intrapulmonary deposition of a dry powder radioaerosol.
(2002) In International Journal of Pharmaceutics 232(1-2). p.149-156- Abstract
- Pulmonary delivery of pharmaceutical aerosols can be quantified using gamma scintigraphy. Technetium-99m, the most commonly used radionuclide in scintigraphic studies, cannot be incorporated into the drug molecule and, therefore, may be distributed differently from the drug itself, particularly if the drug is presented as a solid in a liquid suspension or as a dry powder formulation. This study demonstrated the importance of using conditions relevant to the in vivo situation in the in vitro characterisation of a dry powder aerosol of 99mTc-labelled lactose. The influence of inspiratory flow on the distribution of aerosol within the lungs was investigated in eight healthy subjects who inhaled the 99mTc-labelled lactose at four flows... (More)
- Pulmonary delivery of pharmaceutical aerosols can be quantified using gamma scintigraphy. Technetium-99m, the most commonly used radionuclide in scintigraphic studies, cannot be incorporated into the drug molecule and, therefore, may be distributed differently from the drug itself, particularly if the drug is presented as a solid in a liquid suspension or as a dry powder formulation. This study demonstrated the importance of using conditions relevant to the in vivo situation in the in vitro characterisation of a dry powder aerosol of 99mTc-labelled lactose. The influence of inspiratory flow on the distribution of aerosol within the lungs was investigated in eight healthy subjects who inhaled the 99mTc-labelled lactose at four flows (30,40,60 and 80 l/min). No differences in penetration index (PI) or count density distribution of radioactivity were seen, indicating that regional distribution of aerosol in healthy airways was insensitive to differences in the inspiratory effort exerted by the subject while inhaling the experimental dry powder radioaerosol. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/106679
- author
- Bondesson, Eva LU ; Asking, Lars ; Borgström, Lars ; Nilsson, Lars-Erik ; Trofast, Eva and Wollmer, Per LU
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Cross-Over Studies, Human, Lactose : administration & dosage : pharmacokinetics, Lung : metabolism : radionuclide imaging, Male, Tissue Distribution, Powders, Technetium, Administration Inhalation, Adult, Analysis of Variance
- in
- International Journal of Pharmaceutics
- volume
- 232
- issue
- 1-2
- pages
- 149 - 156
- publisher
- Elsevier
- external identifiers
-
- pmid:11790498
- wos:000173676400014
- scopus:0037203699
- ISSN
- 1873-3476
- DOI
- 10.1016/S0378-5173(01)00898-5
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Clinical Physiology (013242300), Clinical Physiology and Nuclear Medicine Unit (013242320)
- id
- fdd60325-5519-4672-ac7d-09b9130fdf30 (old id 106679)
- alternative location
- http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11790498&dopt=Abstract
- date added to LUP
- 2016-04-01 12:23:03
- date last changed
- 2023-09-02 05:46:49
@article{fdd60325-5519-4672-ac7d-09b9130fdf30,
abstract = {{Pulmonary delivery of pharmaceutical aerosols can be quantified using gamma scintigraphy. Technetium-99m, the most commonly used radionuclide in scintigraphic studies, cannot be incorporated into the drug molecule and, therefore, may be distributed differently from the drug itself, particularly if the drug is presented as a solid in a liquid suspension or as a dry powder formulation. This study demonstrated the importance of using conditions relevant to the in vivo situation in the in vitro characterisation of a dry powder aerosol of 99mTc-labelled lactose. The influence of inspiratory flow on the distribution of aerosol within the lungs was investigated in eight healthy subjects who inhaled the 99mTc-labelled lactose at four flows (30,40,60 and 80 l/min). No differences in penetration index (PI) or count density distribution of radioactivity were seen, indicating that regional distribution of aerosol in healthy airways was insensitive to differences in the inspiratory effort exerted by the subject while inhaling the experimental dry powder radioaerosol.}},
author = {{Bondesson, Eva and Asking, Lars and Borgström, Lars and Nilsson, Lars-Erik and Trofast, Eva and Wollmer, Per}},
issn = {{1873-3476}},
keywords = {{Cross-Over Studies; Human; Lactose : administration & dosage : pharmacokinetics; Lung : metabolism : radionuclide imaging; Male; Tissue Distribution; Powders; Technetium; Administration Inhalation; Adult; Analysis of Variance}},
language = {{eng}},
number = {{1-2}},
pages = {{149--156}},
publisher = {{Elsevier}},
series = {{International Journal of Pharmaceutics}},
title = {{In vitro and in vivo aspects of quantifying intrapulmonary deposition of a dry powder radioaerosol.}},
url = {{http://dx.doi.org/10.1016/S0378-5173(01)00898-5}},
doi = {{10.1016/S0378-5173(01)00898-5}},
volume = {{232}},
year = {{2002}},
}